Course-based ideological and political education(CBIPE)is an innovative approach to implementing ideological and political education in Chinese universities.It aims to integrate ideological and political education with disciplinary education,helps students improve their thinking and understanding of national,social,moral and ethical issues while studying their major sub-jects.This article takes the immunology course in the Biology Science Education major at Anshun University as an example to explore ideological and political education teaching practices based on the scientific spirit.By combining the content of adjuvants in immunolo-gy with the development of COVID-19 vaccines,the article tries to stimulate students'interest in immunology,guide their reflection on the application and significance of immunology knowledge in society,and cultivate their scientific spirit.It provides reference and inspiration for the implementation of CBIPE in relevant majors or courses.

Course-based ideological and political education(CBIPE)is an innovative approach to implementing ideological and political education in Chinese universities.It aims to integrate ideological and political education with disciplinary education,helps students improve their thinking and understanding of national,social,moral and ethical issues while studying their major sub-jects.This article takes the immunology course in the Biology Science Education major at Anshun University as an example to explore ideological and political education teaching practices based on the scientific spirit.By combining the content of adjuvants in immunolo-gy with the development of COVID-19 vaccines,the article tries to stimulate students'interest in immunology,guide their reflection on the application and significance of immunology knowledge in society,and cultivate their scientific spirit.It provides reference and inspiration for the implementation of CBIPE in relevant majors or courses.

Post-stroke depression (PSD) is one kind of the common mental diseases after stroke, and the prevention and treatment of PSD are very difficult. TREK-1, a two-pore domain potassium channel, is an important target in the pathogenesis of stroke and PSD, and it is closely related to neuroprotection and emotion regulation; inhibition of activity of TREK-1 channel can exert significant antidepressant effect. In recent years, TREK-1 channel blocker Spadin and Spadin analogs are discovered, and they have a relatively significant effect on ischemic stroke and PSD. In this paper, the research progress on the discovery, efficacy and therapeutic value of Spadin and Spadin analogs in PSD are summarized as follows.