At present, the success rate of embryo implantation is 30%-40%, of which 50%-75% of pregnancy failure originates from abnormal embryo implantation. Embryo implantation is a key link in the establishment of normal pregnancy. The main causes of embryo implantation failure are the damage of endometrial receptivity and the failure of endometrial stromal decidualization. Embryo implantation involves a range of signaling molecules and cytokines, and many studies have shown that connexin proteins are involved in the regulation of embryo implantation and endometrial decidualization. This article reviews the role of connexin in endometrial receptivity, decidualization, vascular remodeling, implantation and its regulatory mechanism, in order to provide theoretical basis for the treatment of infertility and repeated implantation failure patients, and provide new research targets for drug development.

In recent years, the rapid development of assisted reproductive technology has brought good news to infertility patients, but the current success rate of embryo implantation is low. The studies have confirmed that about 50% to 75% of pregnancy failures are due to abnormal embryo implantation. Embryo implantation is a key link in the establishment of a normal pregnancy. Impaired uterine-embryo crosstalk is the main reason for embryo implantation failure. Many studies have confirmed that extracellular vesicles (EVs), as a new method of intercellular communication, play an important role in the process of embryo implantation and can carry drugs as a potential treatment for female infertility. This article reviewed the role of EVs in preimplantation uterine-embryo crosstalk and its regulatory mechanism, in order to provide a theoretical basis for the treatment of infertility and repeated implantation failure patients.

At present, the success rate of embryo implantation is 30%-40%, of which 50%-75% of pregnancy failure originates from abnormal embryo implantation. Embryo implantation is a key link in the establishment of normal pregnancy. The main causes of embryo implantation failure are the damage of endometrial receptivity and the failure of endometrial stromal decidualization. Embryo implantation involves a range of signaling molecules and cytokines, and many studies have shown that connexin proteins are involved in the regulation of embryo implantation and endometrial decidualization. This article reviews the role of connexin in endometrial receptivity, decidualization, vascular remodeling, implantation and its regulatory mechanism, in order to provide theoretical basis for the treatment of infertility and repeated implantation failure patients, and provide new research targets for drug development.

In recent years, the rapid development of assisted reproductive technology has brought good news to infertility patients, but the current success rate of embryo implantation is low. The studies have confirmed that about 50% to 75% of pregnancy failures are due to abnormal embryo implantation. Embryo implantation is a key link in the establishment of a normal pregnancy. Impaired uterine-embryo crosstalk is the main reason for embryo implantation failure. Many studies have confirmed that extracellular vesicles (EVs), as a new method of intercellular communication, play an important role in the process of embryo implantation and can carry drugs as a potential treatment for female infertility. This article reviewed the role of EVs in preimplantation uterine-embryo crosstalk and its regulatory mechanism, in order to provide a theoretical basis for the treatment of infertility and repeated implantation failure patients.