Methodology: An outpatient chart review was done in 2 tertiary institutions in Metro Manila. Purposive sampling was done. PCOS cases from January 2014 to December 2015 were classified into four phenotypes. One-way ANOVA was used to assess the association of phenotypes with infertility, abortion and cardiometabolic risks using absolute values.

Results: PCOS prevalence was 12.29%. There were 195 cases eligible for the study. Phenotype D was the most common phenotype followed by Phenotype A. The least common phenotypes were Phenotypes B and C. More than half were obese with 58% exhibiting central obesity. Analysis of variance showed significant association of Phenotype A to hyperandrogenism (p value < 0.001), hypertension (p value 0.002), impaired glucose tolerance (p vlaue 0.009), diabetes mellitus (p value 0.009) and metabolic syndrome (p value < 0.001). Phenotype D was significantly associated with elevated triglycerides (p vlaue 0.049), LDL (p value 0.014) and VLDL (p value 0.015) and reduced HDL levels (p value 0.006). There was no significant association of phenotypes with infetility (p value 0.22), abortion (p vlaue 0.90), abnormal BMI (p value 0.27) and abdominal obesity (p value 0.115).

Conclusion: Phenotype A was associated with hyperandrogenism, hypertension, impaired glucose tolerance, diabetes mellitus and metabolic syndrome, while Phenotype D was associated with dyslipidemia. Hence, knowledge of PCOS phenotype classification is needed to implement comprehensive therapeutic approach for PCOS patients to prevent early and long-term complications.

 

Key words: Polycystic ovary syndrome, phenotypes, infertility, abortion, metabolic syndrome

Human ; Female ; Polycystic Ovary Syndrome

The need for simplified in-vitro fertilization (IVF) treatment approaches with the aim of reducing treatment burden and to prevent drop-outs after a failed IVF cycle can be met by the use of corifollitropin alfa for COS in association with a GnRH antagonist protocol. This is a report of the first local case of a successful pregnancy using corifollitropin alfa in IVF. This is a case of a 33-year-old G3 P0 (0030) whose partner has teratozoospermia, COS using corifollitripin alfa yielded eight mature oocytes with no occurrence of OHSS. Six oocytes were fertilized using ICSI with six good quality embryos reaching cleavage stage. Two grade 1 embryo sat day 3 cleavage stage were transferred. A clinical pregnancy was documented at 7 weeks age of gestation. Congenital anomaly scanning at 24 weeks age of gestation revealed a grossly normal fetus. Patient delivered a healthy, live, term baby boy. Review of literature suggests that corrifollitropin alfa is as effective as rFSH in delivering live birth rate, ongoing pregnancy rate and clinical pregnancy rate. The sustained and higher FSH immunoreactivity concentrations and the inability for dose adjustment after treatment with a single dose of corifollitropin compared with the daily rFSH regimen underscored the need for careful patient selection in the use of corifollitropin alfa.

Human ; Female ; Adult ; Corifollitropin Alfa (elonva) ; Recombinant Follicle Stimulating Hormone (rfsh) ; Controlled Ovarian Stimulation (cos) ; In Vitro Fertilization (ivf) ; Intracytoplasmic Sperm Injection (icsi)