Objective To investigate the early diagnosis of ectopic pregnancy by transvaginal three-dimensional ultrasound combined with serum carbohydrate antigen 125(CA125),vascular endothelial growth factor(VEGF)and anti-Müllerian hormone(AMH).Methods Totally 96 patients with ectopic pregnancy and 48 pregnant women with normal intrauterine pregnancy diagnosed and treated from May 2019 to June 2022 were selected as study objects.Ultrasonographic parameters(vascularization index[VI],flow index[FI],vascularization flow index[VFI]),and serum CA125,VEGF and AMH were compared between ectopic pregnancy group and intrauterine pregnancy group.Logistic regression model was used to construct diagnostic models by ultrasonic parameters,serum CA125,VEGF and AMH ultrasonic parameters,serum CA125,VEGF and AMH,and six combined parameters.Receiver operating characteristic(ROC)curve was used to evaluate the area under the curve(AUC)values,sensitivities and specificities of ultrasonic parameters(VI,FI,VFI),CA125,VEGF,AMH,and six combined parameters for the diagnosis of ectopic pregnancy.Results The ectopic pregnancy group had lower VI,FI,VFI and AMH and higher CA125 and VEGF than the intrauterine pregnancy group(all P<0.05).ROC curve analysis showed that the AUC of VI,FI,VFI,CA125,VEGF,AMH and combined parameters for the diagnosis of ectopic pregnancy were 0.753,0.644,0.765,0.763,0.768,0.739 and 0.995,respectively.The AUC of the combined parameters was larger than those of VI,FI,VFI,CA125,VEGF and AMH(P<0.05).Conclusion Transvaginal three-dimensional ultrasound combined with serum CA125,VEGF and AMH has high diagnostic value for early ectopic pregnancy and is worthy of clinical application.

Objective To evaluate the role of MSCT in diagnosing Cantrell syndrome.Methods Five patients with Cantrell syndrome were enrolled in this study retrospectively.All clinical data,especially imaging data were collected at enrolment.Maximum intensity projection(MIP),multi planar reconstruction(MPR)and volume rendering(VR)of the analysis method of MSCT were used to describe the characteristics of Cantrell syndrome.Results The age of 5 patients ranged from 2 days to 24 years,4(4/5)cases were Cantrell syndrome and 1(1/5)case was incomplete Cantrell syndrome,3(3/5)cases were confirmed by surgery.Five cases were all diagnosed as ectocardia,thoracocyllosis,pericardium defect and diaphragm defect with MSCT.Four had sternum dysplasia,abdominal wall defect, 3 had ventricular diverticulum,2 had umbilical hernia.Conclusion MSCT can be used in accurately diagnosing Cantrell syndrome in clinical work.

Objective To study the consistency between pathology and the single and combined diagnosis of negative breast cancer by ultrasonography and mammography.Methods 90 clinical case data of patients with palpable negative breast tumors and mammography revealed small calcifications were retrospective analyzed.All patients were received the high frequency ultrasound.The value of two methods and combined diagnosis in the diagnosis of breast cancer with palpation negative were compared,which the pathological biopsy was the gold standard.Results The pathological showed that there were 58 cases of benign tumors,32 cases of malignant tumors,10 cases of stage 0,18 cases of stage Ⅰ,4 cases of stage Ⅱ.The high frequency ultrasonography was consistent with pathological(Kappa =0.641).The AUC of diagnosiing the breast cancer was 0.775.The molybdenum target radiography was consistent with pathological (Kappa =0.725),and the AUC was 0.830.The high frequency ultrasonography combined with molybdenum target radiography was highly consistent with pathological(Kappa =0.879),and the AUC was 0.934.The accuracy of combined diagnosis was higher than that of high frequency ultrasound (P ＜ 0.05) and molybdenum target radiography(P ＞ 0.05).Conclusion The high frequency ultrasonography and molybdenum target radiography have advantages in the diagnosis of palpable negative breast cancer.The joint diagnosis helps to achieve complementary strengths,has high consistency with pathology,and help to improve the diagnostic accuracy.