Objective To design a visual command and management platform for hospitals to provide technical support for the unified management and command of people,events and materials in hospitals.Methods A hospital visual command and management platform based on 3D visualization technology was designed with the B/S architecture and developed with the front-end and back-end separation mode.The front end was realized with Vue+three.js framework,and the back end based on the SpringCloud microservice architecture was implemented with Java language.The platform developed was composed of three systems for visual display,integrated situation monitoring and command management.Results The platform developed realized intuitive display,real-time dynamic monitoring and efficient arrangement and command for kinds of data resources and different businesses in hospitals,and enhanced hospital emergency command and management efficiency and patient experience.Conclusion The platform developed meets the requirements of hospitals in command and management,and comprehensively improves the operation and management efficiency of hospitals.[Chinese Medical Equipment Journal,2025,46(6):42-46]

Objective To investigate the effect of ClearInfinity deep learning reconstruction algorithm on image quality and radiation dose of abdominal computed tomography angiography(CTA)at low kV and low contrast medium.Methods One hundred patients who underwent abdominal CTA were selected and randomly divided into group A and group B.Group A:tube voltage 70 kV,con-trast medium 30-35 mL,divided into A1 and A2 subgroups according to reconstruction algorithm,group A1 50%ClearInfinity,group A2 50%ClearView iterative algorithm;group B:tube voltage 100 kV,contrast medium 60-70 mL,50%ClearView.CT values and standard deviation(SD)values of region of interest(ROI)of abdominal aorta,proper hepatic artery,superior mesenteric artery,renal artery and common iliac artery were evaluated objectively,while signal-to-noise ratio(SNR)and contrast-to-noise ratio(CNR)were calculated;subjective scores were evaluated by two physicians;radiation doses of groups A and B were analyzed.Results Volume CT dose index(CTDIvol),dose length product(DLP)and effective dose(ED)in group A were significantly lower than those in group B(P<0.05),subjective scores in group A1 and group B were higher than those in group A2(P<0.05),and there was no difference between group A1 and group B(P>0.05).Compared with group A1,SNR and CNR of all vessels in group A2 were significantly decreased.CT values of abdominal aorta and common iliac artery,CNR of common iliac artery and supe-rior mesenteric artery in group B were significantly increased,SNR of renal artery was significantly decreased(P<0.05).Conclusion ClearInfinity deep learning reconstruction algorithm combined with 70 kV scanning technology can obtain better abdom-inal CTA image quality,and effectively reduce the radiation dose and contrast medium of patients,which has high clinical application value.

Objective To investigate the effect of ClearInfinity deep learning reconstruction algorithm on image quality and radiation dose of abdominal computed tomography angiography(CTA)at low kV and low contrast medium.Methods One hundred patients who underwent abdominal CTA were selected and randomly divided into group A and group B.Group A:tube voltage 70 kV,con-trast medium 30-35 mL,divided into A1 and A2 subgroups according to reconstruction algorithm,group A1 50%ClearInfinity,group A2 50%ClearView iterative algorithm;group B:tube voltage 100 kV,contrast medium 60-70 mL,50%ClearView.CT values and standard deviation(SD)values of region of interest(ROI)of abdominal aorta,proper hepatic artery,superior mesenteric artery,renal artery and common iliac artery were evaluated objectively,while signal-to-noise ratio(SNR)and contrast-to-noise ratio(CNR)were calculated;subjective scores were evaluated by two physicians;radiation doses of groups A and B were analyzed.Results Volume CT dose index(CTDIvol),dose length product(DLP)and effective dose(ED)in group A were significantly lower than those in group B(P<0.05),subjective scores in group A1 and group B were higher than those in group A2(P<0.05),and there was no difference between group A1 and group B(P>0.05).Compared with group A1,SNR and CNR of all vessels in group A2 were significantly decreased.CT values of abdominal aorta and common iliac artery,CNR of common iliac artery and supe-rior mesenteric artery in group B were significantly increased,SNR of renal artery was significantly decreased(P<0.05).Conclusion ClearInfinity deep learning reconstruction algorithm combined with 70 kV scanning technology can obtain better abdom-inal CTA image quality,and effectively reduce the radiation dose and contrast medium of patients,which has high clinical application value.

Objective To design a visual command and management platform for hospitals to provide technical support for the unified management and command of people,events and materials in hospitals.Methods A hospital visual command and management platform based on 3D visualization technology was designed with the B/S architecture and developed with the front-end and back-end separation mode.The front end was realized with Vue+three.js framework,and the back end based on the SpringCloud microservice architecture was implemented with Java language.The platform developed was composed of three systems for visual display,integrated situation monitoring and command management.Results The platform developed realized intuitive display,real-time dynamic monitoring and efficient arrangement and command for kinds of data resources and different businesses in hospitals,and enhanced hospital emergency command and management efficiency and patient experience.Conclusion The platform developed meets the requirements of hospitals in command and management,and comprehensively improves the operation and management efficiency of hospitals.[Chinese Medical Equipment Journal,2025,46(6):42-46]

Objective To investigate the nutritional status of children with Crohn's Disease (CD) at diagnosis and its association with clinical characteristics. Methods A retrospective analysis was performed for the clinical data and nutritional status of 118 children with CD who were admitted to Beijing Children's Hospital,Capital Medical University,from January 2016 to January 2024. A multivariate logistic regression analysis was used to investigate the risk factors for malnutrition. Results A total of 118 children with CD were included,among whom there were 68 boys (57.6％) and 50 girls (42.4％),with a mean age of (11±4) years. Clinical symptoms mainly included recurrent abdominal pain (73.7％,87/118),diarrhea (37.3％,44/118),and hematochezia (32.2％,38/118),and 63.6％ (75/118) of the children had weight loss at diagnosis. The incidence rate of malnutrition was 63.6％ (75/118),and the children with moderate or severe malnutrition accounted for 67％ (50/75). There were 50 children (42.4％) with emaciation,8 (6.8％) with growth retardation,and 9 (7.6％) with overweight or obesity. Measurement of nutritional indices showed a reduction in serum albumin in 83 children (70.3％),anemia in 74 children (62.7％),and a reduction in 25 hydroxyvitamin D in 15 children (60％,15/25). The children with malnutrition had significantly higher disease activity,proportion of children with intestinal stenosis,and erythrocyte sedimentation rate and a significant reduction in serum albumin (P<0.05). The multivariate logistic regression analysis showed that intestinal stenosis was an independent risk factor for malnutrition in children with CD (OR=4.416,P<0.05). Conclusions There is a high incidence rate of malnutrition in children with CD at diagnosis,which is associated with disease activity and disease behavior. The nutritional status of children with CD should be closely monitored.

Objective To explore whether Astragalus polysaccharide can inhibit immune escape of T helper cells 17(Th17)and regulatory T cells(Treg)-mediated tumor cell immune escape in mice with bladder cancer by regulating the transforming growth factor-β1(TGF-β1)/FOXP3/retinoic acid receptor-associated orphan receptor-γT(RORγt)pathway.Methods Human bladder cancer cell line 5637 was injected into the BALB/c male nude mice to establish the model.After successful mold making,the model mice were randomly divided into model group,control group and experimental-L,-M,-H groups,10 mice per group;another 10 normal mice were taken as the blank group.The experimental-L,-M,-H groups were administered with stragalus polysaccharide solutions at doses of 100,200 and 300 mg·kg-1·d-1 by gavage,respectively.The model group and blank group were administered with 0.9％NaCl solution at a dose of 20 mL·kg-1·d-1 by gavage.The control group was administered with cisplatin at a dose of 5 mg·kg-1·d-1 by gavage.Six groups were treated for one month with once a day.After the drug,the tumor suppression was calculated.The cell apoptosis was determined by the TUNEL assay.The counts of Th1 and Treg cells were determined by flow cytometry.The expression levels of TGF-β1,FoxP3 and RORγt in bladder tissues were determined by Western blotting.Results The tumor weight of the experimental-H,the control group and the model group were(0.89±0.12),(0.67±0.09)and(2.09±0.31)g,respectively;the apoptosis indexes were(21.93±2.53)％,(23.91±2.18)％and(4.18±0.39)％,respectively.The contents of Treg cells in experimental-H group,control group,model group and blank group were(3.18±1.15)％,(2.97±0.98)％,(17.23±5.34)％and(2.73±1.04)％,respectively;the contents of Th7 cells were(1.03±0.36)％,(0.92±0.33)％,(6.28±1.96)％and(0.86±0.33)％,respectively;the relative expression levels of TGF-β1 protein were 0.34±0.13,0.33±0.11,0.69±0.10 and 0.32±0.08,respectively;the relative expression levels of FoxP3 protein were 0.21±0.05,0.20±0.06,0.72±0.16 and 0.19±0.06,respectively;the relative expression levels of RORγt protein were 0.34±0.12,0.32±0.12,0.66±0.17 and 0.36±0.09,respectively.Compared with experimental-H and control groups,the above indexes in the model group were statistically significant(all P＜0.05).Conclusion Astragalus polysaccharide can regulate the TGF-β1/FoxP3/RORγt pathway to inhibit Treg and Th7 cells-mediated immune evasion of bladder cancer in mice.

Objective To investigate the occurrence of adverse events of lurasidone in the U.S.Food and Drug Administration Adverse Event Reporting System(FAERS)database by using Open Vigil FDA2.1,to enrich the experience and provide the basis for the clinical use of the drug in China.Methods Using Open Vigil FDA2.1,adverse event data were extracted from the FAERS database for a total of 51 quarters from the 4th quarter of 2010 to the 3rd quarter of 2023,and the ratio of reporting ratio(ROR)method and the proportional reporting ratio(PRR)method were used for data mining and analysis.Results A total of 32 728 adverse event reports with lurasidone as the first suspected drug was obtained,with a larger proportion of females(54.26％)and occurring mostly in adults(18 to 59 years).After the screening,326 preferred term(PT)signals were obtained,involving 20 system-organ classifications(injury,poisoning and procedural complications,general disorders and administration site conditions,psychiatric disorders,etc.).Among them,PTs with the higher frequency of occurrence included off label use,feeling abnormal,crying,anxiety,depression,insomnia,etc.PTs with stronger signal strength included activation syndrome,mania,tongue movement disturbance,hypoprolactinaemia,akathisia,etc.Multiple new suspected adverse drug reactions were unearthed,including hypoprolactinaemia,emotional poverty,stiff tongue,etc.Conclusion Lurasidone has a favorable safety profile,and women need to closely monitor prolactin levels when taking this medication.The drug is relatively safe for use in pregnant,puerperal and perinatal women and patients with poor metabolic function.Hypoprolactinaemia and restless leg syndrome are new rare suspected adverse events with lurasidone.

Ankylosing spondylitis (AS) combined with lower cervical fracture is often categorized into unstable fracture, with a high incidence of neurological injury and a high rate of disability and morbidity. As factors such as shoulder occlusion may affect the accuracy of X-ray imaging diagnosis, it is often easily misdiagnosed at the primary diagnosis. Non-operative treatment has complications such as bone nonunion and the possibility of secondary neurological damage, while the timing, access and choice of surgical treatment are still controversial. Currently, there are no clinical practice guidelines for the treatment of AS combined with lower cervical fracture with or without dislocation. To this end, the Spinal Trauma Group of Orthopedics Branch of Chinese Medical Doctor Association organized experts to formulate Clinical guidelines for the treatment of ankylosing spondylitis combined with lower cervical fracture in adults ( version 2024) in accordance with the principles of evidence-based medicine, scientificity and practicality, in which 11 recommendations were put forward in terms of the diagnosis, imaging evaluation, typing and treatment, etc, to provide guidance for the diagnosis and treatment of AS combined with lower cervical fracture.

Objective To explore the difference in efficacy of metoprolol versus ivabradine in the treatment of postural orthostatic tachycardia syndrome(POTS)in the elderly after COVID-19 infection.Methods A total of 110 patients diagnosed with POTS at our department from Decem-ber 1,2022 to January 31,2023 were included.According to their drug regimen,they were divided into metoprolol group(62 patients)and ivabradine group(48 patients).On the 28th day of out-patient follow-up,the resting heart rate,heart rate of 10 min of standing,symptom disappearance rate,hospitalization rate,and mortality rate were compared between the two groups.Results On the 28th day of treatment,the resting heart rate and postural heart rate for 10 min were decreased in both groups when compared with the levels at initial diagnosis(P＜0.01).And there were no significant differences in the two types of heart rate between the two groups on the 28th day(71.0±7.0 vs 72.1±7.0,P=0.401;76.5±7.2 vs 77.4±7.6,P=0.573).No obvious differences were observed between the two groups in symptom disappearance rate,hospitalization rate,or mortality rate(88.7％vs 89.6％,3.2％vs2.1％,0％vs 0％,P＞0.05).Conclusion Metoprolol and ivabradine can effectively treat POTS in the elderly patients after COVID-19 infection.

Objective To explore whether Astragalus polysaccharide can inhibit immune escape of T helper cells 17(Th17)and regulatory T cells(Treg)-mediated tumor cell immune escape in mice with bladder cancer by regulating the transforming growth factor-β1(TGF-β1)/FOXP3/retinoic acid receptor-associated orphan receptor-γT(RORγt)pathway.Methods Human bladder cancer cell line 5637 was injected into the BALB/c male nude mice to establish the model.After successful mold making,the model mice were randomly divided into model group,control group and experimental-L,-M,-H groups,10 mice per group;another 10 normal mice were taken as the blank group.The experimental-L,-M,-H groups were administered with stragalus polysaccharide solutions at doses of 100,200 and 300 mg·kg-1·d-1 by gavage,respectively.The model group and blank group were administered with 0.9％NaCl solution at a dose of 20 mL·kg-1·d-1 by gavage.The control group was administered with cisplatin at a dose of 5 mg·kg-1·d-1 by gavage.Six groups were treated for one month with once a day.After the drug,the tumor suppression was calculated.The cell apoptosis was determined by the TUNEL assay.The counts of Th1 and Treg cells were determined by flow cytometry.The expression levels of TGF-β1,FoxP3 and RORγt in bladder tissues were determined by Western blotting.Results The tumor weight of the experimental-H,the control group and the model group were(0.89±0.12),(0.67±0.09)and(2.09±0.31)g,respectively;the apoptosis indexes were(21.93±2.53)％,(23.91±2.18)％and(4.18±0.39)％,respectively.The contents of Treg cells in experimental-H group,control group,model group and blank group were(3.18±1.15)％,(2.97±0.98)％,(17.23±5.34)％and(2.73±1.04)％,respectively;the contents of Th7 cells were(1.03±0.36)％,(0.92±0.33)％,(6.28±1.96)％and(0.86±0.33)％,respectively;the relative expression levels of TGF-β1 protein were 0.34±0.13,0.33±0.11,0.69±0.10 and 0.32±0.08,respectively;the relative expression levels of FoxP3 protein were 0.21±0.05,0.20±0.06,0.72±0.16 and 0.19±0.06,respectively;the relative expression levels of RORγt protein were 0.34±0.12,0.32±0.12,0.66±0.17 and 0.36±0.09,respectively.Compared with experimental-H and control groups,the above indexes in the model group were statistically significant(all P＜0.05).Conclusion Astragalus polysaccharide can regulate the TGF-β1/FoxP3/RORγt pathway to inhibit Treg and Th7 cells-mediated immune evasion of bladder cancer in mice.