Chemotherapy-induced neuropathic pain (CINP) is a common adverse reaction in cancer chemotherapy, which is dose-dependent. CINP initially presents as acute pain syndrome and can lead to chronic neuropathic pain if not cured or recurrent. The pathophysiological mechanisms of CINP include mitochondrial dysfunction, calcium dyshomeostasis, oxidative stress, activation of apoptotic pathways, loss of myelin and non-myelin fibers, activation of the immune system, and increased expression of ion channels, etc. The mechanism of neuropathic pain induced by different chemotherapeutic drugs is different. There is a lack of effective CINP control measures and the highly recognized therapeutic drug is serotonin and norepinephrine reuptake inhibitor duloxetine.

Chemotherapy-induced neuropathic pain (CINP) is a common adverse reaction in cancer chemotherapy, which is dose-dependent. CINP initially presents as acute pain syndrome and can lead to chronic neuropathic pain if not cured or recurrent. The pathophysiological mechanisms of CINP include mitochondrial dysfunction, calcium dyshomeostasis, oxidative stress, activation of apoptotic pathways, loss of myelin and non-myelin fibers, activation of the immune system, and increased expression of ion channels, etc. The mechanism of neuropathic pain induced by different chemotherapeutic drugs is different. There is a lack of effective CINP control measures and the highly recognized therapeutic drug is serotonin and norepinephrine reuptake inhibitor duloxetine.

The literature and relevant books on the scalp needling schools were retrieved to collect the main scalp needling schools and compare the point location principles and needling techniques so as to optimize the scalp needling scheme. Currently there are ten major schools of scalp acupuncture, representing for example by,and, etc. The principles of stimulating localization are different among the schools, in which,'s skull line localization is mainly for the treatment of cerebrovascular diseases,prefers the penetrating technique for the treatment of pain and mental disorders according to traditional meridian theory, and the other schools take the cortical functions into account for the stimulating localization. Regarding needling techniques,stresses on the deep puncture to the periosteum, and the rest school masters puncture beneath the bonnet aponeurosis. The quick rotation of needle is required in's scalp needling,'s skull needle,and the needling technique for opening brain and promotion collateral. The long-term needle retaining is required in's scalp needling and's scalp needling. It is believed that the stimulating localization principles are not standardized, the theoretic evidences are not clear and the needling depth is different among the schools. There are no standard criteria on needling angle, depth, direction, rotating speed and needle retaining time. The evidence-based medicine is recommended. Through strict scientific design, based on the clinical and experimental evidences, it is required to determine the theoretic scientific evidence of scalp acupuncture, the specificity of stimulating areas, the effective stimulating areas and quantify the needling manipulations and clarify the optimal scheme of scalp needling.

Objective: to select the optimal acupuncture therapeutic projects on cerebral infarction-related motor dysfunction of lower limbs. Methods: to optimize the combination projects on 4 factors and 3 levels affecting the acupuncture effect on cerebral infarction by using orthogonal design targeting on patients with cerebral infarction-related motor dysfunction of lower limbs, and Fugl-Meyer score of limb motor function was taken as indexes. Results: The relatively optimal Fugl-Meyer score of lower limb function can be obtained within 3-day duration of cerebral infarction. Conclusions: As far as the considered factors and levels are concerned, the previously mentioned project is the optimal acupuncture therapeutic project for cerebral infarction-related motor dysfunction of lower limbs.