1.Clinical Observation on Acupuncture Combined with Western Medicine in the Treatment of Rheumatoid Arthritis Complicated with Mild Anemia Under the Guidance of"Dongyuan Acupuncture"
Fengzhi TAN ; Min YU ; Longlin ZHANG
Journal of Guangzhou University of Traditional Chinese Medicine 2025;42(4):907-913
Objective To observe the clinical efficacy of acupuncture combined with western medicine in the treatment of rheumatoid arthritis(RA)complicated with mild anemia under the guidance of"Dongyuan acupuncture".Methods A total of 80 cases of patients definitively diagnosed as RA complicated with mild anemia of deficiency of qi and blood were selected and randomly divided into the observation group and the control group according to the random number table method,those who were admitted to the wards and outpatient clinics of the Department.of Rheumatology,Chongqing Hospital of The First Affiliated Hospital of Guangzhou University of Chinese Medicine from February 2024 to September 2024,with 40 cases in each group.The control group was given conventional treatment with western medicines,while the observation group was additionally treated with acupuncture under the guidance of"Dongguan acupuncture".The course of treatment covered four consecutive weeks.After one month of treatment,the clinical efficacy of the two groups was evaluated,and the changes in traditional Chinese medicine(TCM)syndrome scores and Visual Analogue Scale(VAS)of pain scores,as well as Disease Activity Scores(DAS-28)before and after treatment were observed in the two groups.The changes of rheumatoid factor(RF),C-reactive protein(CRP),erythrocyte sedimentation rate(ESR),red blood cell count(RBC),and hemoglobin(Hb)levels before and after treatment were compared between the two groups.The safety and incidence of adverse reactions in the two groups were also evaluated.Results(1)After treatment,the TCM syndrome scores of the patients in the observation group were improved significantly(P<0.05),and the improvement in the observation group was significantly superior to that in the control group,the difference being statistically significant(P<0.05).(2)After treatment,the VAS scores and DAS-28 scores of the patients in the two groups were improved significantly(P<0.05),and the improvement in the observation group was significantly superior to that in the control group,the difference being statistically significant(P<0.05).(3)After treatment,the RF,CRP,and ESR levels of patients in the two groups were improved significantly(P<0.05),and the improvement in the observation group was significantly superior to that in the control group,the difference being statistically significant(P<0.05);after treatment,there was a significant improvement in the RBC level of the observation group(P<0.05),but the difference was not statistically significant when compared with the control group(P>0.05);after treatment,the Hb level of patients in the two groups were improved significantly(P<0.05),and the improvement in the observation group was significantly superior to that in the control group,the difference being statistically significant(P<0.05).(4)The total effective rate was 95.00%(38/40)in the observation group and 87.50%(35/40)in the control group,and the efficacy of the observation group was superior to that of the control group,the difference being statistically significant(P<0.05).(5)The incidence of adverse reactions was 7.50%(3/40)in the observation group and 27.50%(11/40)in the control group,the incidence of adverse reactions in the observation group was significantly lower than that in the control group,the difference being statistically significant(P<0.05).Conclusion Under the guidance of"Dongyuan acupuncture",the application of acupuncture combined with western medicine in the treatment of RA complicated with mild anemia can not only realize the complementarity of acupuncture and medicine,improve the clinical efficacy,reduce the level of inflammatory factors,and significantly alleviate the joint symptoms of the patients,but also increase the level of blood cells,improve the anemia condition of the patients and have fewer adverse reactions,thus enhancing their quality of life.
2.Clinical Observation on the Shengqing Jiangzhuo Acupuncture Method Combined with Western Medical Treatment in Treating Gouty Nephropathy with Damp-Heat Accumulation Syndrome
Longlin ZHANG ; Fengzhi TAN ; Min YU ; Yaoyu DU ; Ao LUO ; Yihao LIU
Journal of Guangzhou University of Traditional Chinese Medicine 2025;42(7):1706-1713
Objective To evaluate the clinical efficacy of Shengqing Jiangzhuo(lifting lucid yang and lowering turbid yin)Acupuncture Method,based on the"turbidity-clearness interaction"theory,combined with western medicine in treating gouty nephropathy(GN)patients with damp-heat accumulation syndrome.Methods A total of 117 patients diagnosed with GN from September 2023 to September 2024 at the First Affiliated Hospital of Guangzhou University of Chinese Medicine Chongqing Hospital were enrolled and randomly divided into three groups,with 39 cases in each group.The western medicine group received Febuxostat Tablets,the control group was given western medicine+conventional acupuncture,and observation group was given western medicine+Shengqing Jiangzhuo Acupuncture Method.All groups received 4 weeks of treatment.Clinical efficacy,traditional Chinese medicine(TCM)syndrome scores,visual analogue scale(VAS)of pain scores,and laboratory parameters—including serum uric acid(UA),blood urea nitrogen(BUN),creatinine(Scr),estimated glomerular filtration rate(eGFR),β2-microglobulin(β2-MG),24-hour urinary protein(24h-UTP),cystatin C(CysC)were assessed.The erythrocyte sedimentation rate(ESR),and C-reactive protein(CRP)were compared before and after treatment.Results(1)The total effective rate was 71.79%(28/39)in the western medicine group,84.62%(33/39)in the control group,and 92.31%(36/39)in the observation group.The observation group demonstrated statistically significant superiority over the western medicine group(P<0.05),while showing marginally better efficacy than the control group without statistical significance(P>0.05).(2)After treatment,all three groups exhibited significant improvements in ESR,CRP,and UA levels(P<0.05).The observation group significantly outperformed the other two groups in reducing ESR and CRP levels(P<0.05),and was statistically superior to the western medicine group in lowering UA levels(P<0.05),though no significant difference was observed versus the control group for UA improvement(P>0.05).The control group showed significantly greater reductions in ESR,CRP,and UA levels than the western medicine group(P<0.05).(3)After treatment,Scr,BUN,and eGFR levels were significantly improved in all groups(P<0.05).The observation group achieved significantly better improvements in Scr and eGFR than the other two groups(P<0.05).However,no statistical difference existed between the control and western medicine groups for Scr or eGFR enhancement(P>0.05).No intergroup differences were detected in BUN improvement(P>0.05).(4)Significant differences emerged in β2-MG and CysC levels among all groups after treatment(P<0.05).Both observation and control groups demonstrated statistically significant improvements in 24-hour 24h-UTP(P<0.05),whereas the western medicine group showed no significant change(P>0.05).The observation group significantly outperformed the other groups in reducing 24h-UTP and β2-MG levels(P<0.05),and was superior to the western medicine group in lowering CysC(P<0.05),though no difference versus the control group was observed for CysC reduction(P>0.05).The control group showed no statistical advantage over the western medicine group in improving 24h-UTP,β 2-MG,or CysC(P>0.05).(5)After treatment,TCM syndrome scores and VAS scores were significantly improved in all groups(P<0.05).The observation group achieved significantly greater reductions in TCM syndrome scores and VAS scores than the western medicine group(P<0.05).The control group showed statistically superior VAS score improvement versus the western medicine group(P<0.05),but no significant differences emerged in TCM syndrome score improvement compared to either group(P>0.05).No statistical difference existed between observation and control groups for VAS score reduction(P>0.05).Conclusion Shengqing Jiangzhuo Acupuncture Method,grounded in the"turbidity-clearness interaction"theory,effectively reduces serum UA,controls inflammation,and preserves renal function in damp-heat accumulation type of GN,demonstrating significant therapeutic benefits.

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