Objective To explore the correlations of serum interleukin-4(IL-4),leptin and chemerin levels with severity of asthma in obese children and their predictive values for asthma control.Methods A total of 102 obese children with asthma were selected as study group,and another 102 healthy obese children were selected as control group.The serum levels of IL-4,leptin and chemerin were compared between the two groups.The study group was divided into mild(n=34),moderate(n=42)and severe(n=26)asthma groups based on severity of disease,and the serum levels of IL-4,leptin and chemerin were compared among different groups.The correlations of serum IL-4,leptin and chemerin with disease severity were analyzed.After 4 weeks of treatment,the 102 children with asth-ma were divided into controlled group(n=82)and uncontrolled group(n=20)based on asthma con-trol status.Clinical data and serum levels of IL-4,leptin and chemerin were compared between the two groups,and their impacts on asthma control were analyzed.The predictive values of serum IL-4,leptin and chemerin levels for asthma control were evaluated.Results The serum levels of IL-4,leptin and chemerin showed significant gradual increase trends among controlled children,mild asthma children,moderate asthma children,and severe asthma children(P＜0.001).Spearman correlation analysis showed positive correlations of serum IL-4,leptin and chemerin with disease severity(P＜0.001).The serum levels of IL-4,leptin and chemerin in the uncontrolled group were significantly higher than those in the controlled group(P＜0.001).Logistic regression analysis showed that serum IL-4(OR=1.514,95％CI,1.117 to 2.051),leptin(OR=1.534,95％CI,1.234 to 1.907),and chemerin(OR=1.418,95％CI,1.026 to 1.959)after adjusting for disease duration were still the independent risk factors for asthma control(P＜0.05).The areas under the curve(AUC)for pre-dicting asthma control by single and combined detections of serum IL-4,leptin and chemerin were 0.807(95％CI,0.717 to0.879),0.801(95％CI,0.711 to0.874),0.834(95％CI,0.748 to 0.901)and 0.932(95％CI,0.864 to 0.972),respectively.The AUC for combined prediction was significantly better than that for individual predictor(P＜0.05).Conclusion The serum lev-els of IL-4,leptin and chemerin in obese children with asthma are positively correlated with disease severity,and they are independent risk factors for asthma control.Combined detection of these three indicators has a higher predictive value for asthma control.