1.Role of noninvasive tests in the prognostication of metabolic dysfunction-associated steatotic liver disease
Yue WANG ; Sherlot Juan SONG ; Yichong JIANG ; Jimmy Che-To LAI ; Grace Lai-Hung WONG ; Vincent Wai-Sun WONG ; Terry Cheuk-Fung YIP
Clinical and Molecular Hepatology 2025;31(Suppl):S51-S75
In managing metabolic dysfunction-associated steatotic liver disease, which affects over 30% of the general population, effective noninvasive biomarkers for assessing disease severity, monitoring disease progression, predicting the development of liver-related complications, and assessing treatment response are crucial. The advantage of simple fibrosis scores lies in their widespread accessibility through routinely performed blood tests and extensive validation in different clinical settings. They have shown reasonable accuracy in diagnosing advanced fibrosis and good performance in excluding the majority of patients with a low risk of liver-related complications. Among patients with elevated serum fibrosis scores, a more specific fibrosis and imaging biomarker has proved useful to accurately identify patients at risk of liver-related complications. Among specific fibrosis blood biomarkers, enhanced liver fibrosis is the most widely utilized and has been approved in the United States as a prognostic biomarker. For imaging biomarkers, the availability of vibration-controlled transient elastography has been largely improved over the past years, enabling the use of liver stiffness measurement (LSM) for accurate assessment of significant and advanced fibrosis, and cirrhosis. Combining LSM with other routinely available blood tests enhances the ability to diagnose at-risk metabolic dysfunction-associated steatohepatitis and predict liver-related complications, some reaching an accuracy comparable to that of liver biopsy. Magnetic resonance imaging-based modalities provide the most accurate quantification of liver fibrosis, though the current utilization is limited to research settings. Expanding their future use in clinical practice depends on factors such as cost and facility availability.
2.Role of noninvasive tests in the prognostication of metabolic dysfunction-associated steatotic liver disease
Yue WANG ; Sherlot Juan SONG ; Yichong JIANG ; Jimmy Che-To LAI ; Grace Lai-Hung WONG ; Vincent Wai-Sun WONG ; Terry Cheuk-Fung YIP
Clinical and Molecular Hepatology 2025;31(Suppl):S51-S75
In managing metabolic dysfunction-associated steatotic liver disease, which affects over 30% of the general population, effective noninvasive biomarkers for assessing disease severity, monitoring disease progression, predicting the development of liver-related complications, and assessing treatment response are crucial. The advantage of simple fibrosis scores lies in their widespread accessibility through routinely performed blood tests and extensive validation in different clinical settings. They have shown reasonable accuracy in diagnosing advanced fibrosis and good performance in excluding the majority of patients with a low risk of liver-related complications. Among patients with elevated serum fibrosis scores, a more specific fibrosis and imaging biomarker has proved useful to accurately identify patients at risk of liver-related complications. Among specific fibrosis blood biomarkers, enhanced liver fibrosis is the most widely utilized and has been approved in the United States as a prognostic biomarker. For imaging biomarkers, the availability of vibration-controlled transient elastography has been largely improved over the past years, enabling the use of liver stiffness measurement (LSM) for accurate assessment of significant and advanced fibrosis, and cirrhosis. Combining LSM with other routinely available blood tests enhances the ability to diagnose at-risk metabolic dysfunction-associated steatohepatitis and predict liver-related complications, some reaching an accuracy comparable to that of liver biopsy. Magnetic resonance imaging-based modalities provide the most accurate quantification of liver fibrosis, though the current utilization is limited to research settings. Expanding their future use in clinical practice depends on factors such as cost and facility availability.
3.Role of noninvasive tests in the prognostication of metabolic dysfunction-associated steatotic liver disease
Yue WANG ; Sherlot Juan SONG ; Yichong JIANG ; Jimmy Che-To LAI ; Grace Lai-Hung WONG ; Vincent Wai-Sun WONG ; Terry Cheuk-Fung YIP
Clinical and Molecular Hepatology 2025;31(Suppl):S51-S75
In managing metabolic dysfunction-associated steatotic liver disease, which affects over 30% of the general population, effective noninvasive biomarkers for assessing disease severity, monitoring disease progression, predicting the development of liver-related complications, and assessing treatment response are crucial. The advantage of simple fibrosis scores lies in their widespread accessibility through routinely performed blood tests and extensive validation in different clinical settings. They have shown reasonable accuracy in diagnosing advanced fibrosis and good performance in excluding the majority of patients with a low risk of liver-related complications. Among patients with elevated serum fibrosis scores, a more specific fibrosis and imaging biomarker has proved useful to accurately identify patients at risk of liver-related complications. Among specific fibrosis blood biomarkers, enhanced liver fibrosis is the most widely utilized and has been approved in the United States as a prognostic biomarker. For imaging biomarkers, the availability of vibration-controlled transient elastography has been largely improved over the past years, enabling the use of liver stiffness measurement (LSM) for accurate assessment of significant and advanced fibrosis, and cirrhosis. Combining LSM with other routinely available blood tests enhances the ability to diagnose at-risk metabolic dysfunction-associated steatohepatitis and predict liver-related complications, some reaching an accuracy comparable to that of liver biopsy. Magnetic resonance imaging-based modalities provide the most accurate quantification of liver fibrosis, though the current utilization is limited to research settings. Expanding their future use in clinical practice depends on factors such as cost and facility availability.
4.Research Progress of Behavioral Intervention in Children with Voice Disorders
Hengxin LIU ; Hua WANG ; Grace HAO ; Yang YANG ; Zijian PANG ; Sherry FU
Journal of Audiology and Speech Pathology 2024;32(2):176-181
This article summarized the general situation,impact and evaluation of voice disorders in children.According to the five models of clinical research in the field of speech therapy and audiology,the research on behav-ioral intervention of voice disorders in children was organized as follows:Model 1 involved studies on treatment se-lection and efficacy prediction.Model 2 focused on efficacy exploration and clinical trial preparation.Model 3 encom-passed studies on clinical implementation and efficacy verification.Model 4 involved comparative studies that explore different treatment methods.Model 5 focused on the analysis of social cost.These models could be used as a refer-ence for scientific research and clinical professionals.
5.Evaluation of a newly developed oral and maxillofacial surgical robotic platform(KD-SR-01)in head and neck surgery:a preclinical trial in porcine models
Ma ZHONGKAI ; Guo ZHIYONG ; Ding ZHANGFAN ; Cao CHANG ; He JIALU ; Tang HEYI ; Hua YUFEI ; Hong JIAWEI ; Shen QIANG ; Grace Paka LUBAMBA ; Wang XIAOYI ; Yang ZHENG ; Zhu GUIQUAN ; Li CHUNJIE
International Journal of Oral Science 2024;16(4):759-766
Traditional open head and neck surgery often leaves permanent scars,significantly affecting appearance.The emergence of surgical robots has introduced a new era for minimally invasive surgery.However,the complex anatomy of the head and neck region,particularly the oral and maxillofacial areas,combined with the high costs associated with established systems such as the da Vinci,has limited the widespread adoption of surgical robots in this field.Recently,surgical robotic platform in China has developed rapidly,exemplified by the promise shown by the KangDuo Surgical Robot(KD-SR).Although the KD-SR has achieved some results comparable to the da Vinci surgical robot in urology and colorectal surgery,its performance in complex head and neck regions remains untested.This study evaluated the feasibility,effectiveness,and safety of the newly developed KD-SR-01,comparing it with standard endoscopic systems in head and neck procedures on porcine models.We performed parotidectomy,submandibular gland resection,and neck dissection,collected baseline characteristics,perioperative data,and specifically assessed cognitive workload using the NASA-TLX.None of the robotic procedures were converted to endoscopic or open surgery.The results showed no significant difference in operation time between the two groups(P=0.126),better intraoperative bleeding control(P=0.001),and a significant reduction in cognitive workload(P<0.001)in the robotic group.In conclusion,the KD-SR-01 is feasible,effective,and safe for head and neck surgery.Further investigation through well-designed clinical trials with long-term follow-up is necessary to establish the full potential of this emerging robotic platform.
6.Evaluation of a newly developed oral and maxillofacial surgical robotic platform(KD-SR-01)in head and neck surgery:a preclinical trial in porcine models
Ma ZHONGKAI ; Guo ZHIYONG ; Ding ZHANGFAN ; Cao CHANG ; He JIALU ; Tang HEYI ; Hua YUFEI ; Hong JIAWEI ; Shen QIANG ; Grace Paka LUBAMBA ; Wang XIAOYI ; Yang ZHENG ; Zhu GUIQUAN ; Li CHUNJIE
International Journal of Oral Science 2024;16(4):759-766
Traditional open head and neck surgery often leaves permanent scars,significantly affecting appearance.The emergence of surgical robots has introduced a new era for minimally invasive surgery.However,the complex anatomy of the head and neck region,particularly the oral and maxillofacial areas,combined with the high costs associated with established systems such as the da Vinci,has limited the widespread adoption of surgical robots in this field.Recently,surgical robotic platform in China has developed rapidly,exemplified by the promise shown by the KangDuo Surgical Robot(KD-SR).Although the KD-SR has achieved some results comparable to the da Vinci surgical robot in urology and colorectal surgery,its performance in complex head and neck regions remains untested.This study evaluated the feasibility,effectiveness,and safety of the newly developed KD-SR-01,comparing it with standard endoscopic systems in head and neck procedures on porcine models.We performed parotidectomy,submandibular gland resection,and neck dissection,collected baseline characteristics,perioperative data,and specifically assessed cognitive workload using the NASA-TLX.None of the robotic procedures were converted to endoscopic or open surgery.The results showed no significant difference in operation time between the two groups(P=0.126),better intraoperative bleeding control(P=0.001),and a significant reduction in cognitive workload(P<0.001)in the robotic group.In conclusion,the KD-SR-01 is feasible,effective,and safe for head and neck surgery.Further investigation through well-designed clinical trials with long-term follow-up is necessary to establish the full potential of this emerging robotic platform.
7.Understanding health literacy from a traditional Chinese medicine perspective.
Zhiyi QIAN ; Grace Y WANG ; Marcus HENNING ; Yan CHEN
Journal of Integrative Medicine 2023;21(3):215-220
Health literacy is critical to improving individual and public health. However, indigenous perceptions of health are largely absent from Western-derived measurements, contributing to disparities in health outcomes between indigenous and non-indigenous populations. China is the country with the world's largest population and only officially introduced the term "health literacy" in 2008. Current measures of health literacy in China are primarily based on Western-derived constructs, which have been shown to have poor comparability to the unique dual medical system in China. Given its significant importance to health management globally, understanding health perceptions from a traditional Chinese medicine perspective is essential. This review explores the concept and core elements of indigenous health literacy, evaluates the existing definitions and measurement tools as applied to the concept, and proposes a new model of traditional Chinese medicine health literacy. Please cite this article as: Qian Z, Wang GY, Henning M, Chen Y. Understanding health literacy from a traditional Chinese medicine perspective. J Integr Med. 2023; 21(3): 215-220.
Medicine, Chinese Traditional
;
Health Literacy
;
China
8.Validation of Filipino version of a questionnaire on work- related asthma among healthcare workers of the Philippine General Hospital: A prospective cross-sectional study
Joel M. Santiaguel ; Mary Grace P. Quilloy-Arellano ; Adele H. Espaldon ; Maria Philina B. Pablo ; Aileen S. David-Wang ; Mithi Kalayaan S. Zamora
Philippine Journal of Internal Medicine 2023;61(3):149-163
Objective:
This study aims to validate a Filipino version of the questionnaire by Delclos et al on occupational risk factors and asthma among the health care workers of the Philippine General Hospital.
Methodology:
Forward and backward translation method for bilinguals was used in this study. The Filipino translation was administered to 110 health care workers selected by stratified random sampling. After 24 hours, the retranslated English version was given to the same respondents. Testing for internal consistency reliability was done by computing for Cronbach's alpha. Construct validity was subsequently determined using the Cramer's V Coefficient.
Results:
The Filipino questionnaire showed good internal consistency reliability, as shown by the overall Cronbach’s alpha of 0.9016, which is comparable to that of the original version by Delclos. Likewise, our Filipino questionnaire showed good construct validity, supported by the Cramer’s V coefficients ranging from 0.2204 (strong relationship) to 0.7843 (very strong relationship).
Conclusion
Overall, the Filipino version of the questionnaire for work-related asthma tested among the health care
workers of Philippine General Hospital showed good reliability and validity. This may now be used as screening tool for occupational asthma among health care workers who are at risk of developing the disease. In addition, this research tool may be utilized to establish the prevalence of occupational asthma in hospitals and later on, aid in the development of a better working environment for the whole health care team.
Health Personnel
;
Surveys and Questionnaires
9.Impact of medical school responses during the COVID-19 pandemic on student satisfaction: a nationwide survey of US medical students
Isaac E. KIM JR. ; Daniel D. KIM ; Juliana E. KIM ; Elliott REBELLO ; David CHUNG ; Parker WOOLLEY ; Daniel LEE ; Brittany A. BORDEN ; Aaron WANG ; Douglas VILLALTA ; Agatha SUTHERLAND ; Sebastian DE ARMAS ; Matthew LIU ; Hannah KIM ; Grace Sora AHN ; Reed GEISLER ; Alexander YANG ; Bowon JOUNG ; John SLATE-ROMANO ; Michal RAJSKI ; Alison E. KIM ; Roxanne VREES ; Kristina MONTEIRO
Korean Journal of Medical Education 2022;34(2):167-174
Purpose:
Medical schools have faced various challenges in preparing their clinical students for the frontlines of a pandemic. This study investigated medical students’ satisfaction with their institutions during the coronavirus disease 2019 (COVID-19) pandemic with the intention of guiding educators in future public health crises.
Methods:
In this cross-sectional study surveying students in clinical rotations, the primary outcome was overall satisfaction regarding medical schools’ responses to the pandemic, and the four secondary outcomes were school communication, exposure to COVID-19, availability of personal protective equipment, and access to COVID-19 testing.
Results:
The survey was distributed to ten medical schools, of which 430 students responded for a response rate of 13.0%. While most students were satisfied (61.9%, n=266) with their schools’ response, more than one in five (21.9%, n=94) were dissatisfied. Among the four secondary outcomes, communication with students was most predictive of overall satisfaction.
Conclusion
In future crises, schools can best improve student satisfaction by prioritizing timely communication.
10.Structures of the portal vertex reveal essential protein-protein interactions for Herpesvirus assembly and maturation.
Nan WANG ; Wenyuan CHEN ; Ling ZHU ; Dongjie ZHU ; Rui FENG ; Jialing WANG ; Bin ZHU ; Xinzheng ZHANG ; Xiaoqing CHEN ; Xianjie LIU ; Runbin YAN ; Dongyao NI ; Grace Guoying ZHOU ; Hongrong LIU ; Zihe RAO ; Xiangxi WANG
Protein & Cell 2020;11(5):366-373


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