Objective This qualitative study aimed to explore the home-based exercise rehabilitation experiences of elderly patients after hip fracture surgery,in order to provide references for exercise intervention during rehabili-tation period.Methods Objective sampling method was used to select 13 elderly hip fracture patients who were hospitalized in the joint surgery department of a tertiary A hospital in Beijing from August 2023 to June 2024 as the research subjects.Semi-structured interviews were conducted,and the interview data were sorted and analyzed by content analysis method.Results The home-based exercise rehabilitation experience of elderly patients after hip fracture surgery can be summarized into 3 themes,including multi-dimensional self-empowerment,use of dynamic personalized skills,full cycle balance reconstruction.Conclusion Patients after hip fracture surgery have rich expe-riences in home exercise rehabilitation,including self-empowerment,exercise skills and balance reconstruction.Nurs-ing staff should strengthen long-term follow-up,according to the real experience and feeling of the patient's home exercise rehabilitation in the whole cycle,actively assist the patients to self-empower,and use various exercise skills to constantly rebuild balance to achieve rehabilitation.

Objective:To construct a narrative nursing intervention plan for post-traumatic growth (PTG) in breast cancer patients and evaluate its effectiveness.Methods:Based on PTG model and the core principles of narrative nursing techniques, an intervention plan was constructed, consisting of three themes. The first unit, "Me and Them, " used externalization techniques to construct deliberate rumination. The second unit, "What Kind of Person Am I, " used deconstruction and rewriting techniques to promote effective disease coping. The third unit, "We Are Together, " applied external witnesses and therapeutic documentation techniques to enhance social support and consolidate growth. Individualized face-to-face interventions were implemented, with each unit receiving one session lasting 1 to 1.5 hours, for a total of three sessions. Using purposive sampling, 42 breast cancer patients hospitalized in the Daytime Ward of Beijing Tiantan Hospital from July to October 2024 were selected. These patients were divided into an intervention group, which received the narrative nursing intervention plan, and a control group, which received routine nursing care, with 21 patients in each group. The Post-Traumatic Growth Inventory (PTGI) and the Chinese version of the Event-Related Rumination Inventory (C-ERRI) were used to assess the patients before and after the intervention.Results:After the intervention, the intervention group showed significantly higher scores on the PTGI and deliberate rumination in the C-ERRI compared to the control group, while the intervention group had significantly lower scores on intrusive rumination in the C-ERRI compared to the control group. The differences were statistically significant ( P<0.05) . Conclusions:The narrative nursing intervention plan for PTG in breast cancer patients constructed in this study is scientifically sound and feasible. It can help breast cancer patients enhance their PTG levels and develop deliberate rumination.

Objective This qualitative study aimed to explore the home-based exercise rehabilitation experiences of elderly patients after hip fracture surgery,in order to provide references for exercise intervention during rehabili-tation period.Methods Objective sampling method was used to select 13 elderly hip fracture patients who were hospitalized in the joint surgery department of a tertiary A hospital in Beijing from August 2023 to June 2024 as the research subjects.Semi-structured interviews were conducted,and the interview data were sorted and analyzed by content analysis method.Results The home-based exercise rehabilitation experience of elderly patients after hip fracture surgery can be summarized into 3 themes,including multi-dimensional self-empowerment,use of dynamic personalized skills,full cycle balance reconstruction.Conclusion Patients after hip fracture surgery have rich expe-riences in home exercise rehabilitation,including self-empowerment,exercise skills and balance reconstruction.Nurs-ing staff should strengthen long-term follow-up,according to the real experience and feeling of the patient's home exercise rehabilitation in the whole cycle,actively assist the patients to self-empower,and use various exercise skills to constantly rebuild balance to achieve rehabilitation.

Objective:To construct a narrative nursing intervention plan for post-traumatic growth (PTG) in breast cancer patients and evaluate its effectiveness.Methods:Based on PTG model and the core principles of narrative nursing techniques, an intervention plan was constructed, consisting of three themes. The first unit, "Me and Them, " used externalization techniques to construct deliberate rumination. The second unit, "What Kind of Person Am I, " used deconstruction and rewriting techniques to promote effective disease coping. The third unit, "We Are Together, " applied external witnesses and therapeutic documentation techniques to enhance social support and consolidate growth. Individualized face-to-face interventions were implemented, with each unit receiving one session lasting 1 to 1.5 hours, for a total of three sessions. Using purposive sampling, 42 breast cancer patients hospitalized in the Daytime Ward of Beijing Tiantan Hospital from July to October 2024 were selected. These patients were divided into an intervention group, which received the narrative nursing intervention plan, and a control group, which received routine nursing care, with 21 patients in each group. The Post-Traumatic Growth Inventory (PTGI) and the Chinese version of the Event-Related Rumination Inventory (C-ERRI) were used to assess the patients before and after the intervention.Results:After the intervention, the intervention group showed significantly higher scores on the PTGI and deliberate rumination in the C-ERRI compared to the control group, while the intervention group had significantly lower scores on intrusive rumination in the C-ERRI compared to the control group. The differences were statistically significant ( P<0.05) . Conclusions:The narrative nursing intervention plan for PTG in breast cancer patients constructed in this study is scientifically sound and feasible. It can help breast cancer patients enhance their PTG levels and develop deliberate rumination.

Background and purpose:In 2016 the National Cancer Institute(NCI)decided stopping to use NCI-60 cell lines for drug screening,suggesting that tumor cell lines were losing their value as a tool for drug discovery and basic research.The reason for NCI-60 cells'retirement'was that the preclinical studies based on traditional cellular and animal models did not obtain the corresponding expected efficacy in clinical trials.Since the major cancer behaviors,such as proliferation and metastasis,are fundamentally altered with long-term culture,the tumor cell lines are not representative of the characteristics of cancer in patients.Currently,scientists hope to create a new cancer model that are derived from fresh patient samples and tagged with details about their clinical past.Our purpose was to create patient-derived breast cancer primary cell lines as new cancer model for drug screening and basic research.Methods:Breast cancer tissues were collected in the Department of Breast Surgery,Affiliated Hospital of Guizhou Medical University.The collection of tumor tissue samples was approved by the Ethics Committee of the Affiliated Hospital of Guizhou Medical University(approval number:2022 ethics No.313),and the collection and use of tumor tissues complied with the Declaration of Helsinki.The primary breast cancer cell lines were isolated from the patient's breast cancer tissues and cultured in BCMI medium.After the cells proliferated,the media were replaced with DEME medium.Cell line STR genotyping was done to determine cell-specific genetic markers and identification.Clone formation assay and transplantation assay were done to analyze the ability of breast cancer primary cell lines to form tumors.Results:We created 6 primary breast cancer cell lines.The 6 primary breast cancer cell lines from the patients were tagged with the definitively clinicopathological features,clinical diagnosis,therapeutic regimens,clinical effectiveness and prognostic outcomes.The STR genotyping assays identified the genetic markers and determined the identities of the 6 primary breast cancer cell lines.Clone formation assays and transplantation assay showed that the proliferative capacities of the patient-derived primary breast cancer cell lines were significantly greater compared with the conventional breast cancer cell lines.Conclusion:We created a panel of 6 patient-derived primary breast cancer cell lines as new cancer model for drug screening and basic research in breast cancer.

Objective:To explore the evaluation effect of ultrasonography and Pirani score on tarsal deformity, treatment effect and pseudo-correction of congenital clubfoot in infants and young children, and the correlation between the two methods.Methods:This is a retrospective case series study. The clinical data of 26 children (40 feet) with congenital clubfoot who were evaluated by ultrasonography in the Third Affiliated Hospital of Zhengzhou University from January 2020 to January 2023 were retrospectively collected. There were 16 males and 10 females. The age at the first ultrasound examination was ( M(IQR)) 9.0 (18.0) days (range: 1 to 46 days). All patients were treated with Ponseti method by the same physician. The Pirani scores before and after treatment and at the last examination, and the talonavicular angle, calcaneocuboid angle and tibiocalcaneal angle measured by ultrasound were collected, and the treatment and follow-up were recorded. Paired sample t test, repeated measures analysis of variance or Kruskal-Wallis test were used for data comparison, and Spearman correlation analysis was used for correlation analysis. The receiver operating characteristic curve was used to calculate the efficacy of ultrasound in evaluating different Pirani scores. Results:The number of plaster fixation in 26 children was 4.0 (1.0) times (range: 2 to 8 times). The medial talonavicular angle and posterior tibiocalcaneal angle were significantly improved after treatment and at the last follow-up compared with those before treatment, and the differences were statistically significant (all P<0.01). There was no difference in lateral calcaneocuboid angle before and after treatment and at the last follow-up ( F=1.971, P>0.05). Pseudo-correction occurred in 2 cases (2 feet) during the treatment, with an incidence of 5%. Correlation analysis showed that there was a moderate positive correlation between talonavicular angle and Pirani midfoot score ( r=0.480, P<0.01). There was no correlation between calcaneocuboid angle and Pirani midfoot score ( r=0.114, P=0.105). There was a moderate negative correlation between tibial heel angle and Pirani hindfoot score ( r=-0.566, P<0.01). The cut-off point of Pirani midfoot score of 1.5 was 38.78°, the sensitivity was 0.90, the specificity was 0.56, and the area under the curve was 0.75. The cut-off value of angle was 27.51 °, the sensitivity was 0.16, the specificity was 0.92, and the area under the curve was 0.44.The cut-off points of Pirani midfoot score of 3.0 were 45.08°and 9.96°, the sensitivity was 0.94 and 0.91, the specificity was 0.37 and 0.42, and the area under the curve was 0.59 and 0.62, respectively. The cut-off values of Pirani hindfoot score of 2.0 and 3.0 were 167.46° and 160.15°, respectively. The sensitivity was 0.75 and 0.67, the specificity was 0.81 and 0.83, and the area under the curve was 0.78 and 0.71, respectively. Conclusion:Ultrasound can complement with Pirani score, visually and dynamically observe the morphology and position changes of talonavicular joint, calcaneocuboid joint and tibiotalocalcaneal joint, monitor the recovery and pseudo-correction of tarsal bones, and better evaluate the therapeutic effect.

Objective:To explore the evaluation effect of ultrasonography and Pirani score on tarsal deformity, treatment effect and pseudo-correction of congenital clubfoot in infants and young children, and the correlation between the two methods.Methods:This is a retrospective case series study. The clinical data of 26 children (40 feet) with congenital clubfoot who were evaluated by ultrasonography in the Third Affiliated Hospital of Zhengzhou University from January 2020 to January 2023 were retrospectively collected. There were 16 males and 10 females. The age at the first ultrasound examination was ( M(IQR)) 9.0 (18.0) days (range: 1 to 46 days). All patients were treated with Ponseti method by the same physician. The Pirani scores before and after treatment and at the last examination, and the talonavicular angle, calcaneocuboid angle and tibiocalcaneal angle measured by ultrasound were collected, and the treatment and follow-up were recorded. Paired sample t test, repeated measures analysis of variance or Kruskal-Wallis test were used for data comparison, and Spearman correlation analysis was used for correlation analysis. The receiver operating characteristic curve was used to calculate the efficacy of ultrasound in evaluating different Pirani scores. Results:The number of plaster fixation in 26 children was 4.0 (1.0) times (range: 2 to 8 times). The medial talonavicular angle and posterior tibiocalcaneal angle were significantly improved after treatment and at the last follow-up compared with those before treatment, and the differences were statistically significant (all P<0.01). There was no difference in lateral calcaneocuboid angle before and after treatment and at the last follow-up ( F=1.971, P>0.05). Pseudo-correction occurred in 2 cases (2 feet) during the treatment, with an incidence of 5%. Correlation analysis showed that there was a moderate positive correlation between talonavicular angle and Pirani midfoot score ( r=0.480, P<0.01). There was no correlation between calcaneocuboid angle and Pirani midfoot score ( r=0.114, P=0.105). There was a moderate negative correlation between tibial heel angle and Pirani hindfoot score ( r=-0.566, P<0.01). The cut-off point of Pirani midfoot score of 1.5 was 38.78°, the sensitivity was 0.90, the specificity was 0.56, and the area under the curve was 0.75. The cut-off value of angle was 27.51 °, the sensitivity was 0.16, the specificity was 0.92, and the area under the curve was 0.44.The cut-off points of Pirani midfoot score of 3.0 were 45.08°and 9.96°, the sensitivity was 0.94 and 0.91, the specificity was 0.37 and 0.42, and the area under the curve was 0.59 and 0.62, respectively. The cut-off values of Pirani hindfoot score of 2.0 and 3.0 were 167.46° and 160.15°, respectively. The sensitivity was 0.75 and 0.67, the specificity was 0.81 and 0.83, and the area under the curve was 0.78 and 0.71, respectively. Conclusion:Ultrasound can complement with Pirani score, visually and dynamically observe the morphology and position changes of talonavicular joint, calcaneocuboid joint and tibiotalocalcaneal joint, monitor the recovery and pseudo-correction of tarsal bones, and better evaluate the therapeutic effect.

Objective To construct early phase Ⅰ cardiopulmonary rehabilitation program for patients with Type A aortic dissection and to evaluate its clinical effects.Methods From January 2021 to October 2022,type A aortic dissection patients of a tertiary hospital in Beijing was selected by the destination sampling.They were divided into a control group and an intervention group.The intervention group was given early phase Ⅰcardiopulmonary rehabilitation program for patients with type A aortic dissection and the control group was given routine care.The 6-minute walking experiment(6MWT),Borg subjective fatigue score,the first time out of bed,the incidence of hypoxemia and related complications,and the incidence of adverse events related to rehabilitation nursing were compared between the 2 groups.Results A total of 130 cases were selected,among which 20 cases were excluded because of surgical complications and self-withdrawal.A total of 110 cases were finally included,with 57 cases in the intervention group and 53 cases in the control group.The results of walking distance of 6MWT,Borg subjective fatigue score and incidence of hypoxemia had statistical significance between the 2 groups(P＜0.05).The results of the time of the first time out of bed and the incidence of complications and the incidence of adverse events related to rehabilitation nursing had no statistical significance between the 2 groups(P＞0.05).Conclusion Early phase Ⅰ cardiopulmonary rehabilitation program for patients with type A aortic dissection benefits the improvement of the motor function,the reduction of incidence of hypoxemia.

Objective:To explore the effect of functional exercise rehabilitation bridging mode on the functional exercise and self-management ability of patients after breast cancer surgery, so as to provide reference for guiding patients to achieve full process management and self-management and rehabilitation.Methods:Using a non randomized grouping quasi experimental design, 202 patients with breast cancer undergoing surgical treatment were selected from the breast surgery department of Yuhuangding Hospital in Yantai from March to July 2021 through convenient sampling. The control group received routine nursing and rehabilitation guidance. The intervention group adopted a rehabilitation bridging mode for postoperative functional exercise on the basis of routine nursing care. The functional exercise compliance rate and self management ability of the two groups of patients after the intervention were evaluated.Results:In the intervention group, the rate of functional exercise reaching the standard, the rate of functional exercise knowledge awareness, correctness and compliance in self-management ability of breast cancer patients were as follows: 93.1%(95/102), 71.6%(73/102), 80.4%(82/102), 73.5%(75/102), which were higher than the control group 84.0%(84/100), 46.0%(46/100), 52.0%(52/100), 17.0%(17/100). The differences were statistically significant ( χ2 values were 4.18-65.06, all P<0.05). Conclusions:The rehabilitation bridging mode could connect the functional exercise needs of patients at different stages of rehabilitation, provide personalized, continuous, and standardized functional exercise guidance for patients, help them improve the effect of functional exercise, and improve their self management ability.