Arterial thrombosis is a major cause of death in several cardiovascular diseases(CVDs),including coronary heart disease and stroke.Since platelets play a pivotal role in arterial thrombosis,antiplatelet drug is an important part of the clinical therapy of CVD patients.Currently,the long-term antithrombotic effect of the dual antiplatelet thera-py of P2Y12 antagonists combined with aspirin are showed to be effective.And αⅡbβ3 antagonists rep-resented by tirofiban are widely used for antiplate-let therapy in emergency surgery.However,the bleeding risk caused by antiplatelet therapy is a clinical issue that cannot be ignored.In order to provide a reference for further research on anti-platelet drugs,this article reviews the major tar-gets of antiplatelet drugs and the drugs that have been under clinical research in recent years.

Arterial thrombosis is a major cause of death in several cardiovascular diseases(CVDs),including coronary heart disease and stroke.Since platelets play a pivotal role in arterial thrombosis,antiplatelet drug is an important part of the clinical therapy of CVD patients.Currently,the long-term antithrombotic effect of the dual antiplatelet thera-py of P2Y12 antagonists combined with aspirin are showed to be effective.And αⅡbβ3 antagonists rep-resented by tirofiban are widely used for antiplate-let therapy in emergency surgery.However,the bleeding risk caused by antiplatelet therapy is a clinical issue that cannot be ignored.In order to provide a reference for further research on anti-platelet drugs,this article reviews the major tar-gets of antiplatelet drugs and the drugs that have been under clinical research in recent years.