In order to effectively integrate scientific research data resources and improve data utilization, the National Clinical Medical Research Center had built a "3321" -integration big data sharing innovation platform. By providing full support to scientific research, sorting out the distribution mechanism of achievements, and formulating authority management norms, the big data platform had solved the weaknesses in data sharing ability, sharing willingness, and sharing security, giving full play to the effectiveness of the clinical research big data platform. By February 2022, the center had collected more than 1.04 million elderly patients data through the big data platform, as well as carried out 75 scientific research projects, and established 10 large population-based clinical research queues. The big data platform had realized full coverage of major diseases in the field of geriatric diseases, promoted the high-quality construction of the national clinical medical research center, and improved the scientific research and innovation ability of the cooperative units.

Objective:To investigate the clinical efficacy of emergency bundle combined with hyperbaric oxygen therapy for patients with carbon monoxide poisoning and to analyze prognostic risk factors.Methods:A total of 116 patients with carbon monoxide poisoning treated in Linyi Central hospital from February 2015 to May 2020 were selected retrospectively and divided into control group and treatment group according to different treatment methods，with 58 cases in each group. The control group was treated with hyperbaric oxygen，and the treatment group was treated with emergency bundle on the basis of the treatment of the control group. The clinical efficacy of the two groups were observed and compared.Results:The total effective rate of the treatment group（93.10%）was significantly higher than that of the control group（77.59%），and the difference was statistically significant（ P<0.05）. There was no significant difference in respiratory rate（RR），arterial partial pressure of oxygen（PaO 2），and blood oxygen saturation（SaO 2）between two groups before treatment（ P > 0.05）. After treatment，the respiratory rate（RR），arterial partial pressure of oxygen（PaO 2），and blood oxygen saturation（SaO 2）were improved in two groups compared with those before treatment，and the treatment group was better than the control group，with statistical significance（ P < 0.05 or P < 0.01）. The coma time（≧24 h），abnormal EEG，hyperbaric oxygen treatment time（≧7 d），abnormal head CT and CO exposure time（≧3 h）in two groups were the main factors affecting the prognosis of CO poisoning（ P < 0.01）. Furthermore，coma time，hyperbaric oxygen treatment time，and abnormal head CT were the risk factors affecting the prognosis of CO poisoning（ P < 0.05 or P < 0.01）. Conclusion:Emergency bundle combined with hyperbaric oxygen therapy has a good clinical effect on patients with carbon monoxide poisoning. It can effectively improve the SaO 2 and PaO 2 of patients. The coma time，hyperbaric oxygen treatment time，and abnormal head CT were the risk factors affecting the prognosis of CO poisoning.

Objective:To investigate the clinical efficacy of emergency bundle combined with hyperbaric oxygen therapy for patients with carbon monoxide poisoning and to analyze prognostic risk factors.Methods:A total of 116 patients with carbon monoxide poisoning treated in Linyi Central hospital from February 2015 to May 2020 were selected retrospectively and divided into control group and treatment group according to different treatment methods，with 58 cases in each group. The control group was treated with hyperbaric oxygen，and the treatment group was treated with emergency bundle on the basis of the treatment of the control group. The clinical efficacy of the two groups were observed and compared.Results:The total effective rate of the treatment group（93.10%）was significantly higher than that of the control group（77.59%），and the difference was statistically significant（ P<0.05）. There was no significant difference in respiratory rate（RR），arterial partial pressure of oxygen（PaO 2），and blood oxygen saturation（SaO 2）between two groups before treatment（ P > 0.05）. After treatment，the respiratory rate（RR），arterial partial pressure of oxygen（PaO 2），and blood oxygen saturation（SaO 2）were improved in two groups compared with those before treatment，and the treatment group was better than the control group，with statistical significance（ P < 0.05 or P < 0.01）. The coma time（≧24 h），abnormal EEG，hyperbaric oxygen treatment time（≧7 d），abnormal head CT and CO exposure time（≧3 h）in two groups were the main factors affecting the prognosis of CO poisoning（ P < 0.01）. Furthermore，coma time，hyperbaric oxygen treatment time，and abnormal head CT were the risk factors affecting the prognosis of CO poisoning（ P < 0.05 or P < 0.01）. Conclusion:Emergency bundle combined with hyperbaric oxygen therapy has a good clinical effect on patients with carbon monoxide poisoning. It can effectively improve the SaO 2 and PaO 2 of patients. The coma time，hyperbaric oxygen treatment time，and abnormal head CT were the risk factors affecting the prognosis of CO poisoning.