Objective To discuss the correlation between free prostate specific antigen(fPSA),serum ferritin(SF),blood uric acid(SUA)levels and Gleason grading in patients with prostate cancer(PCa).Methods The clinical data of 61 patients with prostate biopsy treated in 411 Hospital of Shanghai University from January to December of 2023 were retrospectively analyzed.According to the results of puncture,the patients were divided into benign prostatic hyperpla-sia(BPH)group(31 cases)and PCa group(30 cases).The levels of fPSA,SF and SUA in patients and Gleason grade in biopsy cases were analyzed.The correlation between fPSA,SF and SUA levels and Gleason grade was analyzed by the method of Spearman.And the diagnostic efficacy of fPSA,SF and SUA levels on PCa was analyzed by receiver operating characteristic curve(ROC).Results The levels of fPSA,SF and SUA in PCa group were significantly higher than those in BPH group(P＜0.05).There were statistically significant differences in levels of fPSA SF and SUA in PCA patients with different Gleason grades(P＜0.05).With the specificity reaching 96.08％and sensitivity reaching 94.35％,the ar-ea under the curve(AUC)of the combined fPSA,SF and SUA levels in the diagnosis of PCa was 0.982,which was higher than that of the single fPSA,SF and SUA levels(P＜0.05).SF and SUA levels in PCa patients were positively correlated with Gleason grade(P＜0.05),while fPSA levels were not correlated with Gleason grade(P＞0.05).Conclusion The levels of SF and SUA in PCa patients are positively correlated with Gleason grade,which can be used as an important index to predict Gleason grade in PCa patients.

Objective To discuss the correlation between free prostate specific antigen(fPSA),serum ferritin(SF),blood uric acid(SUA)levels and Gleason grading in patients with prostate cancer(PCa).Methods The clinical data of 61 patients with prostate biopsy treated in 411 Hospital of Shanghai University from January to December of 2023 were retrospectively analyzed.According to the results of puncture,the patients were divided into benign prostatic hyperpla-sia(BPH)group(31 cases)and PCa group(30 cases).The levels of fPSA,SF and SUA in patients and Gleason grade in biopsy cases were analyzed.The correlation between fPSA,SF and SUA levels and Gleason grade was analyzed by the method of Spearman.And the diagnostic efficacy of fPSA,SF and SUA levels on PCa was analyzed by receiver operating characteristic curve(ROC).Results The levels of fPSA,SF and SUA in PCa group were significantly higher than those in BPH group(P＜0.05).There were statistically significant differences in levels of fPSA SF and SUA in PCA patients with different Gleason grades(P＜0.05).With the specificity reaching 96.08％and sensitivity reaching 94.35％,the ar-ea under the curve(AUC)of the combined fPSA,SF and SUA levels in the diagnosis of PCa was 0.982,which was higher than that of the single fPSA,SF and SUA levels(P＜0.05).SF and SUA levels in PCa patients were positively correlated with Gleason grade(P＜0.05),while fPSA levels were not correlated with Gleason grade(P＞0.05).Conclusion The levels of SF and SUA in PCa patients are positively correlated with Gleason grade,which can be used as an important index to predict Gleason grade in PCa patients.

Objective To investigate the mechanism of bladder hydrodistension and combined with hyperbaric oxygen (HBO) in the treatment of interstitial cystitis (IC) and evaluate its therapeutic efficacy.Methods Twenty-three confirmed IC patients were treated with bladder hydrodistension plus HBO therapy.Results Two IC patients abandoned the therapy,due to intolerance to HBO pressure,the remaining 21 patients all completed the prescheduled therapy.As compared with those before therapy,statistical significance could be noticed in the scores of interstitial cystitis symptom index (ICSI),maximum urine volume,visual analogue scale (VAS),24-hour urination and quality of life (QOL),following 3 and 6 months of treatment respectively.Interestingly,the therapeutic efficacy after 3 months of treatment was more prominent(P ＜ 0.05) Conclusions Bladder hydrodistentioa combined with HBO therapy was a safe and effective treatment method for IC.However,its long term effect remained to be seen.

Objective To investigate the mechanism of bladder hydrodistension and combined with hyperbaric oxygen (HBO) in the treatment of interstitial cystitis (IC) and evaluate its therapeutic efficacy.Methods Twenty-three confirmed IC patients were treated with bladder hydrodistension plus HBO therapy.Results Two IC patients abandoned the therapy,due to intolerance to HBO pressure,the remaining 21 patients all completed the prescheduled therapy.As compared with those before therapy,statistical significance could be noticed in the scores of interstitial cystitis symptom index (ICSI),maximum urine volume,visual analogue scale (VAS),24-hour urination and quality of life (QOL),following 3 and 6 months of treatment respectively.Interestingly,the therapeutic efficacy after 3 months of treatment was more prominent(P ＜ 0.05) Conclusions Bladder hydrodistentioa combined with HBO therapy was a safe and effective treatment method for IC.However,its long term effect remained to be seen.