OBJECTIVE:To provide basis for the further development of health education about rational drug use. METH-ODS:1 000 permanent residents in 4 urban and rural communities of Chongqing were investigated and collected by random sam-ple,self-designed assessment questionnaires about knowledge-behavior-attitude level of rational antibiotics use were used before and after intervention of health education for essessing of the effects. RESULTS:Totally 2 000 questionnaires were sent out,and 2 000 were effectively received with effective rate of 100%. After intervention,the awareness rate of surveyed residents about“antibi-otics are not anti-inflammatory drugs”“in order to avoiding the infection in daily life,antibiotics can not be used frequently and preventively”and other related knowledge was significantly improved(P<0.05);correct rate of surveyed residents about“the use of antibiotics has its special rules,so it should be cautious to follow the guidance of physicians and can not be used freely”and oth-er related attitude was significantly improved(P<0.05);incidence of surveyed residents about“if discomfort,will you self-seek an-tibiotics(such as purchasing/finding donated/finding previous drugs left in family)”and other related misbehaviors was significantly reduced(P<0.05). The average scores of knowledge,attitude and behavior scores and total scores were significantly higher than be-fore(P<0.05). CONCLUSIONS:It is quite necessary to develop health education intervention of rational antibiotics use in commu-nity residents. Targeted health education intervention has significant effect on improving the knowledge-behavior-attitude level of ra-tional antibiotics use in community residents,and it is worthy of further promotion.