Objective: To report the clinical data of two patients with prostatic hyperplasia and bladder uric acid stones，so as to provide reference for clinical practice. Methods: Clinical data of two patients successfully undergoing blue laser lithotripsy in Department of Urology，Zhenba County People's Hospital were retrospectively analyzed，including clinical manifestations，surgical methods，treatment outcomes and complications. Results: Both patients sought medical care due to progressive dysuria or hematuria.B ultrasound and magnetic resonance imaging confirmed bladder calculi and prostatic hyperplasia.One patient also had large blood clots in the bladder cavity.Both patients received transurethral blue laser prostate vaporization + transurethral bladder stone holmium laser lithotripsy.The stone surface was dark yellow，with no obvious pores，fine particles or spike protrusion.Blue laser produced an “ablative” phenomenon similar to vaporization，and then stones became smaller and fragmented.The lithotripsy lasted for 11 min and 8 min，respectively.There were multiple bladder mucosal injuries due to constant drift of stones during operation.Stone composition analysis suggested uric acid stones.After 3 months of follow-up，both patients had smooth postoperative urination，good urine control，and no stone recurrence. Conclusion: Blue laser can be applied to crush uric acid stones，and the bladder mucosa should be protected during lithotripsy.

Osteoarthritis(OA)is a degenerative joint disease primarily characterized by articular cartilage degeneration.Autophagy is a crucial intracellular homeostatic system that plays a vital role in maintaining normal cartilage function.By regulating cell apoptosis and repairing damaged chondro-cytes,autophagy protects cartilage,and dysfunction in chondrocyte autophagy is an important patho-genic mechanism underlying cartilage degeneration in OA.MicroRNAs(miRNA)can regulate gene expression and play a key role in chondrocyte development and functional maintenance.MiRNA in-volved in the regulation of autophagy are aberrantly expressed in OA,suggesting that miRNAs may serve as potential targets and biomarkers for early prediction,diagnosis,and effective treatment of OA.This review discussed the role of autophagy in OA and the regulatory role of miRNA in OA de-velopment,with a focus on the role of miRNA-mediated regulation of chondrocyte autophagy in OA pathogenesis and its potential therapeutic value.