Party affairs cadres in public hospitals play a significant role in promoting high-quality development within hospitals.Their competence and quality directly influence the level of Party construction work in public hospitals and affect the comprehensive development of hospitals.They also serve as an important window for the Party to connect with and serve the peo-ple.Based on competency theory,this study selects Party affairs cadres in public hospitals as the research subjects.Through lit-erature review and interviews,competency elements are summarized,and a competency model for Party affairs cadres in public hospitals is constructed.From four dimensions-innovating selection and training mechanisms,developing career planning and mentorship systems,strengthening performance management and incentive mechanisms,and fostering a learning-oriented organi-zational atmosphere-this study proposes innovative strategies for building a team of Party affairs cadres in public hospitals.

Party affairs cadres in public hospitals play a significant role in promoting high-quality development within hospitals.Their competence and quality directly influence the level of Party construction work in public hospitals and affect the comprehensive development of hospitals.They also serve as an important window for the Party to connect with and serve the peo-ple.Based on competency theory,this study selects Party affairs cadres in public hospitals as the research subjects.Through lit-erature review and interviews,competency elements are summarized,and a competency model for Party affairs cadres in public hospitals is constructed.From four dimensions-innovating selection and training mechanisms,developing career planning and mentorship systems,strengthening performance management and incentive mechanisms,and fostering a learning-oriented organi-zational atmosphere-this study proposes innovative strategies for building a team of Party affairs cadres in public hospitals.

Objective To explore the computed tomography angiography(CTA)and clinical features of Takayasu's arteritis(TA)with peripheral artery involvement.Methods In this retrospective study,CTA scan was performed in a total of 184 TA patients.TA patients were divided into two groups:60 patients within peripheral artery involvement(peripheral artery involvement group)and 124 patients without peripheral artery involvement(peripheral artery non-involvement group).The difference in comparison of clini-cal data and CTA findings were analyzed.Results A total of 194 peripheral arteries were involved in 60 patients.The most suscep-tible peripheral artery were axillary artery(52,26.8％),middle cerebral artery(26,13.4％)and femoral artery(22,11.3％).In the peripheral artery involvement group,the most common CTA manifestation was luminal stenosis(141,72.7％).The lumen dilata-tion,lumen stenosis with dilatation and wall calcification were not easy to be observed.The age and duration of disease in peripheral artery involvement group were significantly greater than those in peripheral artery non-involvement group(P＜0.05).The proportion of the peripheral artery involvement group in the active phase was significantly lower than that of the peripheral artery non-involvement group(P＜0.05).The incidence of pain in the limbs in peripheral artery involvement group was significantly higher than that in peripheral artery non-involvement group(P＜0.05).The utilization rate of tocilizumab in the peripheral artery involvement group was significantly higher than that in the peripheral artery non-involvement group(P＜0.05).Conclusion TA involving peripheral arteries is more common in patients with a long course of disease and in the inactive phase.Patients are prone to pain in their limbs.The CT A manifestations of these patients are also special,that is,the involved peripheral arteries are not prone to lumen dilatation and wall calcification.

Objective:To study the correlation between adverse clinical outcomes and early postnatal weight loss(representing the results of fluid management) during hospitalization in extremely premature infants(EPIs).Methods:From January 2019 to March 2023, EPIs (gestational age (GA)<28 weeks) admitted to neonatal intensive care unit(NICU) of our hospital were retrospectively analyzed. According to weight loss (WL) within the first 3 d after birth, the infants were assigned into no-WL group, WL<6% group, WL 6%-10% group and WL>10% group. The following items were compared among the four groups: fluid intake within the first 7 d after birth, the incidences of hemodynamically significant patent ductus arteriosus (hsPDA), PDA requiring surgical ligation, duration of invasive mechanical ventilation, ≥stage II necrotizing enterocolitis(NEC), grade 3-4 intraventricular hemorrhage(IVH), moderate bronchopulmonary dysplasia (BPD), severe BPD, mortality rates and total length of hospital stay.Results:A total of 119 EPIs were enrolled, including 41 in no-WL group, 22 in WL<6% group, 31 in WL 6%-10% group and 25 in WL>10% group. Among the four groups, no significant differences existed in fluid intake on d1 and d5-d7 after birth ( P>0.05). WL 6%-10% and >10% groups had significantly lower fluid intake during d2-d4 than no-WL group ( P<0.05).On d4, WL 6%-10% and >10% groups had lower fluid intake than WL <6% and no-WL groups( P<0.05).WL 6%-10% and >10% groups showed lower incidences of hsPDA than no-WL group ( P<0.05).WL>10% group had lower incidences of ≥stage II NEC, moderate BPD, shorter duration of invasive mechanical ventilation and total hospital stay than no-WL group( P<0.05). No significant differences existed in the incidences of PDA requiring surgical ligation, grade 3-4 IVH, severe BPD and mortality rates among the four groups ( P>0.05). Conclusions:For EPIs, a certain degree of WL within the first 3 d after birth is beneficial to reduce the incidences of hsPDA, NEC, moderate BPD, duration of invasive mechanical ventilation and total hospital stay. Focusing on body weight is helpful for a more optimal fluid management strategy in the early postnatal period.

Taking Wuzhou as an example,this paper investigates the construction of the standardized Party affairs system in public hospitals and the path for enhancing Party building quality.It clarifies the connotations and relationships of Party build-ing,Party affairs,and Party affairs standardization,and elaborates on the necessity and path of Party affairs standardization.Sub-sequently,an analysis of the current situation and existing problems,such as insufficient understanding,weak implementation,limited capabilities,and poor integration,is presented.Then,improvement measures,including Party committee guidance,pre-cise training,system construction,and practical promotion of relevant work,are proposed.Finally,the paper discusses the con-struction and improvement of the standardized Party affairs system,team building,and the deep integration of Party building and hospital operations,providing a reference for improving Party building quality in public hospitals.

Objectives:To explore the risk factors of blood loss and blood transfusion requirements in limit-ed resection for spinal metastases of lung cancer.Methods:The data of 97 patients who underwent limited resection for spinal metastases of lung cancer in Guangdong Provincial People's Hospital from January 1,2017 to December 31,2022 were continuously collected,including 61 males and 36 females,aged 60.2±10.1 years old.The gender,body mass index(BMI),operative time,number of internal fixation screws,number of decompressed segments,epidermal growth factor receptor(EGFR)mutation,lung cancer pathology,preoperative chemotherapy status,bone metastasis at first diagnosed,location segment of metastasis,type of surgical proce-dure,epidural spinal cord compression(ESCC)classification,preoperative 48-hour international normalized ratio(INR),preoperative 48-hour red blood cell(RBC)count,preoperative 48-hour white blood cell(WBC)count,preoperative 48-hour preoperative platelet count,preoperative 48-hour blood calcium level,the Revised-Tokuhashi prognostic score were collected.Univariate and multivariate linear regression analyses were em-ployed to assess the impact of various factors on intraoperative blood loss,while univariate and multivariate logistic regression analyses were utilized to evaluate the influence of different factors on the transfusion re-quirement.Results:Intraoperative blood loss ranged from 20 to 4800 mL(mean 916±939mL),and 56 patients required intraoperative blood transfusion.Compared to patients without transfusion,those requiring blood trans-fusion had a higher number of pedicle screws implanted,a greater proportion of EGFR mutation,a lower pro-portion of bone metastasis at first diagnosed,a higher proportion of thoracic vertebra metastases,and lower preoperative 48-hour RBC count.Significant factors influencing intraoperative blood loss included operative duration(β=107.1,P=0.026),number of pedicle screws implanted(β=108.3,P=0.023),and EGFR mutation(β=369.7,P=0.048).Significant factors associated with transfusion requirements included the number of pedicle screws implanted[odds ratio(OR)=1.7,95％confidence interval(CI)=1.2-2.3,P=0.001],EGFR mutation(OR=0.1,95％CI=0.0-0.5,P=0.003),bone metastasis at first diagnosed(OR=3.8,95％CI=1.2-11.9,P=0.023),and preop-erative 48-hour RBC count(OR=0.3,95％CI=0.1-0.7,P=0.009).Conclusions:Increased surgical invasiveness and the presence of EGFR mutation were associated with greater intraoperative blood loss and transfusion re-quirements in patients undergoing limited resection for spinal metastases of lung cancer.Additionally,patients with non-bone metastasis at first diagnosed exhibited higher transfusion requirements.

Ligand-gated ion channels transduce chemical signals into ionic currents while being bonded with specific ligands,thereby facilitating signal transduction and intercellular communication.These channels have become critical therapeutic targets for a variety of diseases.Ginsenosides,triter-penoid saponins primarily derived from herbs of the Panax genus,are known for their broad range of biological activities.Ginsenosides and their metabolites can regulate the functions of various ligand-gated ion channels,including nicotinic acetylcholine receptors,5-hydroxytryptamine type-3 receptors,γ-aminobu-tyric acid type-A receptors,glycine receptors,ionotropic glutamate receptors,ATP-gated P2X chan-nels,and transient receptor potential channels.They play important roles in anti-inflammation,analge-sics,immune regulation,anti-epilepsy,cognitive enhancement and neuroprotection.Further investiga-tion into the mechanisms by which ginsenosides regulate these channels will provide important evidence for their clinical applications and the development of new drugs.

Objectives:To explore the risk factors of blood loss and blood transfusion requirements in limit-ed resection for spinal metastases of lung cancer.Methods:The data of 97 patients who underwent limited resection for spinal metastases of lung cancer in Guangdong Provincial People's Hospital from January 1,2017 to December 31,2022 were continuously collected,including 61 males and 36 females,aged 60.2±10.1 years old.The gender,body mass index(BMI),operative time,number of internal fixation screws,number of decompressed segments,epidermal growth factor receptor(EGFR)mutation,lung cancer pathology,preoperative chemotherapy status,bone metastasis at first diagnosed,location segment of metastasis,type of surgical proce-dure,epidural spinal cord compression(ESCC)classification,preoperative 48-hour international normalized ratio(INR),preoperative 48-hour red blood cell(RBC)count,preoperative 48-hour white blood cell(WBC)count,preoperative 48-hour preoperative platelet count,preoperative 48-hour blood calcium level,the Revised-Tokuhashi prognostic score were collected.Univariate and multivariate linear regression analyses were em-ployed to assess the impact of various factors on intraoperative blood loss,while univariate and multivariate logistic regression analyses were utilized to evaluate the influence of different factors on the transfusion re-quirement.Results:Intraoperative blood loss ranged from 20 to 4800 mL(mean 916±939mL),and 56 patients required intraoperative blood transfusion.Compared to patients without transfusion,those requiring blood trans-fusion had a higher number of pedicle screws implanted,a greater proportion of EGFR mutation,a lower pro-portion of bone metastasis at first diagnosed,a higher proportion of thoracic vertebra metastases,and lower preoperative 48-hour RBC count.Significant factors influencing intraoperative blood loss included operative duration(β=107.1,P=0.026),number of pedicle screws implanted(β=108.3,P=0.023),and EGFR mutation(β=369.7,P=0.048).Significant factors associated with transfusion requirements included the number of pedicle screws implanted[odds ratio(OR)=1.7,95％confidence interval(CI)=1.2-2.3,P=0.001],EGFR mutation(OR=0.1,95％CI=0.0-0.5,P=0.003),bone metastasis at first diagnosed(OR=3.8,95％CI=1.2-11.9,P=0.023),and preop-erative 48-hour RBC count(OR=0.3,95％CI=0.1-0.7,P=0.009).Conclusions:Increased surgical invasiveness and the presence of EGFR mutation were associated with greater intraoperative blood loss and transfusion re-quirements in patients undergoing limited resection for spinal metastases of lung cancer.Additionally,patients with non-bone metastasis at first diagnosed exhibited higher transfusion requirements.

Ligand-gated ion channels transduce chemical signals into ionic currents while being bonded with specific ligands,thereby facilitating signal transduction and intercellular communication.These channels have become critical therapeutic targets for a variety of diseases.Ginsenosides,triter-penoid saponins primarily derived from herbs of the Panax genus,are known for their broad range of biological activities.Ginsenosides and their metabolites can regulate the functions of various ligand-gated ion channels,including nicotinic acetylcholine receptors,5-hydroxytryptamine type-3 receptors,γ-aminobu-tyric acid type-A receptors,glycine receptors,ionotropic glutamate receptors,ATP-gated P2X chan-nels,and transient receptor potential channels.They play important roles in anti-inflammation,analge-sics,immune regulation,anti-epilepsy,cognitive enhancement and neuroprotection.Further investiga-tion into the mechanisms by which ginsenosides regulate these channels will provide important evidence for their clinical applications and the development of new drugs.

Objective:To analyze the prognostic factors and evaluate the accuracy of existing survival prediction models in patients with lung cancer-derived spinal metastases who have undergone open surgery.Methods:According to the inclusion criteria, the data of 76 patients with spinal metastasis of lung cancer who underwent open surgery in the department of Orthopedics in Guangdong Provincial People's Hospital were collected from January 2019 to November 2021. The relationship between the number of bone metastasis, pathological type, visceral metastasis, epidermal growth factor receptor mutation, serum alkaline phosphatase (ALP), hemoglobin (Hb), Frankel grade and postoperative survival time in 76 cases was analyzed by Cox logical regression analysis and Kaplan-Meier method to determine the potential prognostic factors. The accuracy of Tomita score, Tokuhashi revised score, Katagiri New score, New England Spinal Metastasis Score score (NESMS) and Skeletal Oncology Research Group (SORG) machine learning algorithm in predicting postoperative survival time was verified by drawing receiver operating characteristic (ROC) curve.Results:The median follow-up time of the patients was 18.0 months (2.3-36.0 months). The median survival time was 12.6 months [95% CI (10.8, 14.4)]. The survival rates at 6 and 12 months after operation were 71.6% and 52.0%, respectively. Multivariate regression analysis showed that ALP [ HR=0.23, 95% CI (0.11, 0.48), P<0.001], Hb [ HR=4.48, 95% CI (2.07, 9.70), P< 0.001] and EGFR mutation [ HR=2.22, 95% CI (1.04, 4.76), P=0.040] were independent predictors of prognosis. The accuracy of Tomita score, Tokuhashi revised score (2005), Katagiri New score and NESMS score in predicting 1-year mortality was 58.7%, 65.7%, 70.5% and 65% respectively, and the accuracy in predicting 6-month mortality was 63.7%, 62.2%, 61.2% and 56.8% respectively. The accuracy of SORG machine learning algorithm in predicting 1-year and 90 d mortality was 81.1%, 67.5%, respectively. Conclusion:No EGFR mutation, ALP>164 U/L and Hb≤125 g/L were risk factors affecting the survival of patients with spinal metastasis of lung cancer. SORG machine learning algorithm has good accuracy in predicting the postoperative survival rate of patients with lung cancer spinal metastasis.