Objective To explore the value of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)combined with diffusion weighted imaging(DWI)in differential diagnosis of benign and malignant prostate lesions in the peripheral zone.Methods A total of 80 patients with prostate lesions in the peripheral zone were selected.With biopsy results as the gold standard,the patients were divided into benign prostate lesion group and malignant prostate lesion group.The value of DCE-MRI combined with DWI in differential diagnosis of benign and malignant prostate lesions in the peripheral zone was analyzed.Results Prostate-specific antigen(PSA)level in the malignant prostate lesion group was significantly higher than that in the benign prostate lesion group(P＜0.05).The Ktrans,Kep and Ve in the malignant prostate lesion group were significantly higher than those in the benign prostate lesion group(P＜0.05),and the apparent diffusion coefficient(ADC)value was significantly lower than that in the benign prostate lesion group(P＜0.05).According to the results of multivariate logistic regression analysis,the evaluation model was established.Receiver oper-ating characteristic(ROC)curve analysis indicated that the area under the curve(AUC)for distinguishing benign and malignant pros-tate lesions in the peripheral zone was 0.905,the sensitivity and specificity were 0.735 and 0.950.Pearson correlation analysis showed that the Ktrans,Kep and Ve were positively correlated with PSA level in the malignant prostate lesion group,while the ADC value was negatively correlated with PSA level(P＜0.05).Conclusion The quantitative parameters(Ktrans,Kep and Ve)of DCE-MRI and ADC value of DWI are independent influencing factors of malignant prostate lesions in the peripheral zone.The evaluation model construc-ted based on these factors has high value in the differential diagnosis of benign and malignant prostate lesions in the peripheral zone.

Objective To explore the value of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)combined with diffusion weighted imaging(DWI)in differential diagnosis of benign and malignant prostate lesions in the peripheral zone.Methods A total of 80 patients with prostate lesions in the peripheral zone were selected.With biopsy results as the gold standard,the patients were divided into benign prostate lesion group and malignant prostate lesion group.The value of DCE-MRI combined with DWI in differential diagnosis of benign and malignant prostate lesions in the peripheral zone was analyzed.Results Prostate-specific antigen(PSA)level in the malignant prostate lesion group was significantly higher than that in the benign prostate lesion group(P＜0.05).The Ktrans,Kep and Ve in the malignant prostate lesion group were significantly higher than those in the benign prostate lesion group(P＜0.05),and the apparent diffusion coefficient(ADC)value was significantly lower than that in the benign prostate lesion group(P＜0.05).According to the results of multivariate logistic regression analysis,the evaluation model was established.Receiver oper-ating characteristic(ROC)curve analysis indicated that the area under the curve(AUC)for distinguishing benign and malignant pros-tate lesions in the peripheral zone was 0.905,the sensitivity and specificity were 0.735 and 0.950.Pearson correlation analysis showed that the Ktrans,Kep and Ve were positively correlated with PSA level in the malignant prostate lesion group,while the ADC value was negatively correlated with PSA level(P＜0.05).Conclusion The quantitative parameters(Ktrans,Kep and Ve)of DCE-MRI and ADC value of DWI are independent influencing factors of malignant prostate lesions in the peripheral zone.The evaluation model construc-ted based on these factors has high value in the differential diagnosis of benign and malignant prostate lesions in the peripheral zone.

Trauma has the characteristics of complex disease, high disability rate and fatality rate, which adds difficulty to treatment. Due to the limitation of medical conditions and untimely allocation of resources, the current trauma treatment modes still have shortcomings such as low first aid efficiency and irregular application, and hence the treatment is facing enormous challenges. In the process of trauma treatment, a large amount of dynamic data that are valuable for disease diagnosis and treatment will be generated. Big data and artificial intelligence technology is an algorithm that can reasonably predict or estimate the given data based on large-scale data collection, and has been applied to trauma treatment modes. The efficient and accurate statistical analysis of big data and innovative medical technology directions such as machine learning, planning and decision-making not only improve the efficiency and safety of trauma treatment, but also reduce the workload of clinicians, making up for the shortcomings of traditional trauma treatment modes. The authors mainly review the application of big data and artificial intelligence technology in pre-hospital first aid and in-hospital diagnosis and treatment for trauma patients, in order to provide a reference for trauma treatment.

Endogenously eliminating the hematoma is a favorable strategy in addressing intracerebral hemorrhage (ICH). This study sought to determine the role of retinoid X receptor-α (RXR-α) in the context of hematoma absorption after ICH. Our results showed that pharmacologically activating RXR-α with bexarotene significantly accelerated hematoma clearance and alleviated neurological dysfunction after ICH. RXR-α was expressed in microglia/macrophages, neurons, and astrocytes. Mechanistically, bexarotene promoted the nuclear translocation of RXR-α and PPAR-γ, as well as reducing neuroinflammation by modulating microglia/macrophage reprograming from the M1 into the M2 phenotype. Furthermore, all the beneficial effects of RXR-α in ICH were reversed by the PPAR-γ inhibitor GW9662. In conclusion, the pharmacological activation of RXR-α confers robust neuroprotection against ICH by accelerating hematoma clearance and repolarizing microglia/macrophages towards the M2 phenotype through PPAR-γ-related mechanisms. Our data support the notion that RXR-α might be a promising therapeutic target for ICH.
Anilides/pharmacology* ; Cerebral Hemorrhage/drug therapy* ; Hematoma/drug therapy* ; Humans ; Macrophages ; Microglia ; Neuroprotection ; PPAR gamma ; Retinoid X Receptor alpha

Endogenously eliminating the hematoma is a favorable strategy in addressing intracerebral hemorrhage (ICH). This study sought to determine the role of retinoid X receptor-α (RXR-α) in the context of hematoma absorption after ICH. Our results showed that pharmacologically activating RXR-α with bexarotene significantly accelerated hematoma clearance and alleviated neurological dysfunction after ICH. RXR-α was expressed in microglia/macrophages, neurons, and astrocytes. Mechanistically, bexarotene promoted the nuclear translocation of RXR-α and PPAR-γ, as well as reducing neuroinflammation by modulating microglia/macrophage reprograming from the M1 into the M2 phenotype. Furthermore, all the beneficial effects of RXR-α in ICH were reversed by the PPAR-γ inhibitor GW9662. In conclusion, the pharmacological activation of RXR-α confers robust neuroprotection against ICH by accelerating hematoma clearance and repolarizing microglia/macrophages towards the M2 phenotype through PPAR-γ-related mechanisms. Our data support the notion that RXR-α might be a promising therapeutic target for ICH.

OBJECTIVETo review the influencing factors of the early complication after carotid endarterectomy (CEA).

METHODSRetrospective analysis of clinical data of 509 cases received CEA in Xuan Wu Hospital of Capital Medical University, Liaocheng People's Hospital and Dalian Central Hospital from January 2001 to December 2011. There are 422 male patients and 72 female patients among the 494 patients, 15 patients underwent CEA by stages. The patients were between 35-84 years old,and the mean age was (64 ± 9) years. The complications within 30 days after CEA were analyzed, and find the risk factors for the major adverse events. Chi-square analysis was performed to analyze the correlation between the each variable of the basic characteristics of population, clinical features and intraoperative data and early adverse events after CEA. Logistic regression analysis was used to assess the relationship between a variety of factors and the postoperative complications within 30 days.

RESULTSTechnical complete rate of 98.6%, 7 cases of near-total occlusion patients could not been recanalized. Major complications in 30 days after CEA occurred in 20 cases (3.9%), including 6 cases of deaths (1.2%), 9 cases of cerebral infarction (1.8%) and 5 cases of cerebral hemorrhage (1.0%). Secondary complications occurred in 120 cases (23.6%). Univariate analysis showed modified Rankin scale (mRS) ≥ 3 on the incidence of early postoperative complication had significantly difference (χ² =20.517, P < 0.01), multivariate logistic regression analysis revealed that smoking (OR=2.667, 95% CI: 1.048-6.791, P=0.040) and mRS ≥ 3 (OR=8.690, 95% CI: 3.279-23.031, P=0.000) were the significant predictors of 30 days of the end event.

CONCLUSIONThe complications after CEA are uncommon, the security is proved. Smoking and mRS ≥ 3 can increase the risk of CEA.

Adult ; Aged ; Aged, 80 and over ; Cerebral Hemorrhage ; complications ; Cerebral Infarction ; complications ; Endarterectomy, Carotid ; adverse effects ; Female ; Humans ; Incidence ; Male ; Middle Aged ; Postoperative Complications ; Retrospective Studies ; Risk Factors ; Smoking ; Time Factors ; Treatment Outcome

OBJECTIVETo study the gene mutation and streptomycin, isoniazid or rifampicin resistance of Mycobacterium isolated from silico-tuberculosis patient's sputum so as to find a more effective therapy for this disease.

METHODSMycobacteria tuberculosis were separated from 96 coal worker with silico-tuberculosis firstly. Then rpsL, KatG and rpoB fragments of genome were copied with PCR and compared their SSCP profiles with standard strains.

RESULTS67 strains of streptomycin, isoniazid or rifampicin resistant Mycobacteria tuberculosis were found in routine drug resistance test, with the percentages of 80.5% (54/67), 58.2% (39/67) respectively. PCR-SSCP showed that out of 67 drug-resistant strains, 66(98.5%) of rpsL, 47(70.1%) of rpoB and 42(62.7%) of KatG appeared abnormal.

CONCLUSIONMost of the resistant strains appeared gene mutation. The mution rates were higher than the results from routine drug resistance test.

Coal ; Drug Resistance, Bacterial ; Humans ; Mutation ; Mycobacterium tuberculosis ; drug effects ; genetics ; Polymerase Chain Reaction ; Polymorphism, Single-Stranded Conformational ; Silicotuberculosis ; microbiology ; Sputum ; microbiology