The typical regions have established a coordinated chronic disease management organization system,promoted the coordinated management of health care,medical,and medicine systems,optimized the chronic disease service process,and empowered the grassroots through information technology construction.It has achieved different degrees of results in controlling the condition of patients,reducing the hospitalization rate and the level of medical expenses of patients with chronic diseases,and saving medical insurance funds.

Hospitals without disciplines have no performance performance,the focus of performance reform lies in mechanism transformation.Hospital performance management and discipline construction are interdependent relationships.Performance management provides guidance and motivation for the process of discipline construction,the construction of disciplines provides a value basis for the business connotation of performance management.Guiding discipline construction by clarifying the disease efficacy system.Clarify discipline construction by refining the technical system.Quantify discipline construction by organizing departmental projects.Transform financial and personnel performance assessment into technical value management.The conjugate mechanism can trigger and drive the deployment,support,and fulfillment of business.Performance management plans are only effective when they are publicly available.Only solutions that comply with business logic can be made public.By mining valuable data,we tap into potential business value.

Objective To investigate the expression of prolyl 4-hydroxylase β-polypeptide(P4HB)in glioblastoma multiforme(GBM)and its impact on clinical prognosis,as well as on the proliferation and migration of U87 cells.Methods(1)According to the Cancer Genome Atlas(TCGA)database,GTEx database and GEPIA2 database,the difference expression of P4HB in GBM and normal brain tissues were analyzed by R software.(2)A total of 52 patients with GBM who underwent surgical treatment from February 2017 to December 2019 were collected from Department of Neurosurgery,the Second People's Hospital of Guiyang.The normal brain tissues of 10 patients were selected as controls.Immunohistochemical method was used to detect the expression level of P4HB in tumor tissues and normal tissues.The Kaplan-Meier method with the log-rank test was employed for survival analysis.Receiver operating characteristic(ROC)curve was used to analyze the predictive valuable of P4HB expression in survival rate of GBM.Univariate and multivariate Cox regression analysis were used to identify the expression of P4HB and related clinicopathological factors affecting the survival and prognosis of the patients.(3)Human GBM U87 cells were randomly assigned into three groups:control group,NC-siRNA group and P4HB-siRNA group.P4HB expression was interfered with by the transfection of siRNA in P4HB-siRNA group.Real-time quantitative polymerase chain reaction(qRT-PCR)was used to detect the content of P4HB mRNA in U87 cells.Cell counting kit-8(CCK-8)and immunofluorescence assay were used to analyze the effects of P4HB on the proliferation of U87 cells.Scratch test was used to analyze the effects of P4HB on cell migration.Results The expression of P4HB was significantly upregulated in GBM tissues compared with normal brain tissues(P<0.05).The γδ T cells(r=-0.227)and follicular helper T cells(r=-0.226)were negatively correlated with the expression of P4HB,while natural killer cell(r=0.417),macrophages(r=0.374),neutrophils(r=0.344),and immature dendritic cells(r=0.263)were positively correlated with the expression of P4HB.Kaplan-Meier survival analysis showed that the progression-free survival and disease-specific survival of GBM patients with high P4HB expression were significantly lower than those with low expression(P<0.05).ROC curve showed that the area under the curve(AUC)of P4HB in predicting overall survival rate of GBM patients was 0.982,and 1-year,3-year,and 5-year survival was 0.655,0.724,0.861,respectively.The immunohistochemistry results suggested that P4HB protein was significantly highly expressed in GBM tumors.Survival analysis indicated that high expression of P4HB was associated with bad prognosis in GBM patients(P<0.05).Multivariate Cox regression analysis indicated that high expression of P4HB and TERT promoter mutations were the independent prognostic risk factors for GBM(P<0.05).Compared with control group and NC-siRNA group,the expression levels of P4HB were decreased significantly after transfected with siRNA in U87 cells of P4HB-siRNA group(P<0.01),and the proliferation ability and the wound healing rate were decreased significantly in P4HB-siRNA group(P<0.001).Conclusions P4HB is significantly highly expressed in GBM,which indicates that the prognosis of patients is poor.Knockout of P4HB could inhibit cellular proliferation and migration of GBM U87 cells.P4HB may be used as the relevant predictive marker and potential therapeutic target in GBM.

Background and objective Isoliquiritigenin(ISL)is an important pharmacological constituent of Glycyrrhiza glabra,which possesses a range of physiological and pharmacological activities,as well as significant antitumor ac-tivity,and can be used as a potential drug for targeted cancer therapy.LINC01503 is an oncogene,which has been closely asso-ciated with the malignant biological processes of many cancers.The aim of this study was to investigate the effects of ISL on the proliferation,apoptosis,invasion and migration oflung squamous carcinoma cells by regulating LINC01503.Methods Plasma was collected from lung squamous carcinoma patients and healthy individuals treated at Tangshan People's Hospital from Janu-ary 2021 to December 2022.The expression of LINC01503 in lung squamous carcinoma plasma,tissues and cells was detected by real-time quantitative fluorescence polymerase chain reaction(qRT-PCR).Lung squamous carcinoma cells were treated with different concentrations of ISL for 24 h,and LINC01503 expression was detected by qRT-PCR.The cells were treated in groups:si-NC group,si-LINC01503 group,DMSO(0.1％dimethyl sulfone)group,ISL group,pc DNA3.1(+)-NC group,pc DNA3.1(+)-LINC01503 group,ISL+pc DNA3.1(+)-NC group and ISL+pc DNA3.1(+)-LINC01503 groups.CCK-8 assay,clone formation assay,flow cytometry,Transwell assay and scratch assay were used to explore the effect of LINC01503 on the functional phenotype of lung squamous carcinoma cells.Results Fluorescence in situ hybridization results showed that the average fluorescence intensity of LINC01503 in tissue microarrays of lung squamous carcinoma patients was higher than that in paracancerous tissues(P＜0.05).The expression of LINC01503 in the plasma of patients with lung squamous carcinoma was higher than that in the plasma of healthy individuals(P＜0.05).Knockdown of LINC01503 inhibited the proliferation,invasion and migration of lung squamous carcinoma cells and promoted apoptosis(P＜0.05).ISL inhibited the proliferation,invasion,migration and promoted apoptosis of lung squamous carcinoma cells(P＜0.05).Overexpression of LINC01503 followed by intervention with ISL reversed the promotional effect of overexpression of LINC01503 on the proliferation,invasion and migration of lung squamous carcinoma cells as well as the inhibitory effect on apoptosis(P＜0.05).Conclusion LINC01503 was highly expressed in lung squamous carcinoma,and LINC01503 could promote the proliferation,invasion and migra-tion of lung squamous carcinoma cells and inhibit the apoptosis,ISL could inhibit the proliferation,invasion and migration of lung squamous carcinoma cells and promote apoptosis of lung squamous carcinoma cells by regulating the expression of LINC01503.

Synergistic development and governance among medical services,medical insurance and medicines are crucial for achieving high-quality healthcare and successful healthcare system reform.It systematically analyzes and summarizes Dongtai City's practice on synergistic development and governance among medical services,medical insurance and medicines,highlighted by the reform experiences and measures of the closed-loop system,including strategic design(navigator),leadership for organizing(engine),integration of resources(fuel tank),coordinating instruments(lubricant),and evaluation and feedback(barometer),which are refined into the SLICE model for synergistic development and governance of the"three medical professions".It also proposes to stimulate synergistic governance on healthcare through reform and innovation,fully leveraging the leading role of Party committees and governments at all levels and establishing a cross-departmental deliberative and coordination mechanism for synergistic healthcare governance.It aims to engage diverse stakeholders in synergistic governance and strengthen systematic synergistic governance measures to ensure that the synergistic development of the"three medical professions"and governance reforms are on a steady course.

Synergistic development and governance among medical services,medical insurance and medicines are crucial for achieving high-quality healthcare and successful healthcare system reform.It systematically analyzes and summarizes Dongtai City's practice on synergistic development and governance among medical services,medical insurance and medicines,highlighted by the reform experiences and measures of the closed-loop system,including strategic design(navigator),leadership for organizing(engine),integration of resources(fuel tank),coordinating instruments(lubricant),and evaluation and feedback(barometer),which are refined into the SLICE model for synergistic development and governance of the"three medical professions".It also proposes to stimulate synergistic governance on healthcare through reform and innovation,fully leveraging the leading role of Party committees and governments at all levels and establishing a cross-departmental deliberative and coordination mechanism for synergistic healthcare governance.It aims to engage diverse stakeholders in synergistic governance and strengthen systematic synergistic governance measures to ensure that the synergistic development of the"three medical professions"and governance reforms are on a steady course.

Synergistic development and governance among medical services,medical insurance and medicines are crucial for achieving high-quality healthcare and successful healthcare system reform.It systematically analyzes and summarizes Dongtai City's practice on synergistic development and governance among medical services,medical insurance and medicines,highlighted by the reform experiences and measures of the closed-loop system,including strategic design(navigator),leadership for organizing(engine),integration of resources(fuel tank),coordinating instruments(lubricant),and evaluation and feedback(barometer),which are refined into the SLICE model for synergistic development and governance of the"three medical professions".It also proposes to stimulate synergistic governance on healthcare through reform and innovation,fully leveraging the leading role of Party committees and governments at all levels and establishing a cross-departmental deliberative and coordination mechanism for synergistic healthcare governance.It aims to engage diverse stakeholders in synergistic governance and strengthen systematic synergistic governance measures to ensure that the synergistic development of the"three medical professions"and governance reforms are on a steady course.

Synergistic development and governance among medical services,medical insurance and medicines are crucial for achieving high-quality healthcare and successful healthcare system reform.It systematically analyzes and summarizes Dongtai City's practice on synergistic development and governance among medical services,medical insurance and medicines,highlighted by the reform experiences and measures of the closed-loop system,including strategic design(navigator),leadership for organizing(engine),integration of resources(fuel tank),coordinating instruments(lubricant),and evaluation and feedback(barometer),which are refined into the SLICE model for synergistic development and governance of the"three medical professions".It also proposes to stimulate synergistic governance on healthcare through reform and innovation,fully leveraging the leading role of Party committees and governments at all levels and establishing a cross-departmental deliberative and coordination mechanism for synergistic healthcare governance.It aims to engage diverse stakeholders in synergistic governance and strengthen systematic synergistic governance measures to ensure that the synergistic development of the"three medical professions"and governance reforms are on a steady course.

Synergistic development and governance among medical services,medical insurance and medicines are crucial for achieving high-quality healthcare and successful healthcare system reform.It systematically analyzes and summarizes Dongtai City's practice on synergistic development and governance among medical services,medical insurance and medicines,highlighted by the reform experiences and measures of the closed-loop system,including strategic design(navigator),leadership for organizing(engine),integration of resources(fuel tank),coordinating instruments(lubricant),and evaluation and feedback(barometer),which are refined into the SLICE model for synergistic development and governance of the"three medical professions".It also proposes to stimulate synergistic governance on healthcare through reform and innovation,fully leveraging the leading role of Party committees and governments at all levels and establishing a cross-departmental deliberative and coordination mechanism for synergistic healthcare governance.It aims to engage diverse stakeholders in synergistic governance and strengthen systematic synergistic governance measures to ensure that the synergistic development of the"three medical professions"and governance reforms are on a steady course.

Synergistic development and governance among medical services,medical insurance and medicines are crucial for achieving high-quality healthcare and successful healthcare system reform.It systematically analyzes and summarizes Dongtai City's practice on synergistic development and governance among medical services,medical insurance and medicines,highlighted by the reform experiences and measures of the closed-loop system,including strategic design(navigator),leadership for organizing(engine),integration of resources(fuel tank),coordinating instruments(lubricant),and evaluation and feedback(barometer),which are refined into the SLICE model for synergistic development and governance of the"three medical professions".It also proposes to stimulate synergistic governance on healthcare through reform and innovation,fully leveraging the leading role of Party committees and governments at all levels and establishing a cross-departmental deliberative and coordination mechanism for synergistic healthcare governance.It aims to engage diverse stakeholders in synergistic governance and strengthen systematic synergistic governance measures to ensure that the synergistic development of the"three medical professions"and governance reforms are on a steady course.