Objective:To analyze the clinical distribution and antibiotic resistance of multidrug-resistant organism (MDRO) infections in the non-intensive care unit (ICU) of Jiangsu Provincial (Suqian) Hospital (Suqian First Hospital), providing a basis for effective implementation of infection prevention and control measures.Methods:Using the real-time monitoring system for hospital infections, this study selected 520 strains of MDROs isolated from non-ICU hospitalized patients at Jiangsu Provincial (Suqian) Hospital (Suqian First Hospital) from January 2020 to December 2023 for analysis. Based on their origin, these strains were categorized into two groups: hospital-acquired infections and community-acquired infections. The clinical distribution characteristics of MDRO infections and their resistance rates to commonly used antimicrobial agents were analyzed.Results:The average detection rate of MDRO in non-ICU over 4 consecutive years was 13.60% (782/5 750). The detection rates for methicillin-resistant Staphylococcus aureus (MRSA), carbapenem-resistant Acinetobacter baumannii (CRAB), carbapenem-resistant Pseudomonas aeruginosa (CRPA), and carbapenem-resistant Enterobacteriaceae were 46.49% (424/912), 43.81% (85/194), 18.61% (177/951), and 2.60% (96/3 693), respectively. The predominant MDROs identified were MRSA (54.23%, 282/520) and CRPA (28.65%, 149/520). Hospital-acquired infections accounted for 13.65% (71/520), while community-acquired infections comprised 86.35% (449/520). The three departments with the highest infection rates were the Department of Respiratory (22.31%), the Department of Pediatrics (15.19%), and the Department of Traditional Chinese Medicine and Burn (7.88%). All of these departments were primarily associated with community-acquired infections. Statistically significant differences were observed in the composition of MDRO infections among different departments ( P < 0.05). The largest proportion of specimens was obtained from sputum (59.81%), followed by wound secretions (20.77%). Sputum samples exhibited a higher proportion in community-acquired infections compared to hospital-acquired infections (63.25% vs. 38.03%, χ2 = 16.23, P < 0.05). The lower respiratory tract was identified as the primary site for community-acquired infections. Antimicrobial susceptibility testing revealed that CRAB was 100% resistant to penicillins, carbapenems, and most cephalosporins. CRPA demonstrated 100% resistance to penicillins and trimethoprim-sulfamethoxazole, but showed lower resistance rates for other antibiotics compared to CRAB and carbapenem-resistant Klebsiella pneumoniae. MRSA was 100% resistant to penicillin and cefoxitin, but exhibited a resistance rate of 0% to tigecycline and linezolid. Conclusions:In our hospital, 86.35% of MDRO infections in non-ICU departments originated from the community, primarily involving MRSA and CRPA. There were significant differences in the proportion of MDRO infections across different departments, and resistance to carbapenem antibiotics was serious. Infection prevention and control departments should implement targeted prevention strategies based on these distribution characteristics.

Objective:To analyze the clinical distribution and antibiotic resistance of multidrug-resistant organism (MDRO) infections in the non-intensive care unit (ICU) of Jiangsu Provincial (Suqian) Hospital (Suqian First Hospital), providing a basis for effective implementation of infection prevention and control measures.Methods:Using the real-time monitoring system for hospital infections, this study selected 520 strains of MDROs isolated from non-ICU hospitalized patients at Jiangsu Provincial (Suqian) Hospital (Suqian First Hospital) from January 2020 to December 2023 for analysis. Based on their origin, these strains were categorized into two groups: hospital-acquired infections and community-acquired infections. The clinical distribution characteristics of MDRO infections and their resistance rates to commonly used antimicrobial agents were analyzed.Results:The average detection rate of MDRO in non-ICU over 4 consecutive years was 13.60% (782/5 750). The detection rates for methicillin-resistant Staphylococcus aureus (MRSA), carbapenem-resistant Acinetobacter baumannii (CRAB), carbapenem-resistant Pseudomonas aeruginosa (CRPA), and carbapenem-resistant Enterobacteriaceae were 46.49% (424/912), 43.81% (85/194), 18.61% (177/951), and 2.60% (96/3 693), respectively. The predominant MDROs identified were MRSA (54.23%, 282/520) and CRPA (28.65%, 149/520). Hospital-acquired infections accounted for 13.65% (71/520), while community-acquired infections comprised 86.35% (449/520). The three departments with the highest infection rates were the Department of Respiratory (22.31%), the Department of Pediatrics (15.19%), and the Department of Traditional Chinese Medicine and Burn (7.88%). All of these departments were primarily associated with community-acquired infections. Statistically significant differences were observed in the composition of MDRO infections among different departments ( P < 0.05). The largest proportion of specimens was obtained from sputum (59.81%), followed by wound secretions (20.77%). Sputum samples exhibited a higher proportion in community-acquired infections compared to hospital-acquired infections (63.25% vs. 38.03%, χ2 = 16.23, P < 0.05). The lower respiratory tract was identified as the primary site for community-acquired infections. Antimicrobial susceptibility testing revealed that CRAB was 100% resistant to penicillins, carbapenems, and most cephalosporins. CRPA demonstrated 100% resistance to penicillins and trimethoprim-sulfamethoxazole, but showed lower resistance rates for other antibiotics compared to CRAB and carbapenem-resistant Klebsiella pneumoniae. MRSA was 100% resistant to penicillin and cefoxitin, but exhibited a resistance rate of 0% to tigecycline and linezolid. Conclusions:In our hospital, 86.35% of MDRO infections in non-ICU departments originated from the community, primarily involving MRSA and CRPA. There were significant differences in the proportion of MDRO infections across different departments, and resistance to carbapenem antibiotics was serious. Infection prevention and control departments should implement targeted prevention strategies based on these distribution characteristics.

Objective To investigate the relationship between sex hormone binding globulin (SHBG) in serum and diabetic retinopathy (DR) in patients with type 2 diabetic mellitus (T2DM).Methods A total of 160 hospitalized people with T2DM was enrolled into the study.The patients were divided into two groups with or without merged DR.Clinical and laboratorial data were collected, and the correlation was analyzed between sex hormone binding globulin and diabetic retinopathy.Results (1) Compared to the group without DR, patients in T2DM with DR had significant lower SHBG concentration, triglyceride (TG) and total cholesterol (TC) concentration were increased significantly (P ＜ 0.01).(2) The level of SHBG was associated with waist circumference, body weight, fasting blood glucose, and glycosylated hemoglobin (P ＜ 0.05).(3) While the level of SHBG was significantly increased from Quartile 1 to Quartile4, the prevalence of DR was also significantly decreased (A:70％, B:51.2％,C:40.5％, D:29.7％) (P ＜ 0.01).(4) Logistic regressing analysis shows that with the decrease of SHBG level, the increase of triglyceride levels, the risk of DR was significantly increased (SHBG:OR:0.616,95％ CI:0.447-0.850,P ＜ 0.01;TG:OR:1.323,95％ CI:1.025-1.707,P＜0.05).Conclusions With the decrease of SHBG, the prevalence of DR is significantly increased, lower SHBG may be one of the hazards of T2DM patients with DR.

Objective To investigate the relationship between with or without non?alcoholic fatty liver disease(NAFLD) and diabetic retinopathy(DR) in type 2 diabetes mellitus(T2DM)?Methods Clinical and laboratorial data of 517 cases T2DM hospitalized patients were collected,and the patients were divided into two groups according to if the NAFLD was complicated or not?Group A was T2DM with NAFLD and group B was T2DM without NAFLD?The general information and the laboratorial checking results were Compared, then various index were used as the independent variable, DR was used as the dependent variable for Logistic regression analysis?Results (1)In the 517 cases of T2DM patients,the incorporative rate of the NAFLD was 65?7%(349/517)?(2)Compared with group B,the levels of body mass index(BMI),insulin resistance index (HOMA?IR),glutamyltransferase(GGT),alanine aminotransferase(ALT),aspartate aminotransferase(AST), triglyceride(TG),total cholesterol(TC),low?density lipoprotein cholesterol(LDL?C) and uric acid(UA) for group A were significantly increased, while the high?density lipoprotein cholesterol ( HDL?C ) level was significantly decreased?All the differences were statistically significant( P<0?05)?( 3) Logistic analysis showed that the duration of the extension,hypertension,the increasing level of NAFLD,LDL?C were the risk factors of DR?Even though excluded the influence of duration,high blood pressure and LDL?C level,NAFLD was still the risk factor for T2DM complicated by the DR( OR=2?176,95% CI ( 1?354,3?199) )?Conclusion NAFLD and DR are closely related, so early diagnosis and intervention of NAFLD may prevent the occurrence and development of DR.

Adolescent ; Adult ; China ; epidemiology ; Humans ; Middle Aged ; Motor Activity ; Rural Population ; Suburban Population ; Urban Population

Objective To understand the incidence of common geriatric syndromes in hospitalized patients,and analyze the relationship between different kinds of geriatric syndromes.Methods A crosssectional study was conducted by five well-trained investigators-300 patients were chosen from geriatric department and medical department within 3 top three hospitals in Chengdu.Results 300 copies of questionnaires were distributed in total,and 300 questionnaires were returned (response rate 100％).Among those,277 questionnaires were considered valid (valid response rate 92.3％).Among those elderly which were above 65 years old,having risk of falling accounted for 91.3％,feeling pain accounted for 79.1％,chronic constipation accounted for 59.2％,having risk of malnutrition accounted for 49.1％,malnutrition accounted for 28.2％,having risk of pressure ulcers accounted for 32.5％,incontinence accounted for 25.3％,and dysphagia accounted for 17％.The correlation among these syndromes was signifcant.Conclusions The overall incidence of geriatric syndromes in hospitalized patients is higher than that in the community.These syndromes are correlated with each other.One can be a risk factor of other geriatric syndromes and also could affect each other.

Objective To understand the relationship between dietary patterns and breast cancer and to provide a possible scientific basis for breast cancer prevention,we performed a meta-analysis in order to evaluate the current relevant literature.Method Meta-analysis was used to pool the effect of vegetable,fruit,fish and soybean dietary patterns on the risk of breast cancer.The breast cancer risk of the highest categories compared to the lowest categories of such dietary patterns was combined using fixed effect model.Searching the database (Chinese databases included CQVIP,WANFANG medicine online,CNKI and SinoMED,and English databases included PubMed,Embase,Cochrane database,Medline and Google Scholar) for articles published between January 1997 and June 2014.All statistical analyses were performed using the Stata 11.0.Result Twelve cohort studies involving 623 536 participants and 19 707 patients with brcast cancer were found to be eligible.Our results indicate that a reasonably healthy dietary pattern (which is characterized by a high consumption of vegetables,fruit,fish and soybean) is beneficial for the prevention of breast cancer.Compared to the lowest categories of such dietary patterns,relative risk (RR) of the highest categories is 0.86 (95％ CI 0.80-0.92).Conclusion A reasonably healthy dietary pattern (which is characterized by a high consumption of vegetables,fruit,fish and soybean) is beneficial for the prevention of breast cancer.

Objective To explore the possible correlation between serum highly sensitive C reactive protein (hs CRP) and blood glucose, insulin, lipids ,insulin sensitivity index (SI),acute insulin response(AIR), and adiponectin in subjects with impaired glucose tolerance (IGT) or newly diagnosed type 2 diabetes mellitus(DM). Methods SI and AIR were assessed by the reduced sample number of Bergman′s minimal model method by intravenous glucose tolerance test in subjects. Meanwhile body mass index (BMI), waist hip ratio (WHR), the serum lipid profile, hs CRP, adiponectin levels were measured. Results Compared with normal control (NC) group[SI(6.6?2.4) 10 -4 (min?mU/L) -1 ,adiponectin7.77(6.35 10.70 mg/L),hs CRP0.40(0.21 1.67mg/L)], the SI and serum adiponectin in IGT group [(1.5?1.1) 10 -4 (min?mU/L) -1 , 4.29(3.59 6.22 mg/L) respectively] and type 2 DM group [(1.5?1.0)?10 -4 (min?mU/L) -1 , 3.46(2.37 4.72 mg/L) respectively] were significantly decreased (all P

Objective To identify the use of body mass index (BMI) to predict the areas under curve (AUC) of hypertension,and to find the optimal cutoff of predicting the incidences of hypertension in Chinese adults. Method Using the data from Nationwide Nutrition and Health Survey to find the new cases of four-years hypertension,and to calculate the four-year cumulative incidence (CI) of hypertension,and operate the receiver operating characteristic (ROC),analyze the AUC and calculate the sensitivity and specificity of optimal cutoff. Results Four-year CI of hypertension were 17.2% (20.3% for men and 14.2% for women),the AUC were 0.62 and 0.61 for men and women,respectively. Conclusion The optimal cut off was applicable in monitoring the incidences of hypertension,and more verification should be carried out in the future when applying this cut off.