Objective: To investigate the epidemiological characteristics of hepatitis C in Beilin District, Xi'an City, Shaanxi Province from 2014 to 2023, so as to provide the evidence for optimizing hepatitis C prevention and control strategies. Methods: Data on hepatitis C cases in Beilin District from 2014 to 2023 were collected from the Infection Disease Surveillance System of the China Information System for Disease Control and Prevention. The crude incidence of hepatitis C was calculated, and the standardized incidence was computed using the age composition of the standard population from the Seventh National Population Census in 2020. Descriptive epidemiological methods were employed to analyze the demographic, temporal, and regional distribution characteristics of hepatitis C cases. The average annual percent change (AAPC) was used to analyze the trend in incidence of hepatitis C in Beilin District from 2014 to 2023. Results: From 2014 to 2023, a total of 2 423 hepatitis C cases were reported in Beilin District, with a crude incidence of 35.91/105 and a standardized incidence of 30.63/105. The crude and standardized incidence of hepatitis C in males were higher than in females (41.93/100 000 vs. 28.68/100 000, 36.81/100 000 vs. 22.69/100 000, both P<0.05). From 2014 to 2023, the standardized incidence among total population, males and females showed decreasing trends, with AAPC values of -7.411%, -6.147%, and -9.267%, respectively (all P<0.05). The age group of 50-<60 years had the highest number of reported hepatitis C cases, with 769 cases, accounting for 31.74%. In contrast, the age group of ≥80 years had the highest crude incidence, at 88.84/105. Occupations were predominantly characterized by housework and unemployment, with 892 cases, accounting for 36.81%. Regarding monthly distribution, the higher numbers of cases were reported in May and March, with 242 and 238 cases, respectively. Nanyuanmen Subdistrict, Zhangjiacun Subdistrict, and Wenyi Road Subdistrict ranked the top three in terms of standardized incidence of hepatitis C, with 44.15/100 000, 42.52/100 000, and 39.80/100 000, respectively. Conclusions From 2014 to 2023, the incidence of hepatitis C in Beilin District showed an overall decreasing trend. Males, middle-aged and elderly individuals, and housework or unemployed were key populations for targeted hepatitis C prevention and control. It is recommended to strengthen control measures in high-incidence areas.