Background and purpose:Limbs soft tissue sarcoma(STS)is a common malignant tumor,and surgical resection is the main treatment method for it.The concept of barrier made us realize the blocking effect of natural barrier on STS,and we aimed to search for tissues that can act as barrier,and to perform complete resection of surgical margins around the tissue barrier.This study aimed to investigate the feasibility,safety and prognosis of barrier resection in the treatment of limbs STS.Methods:From December 2013 to September 2016,data of 72 patients who underwent barrier resection of STS of extremities in department of oncosurgery,Minhang Branch,Fudan University Shanghai Cancer Center were retrospectively analyzed,and the resection margin was sampled.All 72 patients underwent preoperative magnetic resonance imaging(MRI)or computed tomography(CT)design,and the physiological barrier or at least 3 cm distance was found outward from the anatomical location of the tumor.And en bloc excision was performed outside this barrier or at a distance of 3 cm.The influence of postoperative pathological margin,musculoskeletal tumor society(MSTS)score and postoperative complications on the patients were analyzed.The 1-and 3-year locoregional recurrence-free survival(LRFS)rates and sarcoma-specific survival(SSS)rates were evaluated,and the influencing factors were analyzed.This study was approved by the Ethics Committee of Fudan University Shanghai Cancer Center(number:1212117-12&1212117-12-1301).Results:All patients had negative margins.The 1-and 3-year LRFS rates were 98.2%and 93.3%,respectively.The 1-and 3-year SSS rates were 98.4%and 94.2%,respectively.The mean MSTS scores were 28.3 preoperatively and 25.5 postoperatively.Surgical complications were grade 1 to 2 in 20 cases and grade 3 in 1 case,and there were no grade 4 to 5 complications.Conclusion:Based on the combination of clinical,imaging and pathology data,barrier resection,including tumor resection and functional reconstruction,can be applied to the surgical treatment of STS,with good feasibility and safety,reliable margin and satisfactory local control.

Primary retroperitoneal sarcomas,due to its special anatomical structure and lack of specific clinical manifestations in early stages,often leads to delayed diagnosis.because of the lack of specific clinical manifestations.By the time patients present with noticeable symptoms or palpable masses during clinical examination,the tumors has typically grown significantly in size and exhibits invasive growth patterns,frequently involving adjacent organs.Surgical treatment often necessitates multivisceral en bloc resection,with combined resection and functional reconstruction of gastrointestinal organs becoming critical components of the procedure.The surgical management of primary retroperitoneal sarcoma is characterized by extensive resection scope,technical complexity,and challenges in achieving complete tumor removal with wide clear negative margins.Additionally,the high propensity for local recurrence further increases the complexity of patient management.Current research on surgical treatment strategies for primary retroperitoneal sarcoma,particularly systematic studies focusing on combined gastrointestinal resection and functional reconstruction,remains insufficient.To enhance clinical understanding and optimize surgical approaches,this article systematically reviews domestic and international literature to summarize current research status and recent advancements in combined gastrointestinal resection and functional reconstruction for primary retroperitoneal sarcoma.

Primary retroperitoneal sarcomas,due to its special anatomical structure and lack of specific clinical manifestations in early stages,often leads to delayed diagnosis.because of the lack of specific clinical manifestations.By the time patients present with noticeable symptoms or palpable masses during clinical examination,the tumors has typically grown significantly in size and exhibits invasive growth patterns,frequently involving adjacent organs.Surgical treatment often necessitates multivisceral en bloc resection,with combined resection and functional reconstruction of gastrointestinal organs becoming critical components of the procedure.The surgical management of primary retroperitoneal sarcoma is characterized by extensive resection scope,technical complexity,and challenges in achieving complete tumor removal with wide clear negative margins.Additionally,the high propensity for local recurrence further increases the complexity of patient management.Current research on surgical treatment strategies for primary retroperitoneal sarcoma,particularly systematic studies focusing on combined gastrointestinal resection and functional reconstruction,remains insufficient.To enhance clinical understanding and optimize surgical approaches,this article systematically reviews domestic and international literature to summarize current research status and recent advancements in combined gastrointestinal resection and functional reconstruction for primary retroperitoneal sarcoma.