1.Exploration of Deng Gaopi's Diagnostic and Therapeutic Approach for Cesarean Scar Pregnancy
Genping ZENG ; Peiyin LI ; Xijing LU ; Lei ZENG ; Gaopi DENG
Journal of Guangzhou University of Traditional Chinese Medicine 2025;42(9):2314-2320
Cesarean scar pregnancy(CSP)is a special type of ectopic pregnancy(EP)that poses a serious threat to women's reproductive health.Professor Deng Gaopi,a renowned traditional Chinese medicine(TCM)expert of Guangdong Province,has extensive experience in the diagnosis and treatment of EP.He believes that the key pathogenesis of EP is due to the obstruction of blood stasis in the lower abdomen and the disharmony of chong-ren meridians,with the core pathogenic factor of blood stasis and with the disease location in the uterus.As a special type of EP,CSP shares the similar pathogenesis to that of EP.The occurrence of CSP is attributed to the obstruction of qi,blood and body fluids induced by insufficient healthy qi after cesarean delivery,and then phlegm-turbidity and blood stasis congealing in the chong-ren meridians and uterus,resulting in blood vessel stasis and collateral damage,which causes the fertilized egg to implant in the scar.The treatment of CSP should start from the pathogenesis of phlegm blended with blood stasis and stasis developing into masses,with the main therapeutic methods of supplementing qi,activating blood,resolving stasis,and removing masses.The foundational prescriptions include Huayu Xiaozheng Granules(composed of Salviae Miltiorrhizae Radix et Rhizoma,Paeoniae Radix Rubra,Persicae Semen,Achyranthis Bidentatae Radix,Moutan Cortex,Trichosanthis Radix,Arnebiae Radix,etc.)and Lichong Decoction(composed of Astragali Radix,Codonopsis Radix,Atractylodis Macrocephalae Rhizoma,Dioscoreae Rhizoma,Sparganii Rhizoma,Curcumae Rhizoma,Anemarrhenae Rhizoma,Trichosanthis Radix,Galli Gigerii Endothelium Corneum,etc.).Based on the relationship between qi and blood,i.e.,the enrichment of qi promoting the generation of blood,and the movement of qi promoting the removal of stasis,he emphasizes the importance of treatment based on qi-blood differentiation.Additionally,he is skillful in using genuine Lingnan medicinal herbs such as Microctis Folium and Guangdong Pheretima based on regional characteristics and following the principle of individualization.In terms of preventing CSP and its complications,Professor Deng advocates for strengthening the spleen and promoting granulation to fundamentally eliminate to the endometrial damage caused by cesarean section.For complications caused by damp-heat accumulation in the lower energizer which results from the obstruction of blood stasis in the uterus,heat-clearing,dampness-removing,and blood-activating actions should be enhanced in the clinical prescriptions for treatment.
2.Promoting Reform of Talent Evaluation Based on China Clinical Cases Library of Traditional Chinese Medicine
Kaige ZHANG ; Yong ZHU ; Jisheng WANG ; Liangzhen YOU ; Weijun HUANG ; Jie YANG ; Candong LI ; Genping LEI ; Chuan ZHENG ; Shuzhen GUO ; Longtao LIU ; Zhining TIAN ; Xinping QIU ; Wenli SU ; Zuo LI ; Wei YAN ; Hongcai SHANG ; Xiaoxiao ZHANG
Chinese Journal of Experimental Traditional Medical Formulae 2024;30(17):220-226
Talents are the main force for the development of traditional Chinese medicine(TCM), and the construction of TCM talents and the reformation of talent evaluation system are essential to promote the inheritance and innovation of TCM. At present, we are still exploring and developing in the fields of the formulation, implementation and evaluation indicators of TCM talent evaluation system. However, there are shortcomings and difficulties. For instance, insufficient stratification in the evaluation, excessive emphasis on the quantity of achievements, neglecting the quality of the achievements and the actual contribution, imperfect assessment indicators, and the weak characteristics of TCM. Therefore, national ministries and commissions have jointly issued a document requesting to break the four only and set a new standard, in order to promote the construction of a scientific and technological talent evaluation system oriented by innovation value, ability and contribution. For the evaluation of TCM clinical talents, China Association for Science and Technology commissioned China Association of Chinese Medicine to build the China Clinical Cases Library of TCM(CCCL-TCM), which aims at collecting the most authoritative and representative TCM clinical cases and exploring the advantages of applying clinical cases as masterpiece of achievement in TCM clinical talents evaluation. CCCL-TCM can promote the construction of a talent evaluation system that is more in line with the development characteristics of TCM industry, and to carry out relevant pilot in TCM colleges and institutions across the country in order to promote the reformation of TCM talent evaluation system.
3.Prevention and Treatment of Diabetic Kidney Disease with Traditional Chinese Medicine Based on Diabetic Tubulopathy
Na LI ; Genping LEI ; Ting WANG ; Sheng DONG
World Science and Technology-Modernization of Traditional Chinese Medicine 2023;25(7):2321-2326
Diabetic kidney disease(DKD)is one of the common chronic complications of diabetes mellitus(DM),the primary cause of chronic kidney disease(CKD),including end-stage renal disease(ESRD),and an important risk factor for early death in diabetic patients.As an important starting point of DKD,diabetic tubulopathy(DT)is important for the early prevention and treatment of DKD.It is found that traditional Chinese medicine can effectively delay the course of DKD through the active prevention and treatment of DT,and achieve early prevention,early treatment and good prognosis.The mechanism is mainly to improve and protect the damaged renal tubules in patients in various periods through different targets and pathways,so as to reduce kidney injury,improve the clinical symptoms of patients and delay the course of the disease.This paper reviews the mechanism of renal tubular injury in diabetic kidney disease and the progress of traditional Chinese medicine in the prevention and treatment of diabetic kidney disease based on diabetic tubulopathy in recent years.
4.Discussion on the Related Problems of"Body Pain is Like Being Punished with A Rod"in Synopsis of the Golden Chamber
Dong YANG ; Genping LEI ; Yu MA
Journal of Zhejiang Chinese Medical University 2023;47(12):1479-1484
[Objective]To analyze the meaning of"body pain is like being punished with a rod"in Synopsis of the Golden Chamber·Yin Yang Pestilences,so as to better understand the meaning of Zhongjing.[Methods]By using the research method of combining the handed-down literature with the textual research of unearthed cultural relics,combining with the perspective of character and history,and there is one proved case attached.[Results]"Body pain is like being punished with a rod"is a vivid expression that people describe their personal experience."Rod"can be understood as"anything that can be held is called a rod"."Being punished with a rod"is divided into three cases including skin is swollen and bruised;damage occurs;dead by being punished.Pain may be caused by trauma(skin and muscle)or internal injury(viscera injury).Shengma Biejia Decoction is mainly used to detoxify and disperse evil,promote blood circulation,and give consideration to both Qi and blood.[Conclusion]In the era of Zhongjing,"body pain is like being punished with a rod"has a certain degree of differentiation,which is reflected in the differentiation of the way of applying the rod and the painful feeling.This paper discusses the concept of"body pain is like being punished with a rod"by combining literature and cultural relics research,so that readers can intuitively understand the meaning of Zhongjing in the social background at that time,and also provides a new way to learn Synopsis of the Golden Chamber.
5.Traditional Chinese Medicine Intervention in Membranous Nephropathy Based on Podocyte Injury: A Review
Xin LI ; Genping LEI ; Zhe FENG ; Ting WANG ; Sheng DONG
Chinese Journal of Experimental Traditional Medical Formulae 2023;29(12):257-264
Membranous nephropathy, an autoimmune kidney disease with glomerular podocyte injury as the core mechanism, is a common pathological type of adult nephrotic syndrome and has become the main cause of end-stage renal disease in China. Podocytes are terminally differentiated cells that play an important role in maintaining the structural and functional stability of glomeruli and are molecular barriers for protein filtration. Glomerular filtration membrane injury induced by podocyte injury is an important cause of massive proteinuria. Persistent or aggravated proteinuria may prolong the course of membranous nephropathy. It is believed that podocyte destruction in membranous nephropathy is mainly related to oxidative stress, autophagy dysregulation, abnormal expression of podocyte marker proteins, chronic inflammation, epithelial-mesenchymal cell transdifferentiation, and so on. At present, western medicine mostly uses immunosuppressants and hormones for treatment according to its pathological stage, but there are certain adverse reactions. Traditional Chinese medicine (TCM) has made some achievements in the prevention and treatment of membranous nephropathy. In recent years, studies have found that many Chinese medicines can affect the occurrence and development of membranous nephropathy in different links by acting on multiple targets in the human body, with manifest advantages. This paper overviewed the podocyte injury mechanism in membranous nephropathy and summarized the treatment of membranous nephropathy with Chinese medicine monomers, compounds, and Chinese patent medicines in intervening related target pathways, aiming to provide a basis for the clinical treatment, basic research, and targeted drug development of TCM against membranous nephropathy.

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