Objective To explore the level of blood uric acid in patients with knee osteoarthritis pain, so as to provide acces-sory diagnosis of osteoarthritis ( OA) .Methods From Oct of 2010 to Dec of 2015, 1174 patients who complained of osteoarthritis pain were recruited through the Outpatient Department.Fasting blood samples were collected for the detection of uric acid level, and VAS scores were used to assess the severity of osteoarthritis pain.Results One thousand one hundred and seventy-four subjects (250 males and 924 females) were divided into 2 groups.The blood uric acid level for the females was(277.08 ±67.07)μmol/L, while the uric acid level for the males was(347.31 ±88.48)μmol/L, and statistical significance could be seen, when comparisons were made be-tween them( P<0.01) .The level of uric acid P25 of the females was 232μmol/L, while that of the males was 295μmol/L.The uric acid of the females increased with the increase of age, while that of the males below the age of 70 decreased with the increase of age.In the females, the VAS scores increased with the increase of uric acid level, and the higher the VAS scores, the higher the uric acid lev-el, and statistical significance could be noted, when comparisons were made between them (P<0.001).Results indicated that there was association between VAS scores and uric acid level for the males.Conclusion When the uric acid level for the male was above 295μmol/L and that for the female was above 232 μmol/L, it was of clinical significance for the diagnosis of osteoarthritis.The uric acid level of the females increased with the increase of age and the elevation of VAS scores, indicating that efforts should be made on the part of females to control their food intake.