Objective To construct a transparent and visualized bionic model of human utricle and explore the biomechanical response of the utricle to linear acceleration.Methods Using three-dimensioanl(3D)printing technology and PVA-gelatin composite hydrogel fabrication method,a visual physical model of the utricle with a ratio of 10∶1 to the human body was successfully prepared.The biomechanical response of the utricle macula was investigated by varying acceleration and direction stimulation experiments.Results Under 1-5 Hz sinusoidal reciprocating linear excitation,the response amplitude of the bionic macula increased from 4.11 μm to 48.82 μm.The response amplitude of the bionic macula increased linearly with the acceleration.In addition,the macula showed deformation differences in response to acceleration in a specific direction.Conclusions The bionic utricle model prepared in this study can accurately simulate the working mechanism of human utricle,which is expected to provide a new way for the pathological study of vestibular dysfunction and expand a new direction for the application of bionic technology in the field of biomedical engineering.

Objective To construct a transparent and visualized bionic model of human utricle and explore the biomechanical response of the utricle to linear acceleration.Methods Using three-dimensioanl(3D)printing technology and PVA-gelatin composite hydrogel fabrication method,a visual physical model of the utricle with a ratio of 10∶1 to the human body was successfully prepared.The biomechanical response of the utricle macula was investigated by varying acceleration and direction stimulation experiments.Results Under 1-5 Hz sinusoidal reciprocating linear excitation,the response amplitude of the bionic macula increased from 4.11 μm to 48.82 μm.The response amplitude of the bionic macula increased linearly with the acceleration.In addition,the macula showed deformation differences in response to acceleration in a specific direction.Conclusions The bionic utricle model prepared in this study can accurately simulate the working mechanism of human utricle,which is expected to provide a new way for the pathological study of vestibular dysfunction and expand a new direction for the application of bionic technology in the field of biomedical engineering.