Objective:To observe the clinical efficacy of mouse nerve growth factor (mNGF) combined with rehabilitation on children with global developmental delay(GDD).Methods:It was a prospective multicenter clinical randomized controlled trial (RCT) involving 120 children with GDD admitted to 5 hospitals in China from May 2020 to January 2022.They were randomly divided into mNGF group and conventional rehabilitation group using block randomization method.All children were managed by standardized rehabilitation after recruitment, and those in the mNGF group were additionally given mNGF injections.All subjects were surveyed using the Gesell Development Diagnosis Schedules(GDDS) at baseline, 90 days and 120 days after treatment, and their developmental quotient (DQ) was recorded.Clinical efficacy was analyzed by the paired t-test, rank sum test and Chi- squared test. Results:After 90 days of treatment and the continuous follow-up to 120 days, the increases in the DQ of gross motor (7.520±13.900 vs.0.450±11.459), fine motor (7.800±15.346 vs.1.250±11.581), adaptive behavior (7.730±13.428 vs.2.100±12.022) and personal-social behavior (6.780±11.651 vs.1.780±10.120) than baseline were significantly higher in mNGF group than those of conventional rehabilitation group (all P<0.05). Serious adverse events and important drug-related medical events were not reported. Conclusions:mNGF combined with rehabilitation effectively enhances the development levels of gross motor, fine motor, adaptive behavior and personal-social behavior, and continuously improves the condition of GDD in children with a high safety.

Objective:To observe the effect of recuperation pathway based interventions on uric acid and lipid of sea diving personnel in a naval recuperation center.Methods:A total of 1 149 cases of sea diving personnel admitted to a Recuperation Center for PLA Naval Special Duty Personnel from July 2015 to December 2020 were studied. After admission, their blood samples were taken for testing uric acid and lipid. Those with abnormal levels of uric acid and lipid were given the interventions based on recuperation pathway, and their levels of uric acid and lipid were re-examined 15 days after the intervention.Results:After intervention, the levels of uric acid, total cholesterol, triglyceride, and low-density lipoprotein were lower than those before intervention, and the differences were statistically significant ( P<0.05). Conclusion:The recuperation pathway based intervention plan adopted by the center can effectively reduce the uric acid and lipid levels of sea diving personnel. With reasonable recuperation plans, better improvement in the health of sea diving personnel can be achieved.

Objective:To observe the effect of recuperation pathway based interventions on uric acid and lipid of sea diving personnel in a naval recuperation center.Methods:A total of 1 149 cases of sea diving personnel admitted to a Recuperation Center for PLA Naval Special Duty Personnel from July 2015 to December 2020 were studied. After admission, their blood samples were taken for testing uric acid and lipid. Those with abnormal levels of uric acid and lipid were given the interventions based on recuperation pathway, and their levels of uric acid and lipid were re-examined 15 days after the intervention.Results:After intervention, the levels of uric acid, total cholesterol, triglyceride, and low-density lipoprotein were lower than those before intervention, and the differences were statistically significant ( P<0.05). Conclusion:The recuperation pathway based intervention plan adopted by the center can effectively reduce the uric acid and lipid levels of sea diving personnel. With reasonable recuperation plans, better improvement in the health of sea diving personnel can be achieved.