Objective:To study the correlation among preoperative serum carbohydrate antigen (CA) 153, CA125 and postoperative recovery, prognosis of patients with breast cancer.Methods:A total of 126 breast cancer patients admitted to our hospital from Jan. 2022 to Jan. 2024 undergoing surgical treatment were chosen as the observation group, and 50 healthy subjects were chosen as the control group during the same period. Serum CA153 and CA125 levels in the two groups were detected. The postoperative recovery of patients in the observation group was analyzed, and the correlation among postoperative recovery indexes and preoperative serum CA153, CA125 was analyzed. Patients were followed up for 6 months after surgery, and were divided into the good prognosis group and the poor prognosis group according to whether there was tumor recurrence or metastasis. Logistic regression was used to analyze the correlation among prognosis, serum CA153, CA125 levels and clinicopathological parameters of patients with breast cancer.Results:The levels of serum CA153 and CA125 in the observation group were significantly higher than those in the control group ( t=22.31, 18.82, P<0.05) ; The first time of anal exhaust, the first time of getting out of bed and the time of hospitalization after breast cancer surgery were (11.26±2.16) h, (23.30±3.54) h and (8.26±2.20) d, respectively; Postoperative recovery indexes were significantly positively correlated with preoperative serum CA153 and CA125 levels ( r=0.33, 0.45, 0.34, 0.41, 0.36, 0.50, P<0.05) ; After 6 months of follow-up, 43 patients had recurrence and metastasis, accounting for 12.20%, which could be divided into good prognosis group ( n=111) and poor prognosis group ( n=15) . Preoperative serum CA153 and CA125 levels in good prognosis group were significantly lower than those in poor prognosis group ( t=3.75, 3.61, P<0.05) ; There were no significant differences in age, menstrual status or pathological type between the good prognosis group and the poor prognosis group ( χ2=0.45, 1.49, 0.34, P>0.05) , but there were significant differences in tumor diameter, TNM stage and lymph node metastasis between the two groups ( χ2=4.38, 5.38, 5.74, P<0.05) ; Logistic regression analysis showed that CA153 ( OR=4.669, 95% CI=1.537-14.187, P<0.05) , CA125 ( OR=2.517, 95% CI=1.622-3.904, P<0.05) , TNM stage ( OR=2.942, 95% CI=1.299-6.661, P<0.05) and lymph node metastasis ( OR=3.622, 95% CI=1.242-10.561, P<0.05) were risk factors for postoperative recurrence and metastasis of breast cancer ( P<0.05) . Conclusions:Preoperative serum CA153 and CA125 levels in patients with breast cancer are related to postoperative recovery and prognosis.

Objective:To study the correlation among preoperative serum carbohydrate antigen (CA) 153, CA125 and postoperative recovery, prognosis of patients with breast cancer.Methods:A total of 126 breast cancer patients admitted to our hospital from Jan. 2022 to Jan. 2024 undergoing surgical treatment were chosen as the observation group, and 50 healthy subjects were chosen as the control group during the same period. Serum CA153 and CA125 levels in the two groups were detected. The postoperative recovery of patients in the observation group was analyzed, and the correlation among postoperative recovery indexes and preoperative serum CA153, CA125 was analyzed. Patients were followed up for 6 months after surgery, and were divided into the good prognosis group and the poor prognosis group according to whether there was tumor recurrence or metastasis. Logistic regression was used to analyze the correlation among prognosis, serum CA153, CA125 levels and clinicopathological parameters of patients with breast cancer.Results:The levels of serum CA153 and CA125 in the observation group were significantly higher than those in the control group ( t=22.31, 18.82, P<0.05) ; The first time of anal exhaust, the first time of getting out of bed and the time of hospitalization after breast cancer surgery were (11.26±2.16) h, (23.30±3.54) h and (8.26±2.20) d, respectively; Postoperative recovery indexes were significantly positively correlated with preoperative serum CA153 and CA125 levels ( r=0.33, 0.45, 0.34, 0.41, 0.36, 0.50, P<0.05) ; After 6 months of follow-up, 43 patients had recurrence and metastasis, accounting for 12.20%, which could be divided into good prognosis group ( n=111) and poor prognosis group ( n=15) . Preoperative serum CA153 and CA125 levels in good prognosis group were significantly lower than those in poor prognosis group ( t=3.75, 3.61, P<0.05) ; There were no significant differences in age, menstrual status or pathological type between the good prognosis group and the poor prognosis group ( χ2=0.45, 1.49, 0.34, P>0.05) , but there were significant differences in tumor diameter, TNM stage and lymph node metastasis between the two groups ( χ2=4.38, 5.38, 5.74, P<0.05) ; Logistic regression analysis showed that CA153 ( OR=4.669, 95% CI=1.537-14.187, P<0.05) , CA125 ( OR=2.517, 95% CI=1.622-3.904, P<0.05) , TNM stage ( OR=2.942, 95% CI=1.299-6.661, P<0.05) and lymph node metastasis ( OR=3.622, 95% CI=1.242-10.561, P<0.05) were risk factors for postoperative recurrence and metastasis of breast cancer ( P<0.05) . Conclusions:Preoperative serum CA153 and CA125 levels in patients with breast cancer are related to postoperative recovery and prognosis.

Objective:To evaluate the feasibility of the gasless transoral endoscopic thyroidectomy using an innovative space maintaining method.Methods:From Dec. 2018 to Apr. 2019, patients from Anhui Tumor Hospital treated with gasless transoral endoscopic thyroidectomy were retrospectively analyzed. Index such as intraoperative blood loss, operative time, postoperative hospital stay, and complications were recorded.Results:A total of 24 patients were included into this analysis. All operations were successfully completed. The mean blood loss was (41.3±26.4) ml, operation time was (191.8±40.8) min, postoperative hospital stay was (6.3±1.0) d. Nobody had drinking cough, recurrent laryngeal nerve palsy, massive bleeding, hypoparathyroidism or infection with use of preventive antibacteria. Transient lower jaw numbness was found in 8 patients and almost recovered within one month.Conclusions:Gasless transoral endoscopic thyroidectomy with the suspension device seems to be feasible and safe. Further study is needed to verify its validity.

Objective To investigate the clinical significance of the carbon nanoparticles (CN) in prophylactic central compartment lymph node dissection (PCCND) in treatment of clinically node-negative (cN0) papillary thyroid carcinoma.Methods A total of 102 cN0 patients in our department from Dec.2016 to Jun.2017 were enrolled in our study and randomly allocated to the control group (n=51) and the CN group (n=51).All the patients have received (near) total unilateral lobectomy or bilateral thyroidectomy plus the affected side PCCND.The baseline characteristics,lymph node-related indices (including number of total dissected lymph nodes and metastatic lymph nodes at central area) and postoperative complication indices were collected and compared between the 2 groups.Results The differences of baseline characteristics between CN group and the control group were not significant (all P＞0.05).The total number of dissected lymph nodes was 573 in CN group and 334 in the control group.The average lymph nodes in each patient was 11.2±5.46 in CN group,which was higher than 6.5±4.3 of the control group (P＜0.001).The average count of positive lymph nodes was higher in CN group than in the control group (2.0±3.3 vs 0.8±1.5) (P＜0.05).Transient hypocalcaemia happened to 2 patients in CN group and 9 patients in the control group (P=0.025).Conclusions CN can increase the number of lymph nodes in central neck dissection and the rate of metastatic lymph nodes resection.It can decrease the risk of transient parathyroid injury.CN is clinically valuable in treatment of cN0 papillary thyroid cancer undergoing PCCND.