Objective To investigate the factors affecting the early phase insulin secretion function in type 2 diabetes patients and guide the clinical improvement of islet function.Methods A total of 137 patients with type 2 diabetes mellitus were selected to undergo glucose tolerance test to determine multipoint blood glucose and C-peptide.According to the level of early insulin secretion index(IGI),secretion is divided into low IGI group,medium IGI group and high IGI group.Univariate and multivariate Logistic regression analysis was performed.Results Body mass index,fasting C-peptide,uric acid,triglyceride,steady-state model[3 cell secretion index and fatty liver in high IGI group were higher than those in low IGI group(P＜0.05).The 120-minute glucose and HBA1c in high IGI group were lower than those in low IGI group(P＜0.05).Body mass index,fasting C-peptide and fatty liver in medium IGI group were higher than those in low IGI group(P＜0.05).The 120-minute glucose and HBA1c in medium IGI group were higher than those in low IGI group(P＜0.05).Multi variate Logistic regression showed that glycosylated hemoglobin(OR=0.796,95％CI:0.676-0.938,P＜0.05)was an independent risk factor for IGI30,and the steady-state insulin resistance index(OR=3.161,95％CI:1.324-7.553,P＜0.05),triglyceride(OR=1.287,95％CI:1.005-1.650,P＜0.05)is a protective risk factor for IGI30.Conclusion Glycosylated hemoglobin is a risk factor for the secretion of pancreatic islet in early stage of type 2 diabetes mellitus.Insulin resistance is a protective factor for the secretion of early phase insulin function.