Objective:To summarize the best evidence of ICU acquired weakness(ICUAW) clinical nursing strategies and measures in adult patients and provide evidence-based basis for clinical practice.Methods:By using "6S" evidence model, related literature on ICUAW prevention and management was systematically retrieved from UpToDate, BMJ Best Practice, the National Guideline Clearinghouse, the National Institute for Health and Care Excellence, the Registered Nurses′ Association of Ontario, Cochrane Library, PubMed, Yimaitong Guidelines, CNKI, Wanfang Data, VIP and China Biomedical Literature Database, the retrieval time was from the establishment of the database to september 30, 2023. Two researchers who receieved evidence-based nursing training was independently completed literature quality evaluation. The evidence of the literature were extracted and summarized.Results:Totally, 17 articles were included, including 3 guidelines, 3 expert consensus, 4 systematic review/Meta analysis, 2 crosssectional studies and 5 randomized controlled trials. A total of 30 pieces of best evidence were constructed, including intervention evaluation, daily awakening, safety standards, rehabilitation time, rehabilitation content, rehabilitation intensity, precautions, bundled management, blood pressure/blood glucose control.Conclusions:The present study summarized the best evidence of nursing strategies and measures for adult ICUAW, medical staff should transform and apply the best evidence in combination with clinical contexts to reduce the adverse prognosis of ICUAW.

Objective:To summarize the best evidence of ICU acquired weakness(ICUAW) clinical nursing strategies and measures in adult patients and provide evidence-based basis for clinical practice.Methods:By using "6S" evidence model, related literature on ICUAW prevention and management was systematically retrieved from UpToDate, BMJ Best Practice, the National Guideline Clearinghouse, the National Institute for Health and Care Excellence, the Registered Nurses′ Association of Ontario, Cochrane Library, PubMed, Yimaitong Guidelines, CNKI, Wanfang Data, VIP and China Biomedical Literature Database, the retrieval time was from the establishment of the database to september 30, 2023. Two researchers who receieved evidence-based nursing training was independently completed literature quality evaluation. The evidence of the literature were extracted and summarized.Results:Totally, 17 articles were included, including 3 guidelines, 3 expert consensus, 4 systematic review/Meta analysis, 2 crosssectional studies and 5 randomized controlled trials. A total of 30 pieces of best evidence were constructed, including intervention evaluation, daily awakening, safety standards, rehabilitation time, rehabilitation content, rehabilitation intensity, precautions, bundled management, blood pressure/blood glucose control.Conclusions:The present study summarized the best evidence of nursing strategies and measures for adult ICUAW, medical staff should transform and apply the best evidence in combination with clinical contexts to reduce the adverse prognosis of ICUAW.

Objectives: To explore the expression regulation of type 1 and type 2 (Th1 and Th2) cytokines from serum of coal miners and the evaluation in surveillance of coal workers' pneumoconiosis, 630 coal miners were studied. Methods: A total of 90 male patients diagnosed as coal workers' pneumoconiosis (CWP) in a institute for occupational health and 19 male workers newly diagnosed as CWP patients was chosen as CWP group with simple random sampling method from a coal mine group from January 2013 to December in 2015. 180 male coal miners with abnormal but not diagnosed as CWP were selected as CWP suspected group with simple random sampling methods, meanwhile 180 male coal miners with normal chest X-ray photograph was as dust-exposed group by 1∶1 matched as age. And 161 healthy males accepted pre-employed examination were selected as control group, CWP suspected group, dust-exposed group and control group called as non-CWP group. According to screening test and diagnosis test, the basic information and occupational history of all subjects were collected, and cytokines including IL-1β, IL-8, IFN-γ, IL-6 and IL-10 of serum were detected. Receiver operator characteristic (ROC) curve was used to determine the optimal cutoff value of each cytokine. Area under curve (AUC), the validity and reliability were calculated and judged. Results: The average age of control group, dust-exposed group, CWP suspected group and CWP group were (27.4±5.0) , (43.4±10.7) , (48.2±6.2) , (64.7±7.0) years old, respectively. The median level of IL-1β, IL-8, IFN-γ and IL-6 in cases group (1 638.30, 2 099.49, 815.18,140.32 pg/ml) were higher than that of non-cases group (1 445.57, 1 402.26, 736.38, 95.73 pg/ml) (P<0.05) . The level of IL-8 (1 503.99 pg/ml) in CWP suspected group was higher than that of control group (1 295.67 pg/ml) and dust-exposed group (1 376.94 pg/ml) , but the level of IL-10 (654.08 pg/ml) was lower than that of control group (596.64 pg/ml) . The ratio of IFN-γ/IL-6 ranged from 5 to 8, and the ratio in CWP group (5.87) was lower than that of non-CWP group (7.61) . The IL-6 and IL-8 among the subjects of dust-exposed group in terms of the age distribution of among had reached statistical significance. According to ROC, the cutoff value of IL-1β, IL-6, IL-8, IL-10 and INF-γ reached 1 582.65, 116.53, 1 791.54, 581.08 and 792.69 pg/ml, respectively. The AUC was 0.668, 0.895, 0.859, 0.716 and 0.637, respectively. It was found that IL-6 and IL-8 could be used as biomarkers in detecting CWP, the sensitivity and specificity was 82.6% and 84.6%, 78.0% and 84.8%, respectively; Youden's index was 0.674 and 0.628 and the consistency rate was 84.3% and 83.7%, while Kappa value was 0.55 and 0.52. Conclusion There was Type 1 and type 2 cytokine dysregulation in CWP patients. IL-6 and IL-8 can be used as effective biomarkers to forecast lung injury before X-ray changes.