Objective To explore the effect of different packing contents of solid phase extraction column, repeated use times and solid phase extraction column under pressure on the determination of morphine content in compound liquorice oral solution. Methods The component was performed by high performance liquid chromatography （HPLC） equipped with the C₈ （4.6 mm × 150 mm, 5 μm） chromatographic column. The mobile phase consisted of acetonitrile-2.5 mmol/L sodium heptanesulfonate solution-50 mmol/L potassium dihydrogen phosphate solution （5∶18∶18）. The flow rate was 1.0 ml/min with the 220 nm detection wavelength, 20 μl injection volume and 30℃ column temperature. Results It was found that the SPE column produced of 500 mg had a higher recovery rate of morphine, and the RSD value was small. It was found that SPE column could be reused for up to 3 times under the condition of guaranteeing recovery rate.In the pressurized experiment,at the flow rate of 0.5 ml/min, the measured morphine content was basically consistent with that measured at atmospheric pressure. Conclusion The determination of morphine in compound liquorice oral solution could be carried out by C₁₈ solid phase extraction column of 500 mg. Under pressure, the flow rate was about 0.5 ml/min for morphine recovery, which could achieve high recovery of morphine in compound liquorice oral solution and improve the detection efficiency of morphine.

Hepatocellular carcinoma(HCC)is the most common primary liver cancer and the third leading cause of cancer-related deaths worldwide.Despite continuous advancements in diagnostic and therapeutic technologies in recent years,the overall treatment outcomes for HCC remain to be improved.With the advancement of artificial intelligence,radiomics has emerged as an innovative approach by extracting quantitative features from medical images imperceptible to the naked eye,enabling predictive modeling for the diagnosis,treatment decision-making,therapeutic evaluation,and prognostic prediction of HCC.This article systematically reviews the application of radiomics in the intelligent management of HCC,based on the latest research progress,aiming to enhance comprehensive treatment strategies.

Hepatocellular carcinoma(HCC)is the most common primary liver cancer and the third leading cause of cancer-related deaths worldwide.Despite continuous advancements in diagnostic and therapeutic technologies in recent years,the overall treatment outcomes for HCC remain to be improved.With the advancement of artificial intelligence,radiomics has emerged as an innovative approach by extracting quantitative features from medical images imperceptible to the naked eye,enabling predictive modeling for the diagnosis,treatment decision-making,therapeutic evaluation,and prognostic prediction of HCC.This article systematically reviews the application of radiomics in the intelligent management of HCC,based on the latest research progress,aiming to enhance comprehensive treatment strategies.

Objective To establish a method that could detect 5 components of Fufang Heishen oral liquid simultaneously. Methods The component was performed by high performance liquid chromatography ( HPLC) equipped with Agilent Hypersil ODS (4.6 mm×250 mm,5 μm).The mobile phase consisted of acetonitrile-0.1% Phosphoric acid with gradient elution.The flow rate was 1.0 mL·min-1with the 210 nm and 270 nm detection wavelength,20 μL injection volume and 30 ℃column temperature. Results A good linear relationship was observed with the range of 7.12-85.44 mg·L-1for Harpagide (r＝0.999 9),2.50-30.00 mg·L-1for Harpagoside(r＝0.999 8),25.35-304.20 mg·L-1for Cinnamic acid(r＝0.999 7),0.73-8.70 mg·L-1for Tectoridin(r＝0.999 7)and 1.20-14.40 mg·L-1for Irisflorentin(r＝0.999 8).The average recovery of each detected component of Fufang Heishen Oral Liquid was 98.8%,102.7%,98.8%,99.3%,99.9% the RSD were 1.23%,2.89%, 2.60%,1.44%,2.84%(n＝6). Conclusion The method is simple,rapid and accurate and can be used to detect the content of Harpagide,Harpagoside,Cinnamic acid,Tectoridin and Irisflorentin of Fufang Heishen Oral Liquid.

Objective To establish a quality standard for compound Heishen granules .Methods Scrophulariae Radix and Belamcandae Rhizoma were identified by TLC .HPLC was used to determine the content of cinnamic acid ,tectoridin and irisflo-rentin .The HPLC was performed on a column of Kromasil-C18 (150 mm × 4 .6 mm ,5 μm)with a mobile phase of acetonitrile (A)-0 .1％ hydrochloric acid (B)at a temperature 30 ℃ .The detection wavelength was set at 270 nm and the flow rate at 1 ml/min .Results The TLC method had good specificity without interference from negative control .The calibration curve showed a good linear relationship within the range of 16 .22-113 .57μg/ml for cinnamic acid(r=0 .9998) ,48 .19-337 .34μg /ml for tectoridin(r= 0.9998)and 16.40-114.80 μg/ml for irisflorentin(r= 0.9999) .The average recoveries were 99.23％ , 98.82％ ,99.17％ .Conclusion The established method is rapid ,accurate and reproducible .It can be used in the quality control of compound Heishen granules .

Objective:To optimize and improve the content determination method for nitroglycerin ointment. Methods:An HPLC method was used,the column was Hypersil ODS(150 mm × 4. 6 mm,5 μm),the mobile phase was acetonitrile ∶water(50 ∶50),the detection wavelength was set at 220 nm,the flow rate was 1 ml·min-1 ,the column temperature was 30℃,and the injection volume was 20 μl. Results: The results showed a good linear relationship within the concentration range of 0. 020 3-0. 203 3 mg · ml-1 ( r =0. 999 9),and the average recovery was 99. 51%(RSD=1. 06%,n=9). Conclusion: The method is rapid,accurate and reproduci-ble,and can be used to determine the content of nitroglycerin in nitroglycerin ointment.

Objective To explore the application effect of the whole process quality control on the Da Vinci surgical instruments cleaning. Methods Using objective sampling method, 312 Da Vinci surgical instruments handled from July 2016 to September 2016 were selected as the control group, while 513 instruments handled from October 2016 to December 2016 were recruited into the observation group. The control group used routine cleaning and sterilization method. Meanwhile, the observation group received the whole process quality control. The rate of re-cleaning for Da Vinci surgical instruments were compared between two groups. Results The rate of re-cleaning for Da Vinci surgical instruments was 3.8% in the control group, which was higher than that (1.8%) in the observation group. The difference between two groups was statistically significant (χ2=3.423, P<0.05). Conclusions The application of the whole process quality control on the Da Vinci surgical instruments cleaning can improve the service quality of central sterile supply and guarantee the smooth process of Da Vinci-assisted surgery.

As the increase in demand of medical support for military missions in recent years, field operations infection clinic acts as a major power to perform a task in infection support medical security during the war. The field operations infection clinic plays an important role in the wounded infection control and outbreak control as well as builds a materials quality traceability system for tracking and recording the quality safety of surgical instruments. It is vital to ensure the treatment security of the wounded. The role of central sterile supply department is very important which acts as the responsibility undertaker for ensuring and providing medical ambulance supplies with pasteurization and sterilization for medical task. The reusable surgical instruments quality traceability system has been widely used in central sterile supply department of class Ⅲ grade A hospitals in China. This study summarized the information traceability of surgical instruments during medical support at home and abroad.

Objective To establish and validate a method of sterility test for nitroglycerin ointment and validate this method .Methods Ten nitroglycerin ointments of 1 g were preheated oven to 45 ℃ for sample ,and added to conical flask which containing melted span 80 ,polysorbate 80 sterile mixture and sterile glass beads ,and were shake after mixing ,the sample fully emulsified by adding to 100 ml 45 ℃ pH 7 .0 sterile sodium chloride-peptone water buffer .According to the method of mem-brane filtration ,bacteria and fungus in each membrane with 300 ml pH 7 .0 sterile sodium chloride-peptone water buffer flush , the bacteriostatic activity was eliminated .Results By the method validation ,nitroglycerin ointment sample group ,negative control group were sterile growth ,and test group in each filter of the test bacteria compared with control groups were growing well ,so the samples had no inhibitory effect or the antimicrobial effect would not take into account .Conclusion Membrane fil-tration was reliable ,which could be used for sterility test for nitroglycerin ointment .

Objective To explore the application effect of whole processquality control on the management of precision and valuable equipment. Methods According to ‘Technical Standard for Disinfection’ , quality monitoring was conducted in the whole process of the operation room for precision and valuableequipment. Results After the whole course quality control, precision and valuable equipment processing quality qualified rate 99. 85%, damage rate from 0. 60% decreased to 0. 25%. The quality of nurses and nursing qualitywere improved. Conclusions The whole process quality control is effective measures to ensure the qualified rate of precision and valuable equipment.