Hypertension is one of the important causes of premature death worldwide,and the prevention and treatment of hypertension is of great significance in reducing the incidence and mortality rate of cardiovascular disease.Antihypertensive drugs and food homologous traditional Chinese medicine have the advantages of easy access,high safety,and minimal side effects.Based on the list of 101 traditional Chinese medicinal materials that are both medicinal and food substances released by the National Health Commission,a search was conducted on 101 Chinese medicinal materials related to hypertension using the China National Knowledge Infrastructure(CNKI).The screening criteria are single drug,extract,or monomer therapy for hypertension,and the number of literature is≥2,resulting in 14 medicinal and food homologous traditional Chinese medicines with antihypertensive effects.Search for 14 Chinese medicine names and hypertension keywords on PubMed,Web of Science,and Google Scholar to collect reports on the treatment of hypertension with medicinal and food homologous traditional Chinese medicine.Based on the search results of China National Knowledge Infrastructure,summarize their classification,drug properties,efficacy,antihypertensive effects,and mechanism of action,in order to provide inspiration for new prescriptions,drug development,and functional foods for treating hypertension.Most of the antihypertensive traditional Chinese medicines with the same origin as medicine and food belong to the categories of clearing heat and tonifying deficiency;Most drugs have a sweet and spicy taste,which belongs to the liver,spleen,and kidney meridians.The efficacy is mostly to clear the liver and brighten the eyes,tonify the liver and kidneys,promote qi circulation,dispel blood stasis,and disperse nodules.It mainly inhibits ACE activity;Reduce REN and AngⅡ levels;Upregulate SOD levels and reduce MDA expression;Improve the expression level of NO/NOS;Enhance antioxidant effects;Improve endothelial function;Relieve inflammatory reactions;Various methods such as reducing target organ damage can play a role in treating hypertension.

Hypertension is one of the important causes of premature death worldwide,and the prevention and treatment of hypertension is of great significance in reducing the incidence and mortality rate of cardiovascular disease.Antihypertensive drugs and food homologous traditional Chinese medicine have the advantages of easy access,high safety,and minimal side effects.Based on the list of 101 traditional Chinese medicinal materials that are both medicinal and food substances released by the National Health Commission,a search was conducted on 101 Chinese medicinal materials related to hypertension using the China National Knowledge Infrastructure(CNKI).The screening criteria are single drug,extract,or monomer therapy for hypertension,and the number of literature is≥2,resulting in 14 medicinal and food homologous traditional Chinese medicines with antihypertensive effects.Search for 14 Chinese medicine names and hypertension keywords on PubMed,Web of Science,and Google Scholar to collect reports on the treatment of hypertension with medicinal and food homologous traditional Chinese medicine.Based on the search results of China National Knowledge Infrastructure,summarize their classification,drug properties,efficacy,antihypertensive effects,and mechanism of action,in order to provide inspiration for new prescriptions,drug development,and functional foods for treating hypertension.Most of the antihypertensive traditional Chinese medicines with the same origin as medicine and food belong to the categories of clearing heat and tonifying deficiency;Most drugs have a sweet and spicy taste,which belongs to the liver,spleen,and kidney meridians.The efficacy is mostly to clear the liver and brighten the eyes,tonify the liver and kidneys,promote qi circulation,dispel blood stasis,and disperse nodules.It mainly inhibits ACE activity;Reduce REN and AngⅡ levels;Upregulate SOD levels and reduce MDA expression;Improve the expression level of NO/NOS;Enhance antioxidant effects;Improve endothelial function;Relieve inflammatory reactions;Various methods such as reducing target organ damage can play a role in treating hypertension.

Objective: To investigate the serum levels and clinical significances of microRNA-205 (miR-205) and microRNA-221 (miR-221) in patients with colon cancer. Methods: A total of 172 patients with colon cancer (colon cancer group), 130 patients with benign diseases of colon (benign lesion group) and 70 healthy persons (control group) admitted to Central Hospital of Western Hainan from January 2016 to December 2018 were selected. The serum levels of miR-205 and miR-221 in each group were detected, and their relationships with clinicopathological characteristics of patients with colon cancer were analyzed. The diagnostic values of the serum levels of miR-205 and miR-221 in colon cancer were analyzed by receiver operating characteristic (ROC) curve. Pearson correlation analysis was used to analyze the correlation between the serum levels of miR-205 and miR-221. Results: The serum levels of miR-205 in colon cancer group, benign lesion group and control group were 2.84±0.96, 1.16±0.27 and 1.05±0.23, with a statistically significant diffe-rence (F=10.113, P<0.001). The serum levels of miR-221 in the three groups were 1.95±0.74, 0.37±0.08 and 0.32±0.05, with a statistically significant difference (F=12.416, P<0.001). Further pairwise comparisons found that the serum levels of miR-205 and miR-221 in colon cancer group were significantly higher than those in benign lesion group and control group (all P<0.001). The serum levels of miR-205 and miR-221 in patients with colon cancer were related with TNM stage (t=5.412, P<0.001; t=6.103, P<0.001), degree of tumor differentiation (t=4.573, P=0.028; t=4.805, P=0.013) and with or without lymph node metastasis (t=5.837, P<0.001; t=7.410, P<0.001). ROC curve analysis showed that the optimal cut-off values of the serum levels of miR-205 and miR-221 for the diagnosis of colon cancer were 2.17 and 1.30, respectively. The area under the curve of the two combined diagnostic method for colon cancer was the largest (0.924, 95%CI: 0.865-0.983), with the sensitivity and specificity of 91.3% and 87.4%. The correlation analysis showed that the serum levels of miR-205 and miR-221 were positively correlated in patients with colon cancer (r=0.837, P<0.001). Conclusion The serum levels of miR-205 and miR-221 are significantly increased in patients with colon cancer, and the two combined detection has a high value for the diagnosis of colon cancer.