1.A randomized controlled trial of value orientation brief therapy combined with selective serotonin reuptake inhibitors in mild to moderate depression
Ziyang JI ; Lijing SHI ; Yifang FU ; Yixuan ZHANG ; Meiqi SHAO ; Manyu HE ; Jiao DONG ; Fengju YAO ; Huiying WANG ; Changhong WANG
Chinese Mental Health Journal 2025;39(3):193-199
Objective:To evaluate the effect of value orientation brief therapy(VBT)combined with selective serotonin reuptake inhibitors(SSRIs)on clinical symptoms,rumination,decision-making ability,and cognitive func-tion in patients with mild to moderate depression.Methods:Eighty patients meeting the DSM-5 diagnostic criteria for mild to moderate depression were randomly assigned to either a medication(SSRIs)group(36 completed)or a VBT combined group(38 completed)for a 6-week intervention.Baseline and post-intervention assessments includ-ed the Hamilton Depression Scale(HAMD),Hamilton Anxious Scale(HAMA),Ruminative Response Scale-Chi-nese Version(RRS-CV),Iowa Gambling Test(IGT),number of eye fixation(NEF),responsive search score(RSS)in exploratory eye trajectory movement were used to evaluate patients'anxiety and depression symptoms,ru-minative thinking,decision-making function,and cognitive function.Results:The VBT combined group showed sig-nificantly better therapeutic effects than the medication group(P<0.05).Compared to baseline and the medication group,the VBT combined group had significantly lower post-intervention scores in HAMD,HAMA,symptom rumi-nation,introspective reflection,compulsive meditation,and RRS-CV total scores after intervention(Ps<0.05),and significantly higher scores in IGT net profit scores,NEF,and RSS scores(Ps<0.05).Compared with the medica-tion group,the VBT combined group demonstrated a greater reduction in HAMD,HAMA,symptom rumination,in-trospective reflection,compulsive meditation,and RRS-CV total scores before and after intervention(Ps<0.05),and a larger increase in IGT net profit scores,NEF,and RSS scores(Ps<0.05).Conclusion:VBT combined with SSRIs effectively improves the symptoms of depression,anxiety,decision-making ability,rumination thinking,and cognitive function in patients with mild to moderate depression.
2.A randomized controlled trial of value orientation brief therapy combined with selective serotonin reuptake inhibitors in mild to moderate depression
Ziyang JI ; Lijing SHI ; Yifang FU ; Yixuan ZHANG ; Meiqi SHAO ; Manyu HE ; Jiao DONG ; Fengju YAO ; Huiying WANG ; Changhong WANG
Chinese Mental Health Journal 2025;39(3):193-199
Objective:To evaluate the effect of value orientation brief therapy(VBT)combined with selective serotonin reuptake inhibitors(SSRIs)on clinical symptoms,rumination,decision-making ability,and cognitive func-tion in patients with mild to moderate depression.Methods:Eighty patients meeting the DSM-5 diagnostic criteria for mild to moderate depression were randomly assigned to either a medication(SSRIs)group(36 completed)or a VBT combined group(38 completed)for a 6-week intervention.Baseline and post-intervention assessments includ-ed the Hamilton Depression Scale(HAMD),Hamilton Anxious Scale(HAMA),Ruminative Response Scale-Chi-nese Version(RRS-CV),Iowa Gambling Test(IGT),number of eye fixation(NEF),responsive search score(RSS)in exploratory eye trajectory movement were used to evaluate patients'anxiety and depression symptoms,ru-minative thinking,decision-making function,and cognitive function.Results:The VBT combined group showed sig-nificantly better therapeutic effects than the medication group(P<0.05).Compared to baseline and the medication group,the VBT combined group had significantly lower post-intervention scores in HAMD,HAMA,symptom rumi-nation,introspective reflection,compulsive meditation,and RRS-CV total scores after intervention(Ps<0.05),and significantly higher scores in IGT net profit scores,NEF,and RSS scores(Ps<0.05).Compared with the medica-tion group,the VBT combined group demonstrated a greater reduction in HAMD,HAMA,symptom rumination,in-trospective reflection,compulsive meditation,and RRS-CV total scores before and after intervention(Ps<0.05),and a larger increase in IGT net profit scores,NEF,and RSS scores(Ps<0.05).Conclusion:VBT combined with SSRIs effectively improves the symptoms of depression,anxiety,decision-making ability,rumination thinking,and cognitive function in patients with mild to moderate depression.
3.A study on the current status of depression and influencing factors in older adults aged 65 and over in Henan Province
Zhengjun GUO ; Jinggui SONG ; Yujie WANG ; Jing WANG ; Jiao DONG ; Hailing WANG ; Fengju YAO ; Chuansheng WANG
Chinese Journal of Geriatrics 2022;41(7):849-854
Objective:To understand the current status of depression in older people aged 65 and over in Henan Province, and to study its influencing factors, with a focus on depression in older adults in grandparent families.Methods:A multi-stage stratified cluster sampling method was used.Baseline data about older people aged 65 and over were collected by self-designed questionnaires, the 15-item Geriatric Depression Scale(GDS-15)was used to assess depression.Results:A total of 7673 valid questionnaires about older adults aged 65 and over were collected, and the rate of depression was 29.52%(2265). Logistic regression analysis showed that 15 factors, such type of parenting, religious belief, region, degree of self-care, affected depression in older people aged 65 and above.Compared with regular parenting, grandparenting alone was a protective factor for depression[ OR(95% CI)=0.613(0.499-0.755), P<0.01]; compared with religious belief, no religious belief was a risk factor for depression[ OR(95% CI)=1.281(1.102-1.488), P<0.01]; compared with income ≥¥4000, incomes between ¥1000-1999[ OR(95% CI)=0.638(0.464-0.877), P<0.01], between ¥2000-2999[ OR(95% CI)=0.567(0.432-0.744), P<0.01]and between¥3000-3999[ OR(95% CI)=0.584(0.448-0.761), P<0.01]were protective factors for depression, with higher income showing stronger protection; compared with retirement, working had a protective effect, but the protective strength decreased in the order of working as urban labor, [ OR(95% CI)=0.332(0.273-0.405), P<0.01], as farmers[ OR(95% CI)=0.391(0.296-0.516), P<0.01], and as professionals or managers[ OR(95% CI)=0.514(0.402-0.656), P<0.01]; living in rural areas[ OR(95% CI)=0.686(0.586-0.804), P<0.01]and female[ OR(95% CI)=0.820(0.734-0.917), P<0.01]were risk factors for depression. Conclusions:There is currently a high rate of depression in older people aged 65 and over in Henan Province.Its influence factors are complicated and variable.Intervention measures taken by institutions need to adapt to specific circumstances.
4.The epidemiological survey of depressive and anxiety disorder among people aged 18 and above in Henan Province in 2021
Yujie WANG ; Changjun LIU ; Jinggui SONG ; Zhengjun GUO ; Hailing WANG ; Chuansheng WANG ; Linqi DIAO ; Fengju YAO
Chinese Journal of Psychiatry 2022;55(2):129-137
Objective:This survey aims to investigate the prevalence, distribution, and medical treatment of depressive and anxiety disorder among people aged 18 and above in Henan province.Methods:An epidemiological survey was conducted in 30 counties (cities and districts) of Henan province from November 2020 to March 2021. A total of 10 800 permanent urban and rural residents aged 18 and above were selected by the stratified multi-stage random sampling method. The Patient Health Questionnaire-9 (PHQ-9) and Generalized Anxiety Disorder Scale (GAD-7) were used for primary screening of depressive and anxiety disorders respectively. Then all participants were divided into high-, medium-, and low-risk groups based on the primary screening results. All participants in high-risk groups, 40% participants randomly selected in medium-risk groups, and 10% randomly selected in low-risk groups underwent a diagnostic procedure for depressive and anxiety disorder conducted by psychiatrists according to the 10th revision of the International Statistical Classification of Diseases and Related Health Problems (ICD-10). The adjusted prevalence, standardized prevalence, and 95 %CI were calculated based on the number of patients diagnosed with depressive or anxiety disorders in the three risk groups in 12 months. The distribution of the prevalence of two mental disorders were compared using the chi-square test and Fisher′s exact probability test. Results:Among the 10 057 participants who completed the survey, 229 were diagnosed with depressive disorder and 412 with anxiety disorder. The 12-month standardized prevalence of depressive and anxiety disorder were 1.96% (95 %CI=1.51%-2.32%) and 3.90% (95 %CI=3.57%-4.23%), respectively. The prevalence rate was higher in populations living in rural areas, aged ≥60 years old, having a lower education level, having a lower monthly income, performing less regular exercise, having chronic disease, having poor physical health, and lack of mental health literacy. The treatment rates of patients with depressive and anxiety disorders were 32.8% (75/229) and 25.5% (105/412), respectively. The main reasons for non-seeking medical services were the unawareness that poor mental health status could be a disease and the consideration that mental health problems were not serious. Conclusion:The prevalence of depressive and anxiety disorder in urban and rural residents of Henan province is lower than that in other provinces of China and the corresponding national data. These prevalence rates vary greatly among populations with different demographic characteristics. The treatment rate is still low in the current studied population.
5.The epidemiological survey of depressive and anxiety disorder among people aged 18 and above in Henan Province in 2021
Yujie WANG ; Changjun LIU ; Jinggui SONG ; Zhengjun GUO ; Hailing WANG ; Chuansheng WANG ; Linqi DIAO ; Fengju YAO
Chinese Journal of Psychiatry 2022;55(2):129-137
Objective:This survey aims to investigate the prevalence, distribution, and medical treatment of depressive and anxiety disorder among people aged 18 and above in Henan province.Methods:An epidemiological survey was conducted in 30 counties (cities and districts) of Henan province from November 2020 to March 2021. A total of 10 800 permanent urban and rural residents aged 18 and above were selected by the stratified multi-stage random sampling method. The Patient Health Questionnaire-9 (PHQ-9) and Generalized Anxiety Disorder Scale (GAD-7) were used for primary screening of depressive and anxiety disorders respectively. Then all participants were divided into high-, medium-, and low-risk groups based on the primary screening results. All participants in high-risk groups, 40% participants randomly selected in medium-risk groups, and 10% randomly selected in low-risk groups underwent a diagnostic procedure for depressive and anxiety disorder conducted by psychiatrists according to the 10th revision of the International Statistical Classification of Diseases and Related Health Problems (ICD-10). The adjusted prevalence, standardized prevalence, and 95 %CI were calculated based on the number of patients diagnosed with depressive or anxiety disorders in the three risk groups in 12 months. The distribution of the prevalence of two mental disorders were compared using the chi-square test and Fisher′s exact probability test. Results:Among the 10 057 participants who completed the survey, 229 were diagnosed with depressive disorder and 412 with anxiety disorder. The 12-month standardized prevalence of depressive and anxiety disorder were 1.96% (95 %CI=1.51%-2.32%) and 3.90% (95 %CI=3.57%-4.23%), respectively. The prevalence rate was higher in populations living in rural areas, aged ≥60 years old, having a lower education level, having a lower monthly income, performing less regular exercise, having chronic disease, having poor physical health, and lack of mental health literacy. The treatment rates of patients with depressive and anxiety disorders were 32.8% (75/229) and 25.5% (105/412), respectively. The main reasons for non-seeking medical services were the unawareness that poor mental health status could be a disease and the consideration that mental health problems were not serious. Conclusion:The prevalence of depressive and anxiety disorder in urban and rural residents of Henan province is lower than that in other provinces of China and the corresponding national data. These prevalence rates vary greatly among populations with different demographic characteristics. The treatment rate is still low in the current studied population.
6.Investigation on the effect of job-transfer training for psychiatrists in Henan province
Yujie WANG ; Shichang YANG ; Changjun LIU ; Zhengjun GUO ; Hailing WANG ; Ruiling ZHANG ; Fengju YAO
Chinese Journal of Hospital Administration 2020;36(5):422-425
Objective:To evaluate the effect of job-transfer training for psychiatrists in Henan province in 2018 and to compare them with the results of 2016.Methods:Data of the trainees were collected through questionnaires in 2017 and 2019 respectively. The influencing factors of knowledge and skills were determined by Multiple linear regression analysis; baseline data, training intention, training feedback and the proficiency of knowledge and skills were compared by independent sample t test and chi-square test. Results:The overall satisfaction rate for training was 98.3%, and the overall mastery rate of training knowledge and skills was 59.2% in year 2018. Compared with 2016, the willingness to participate in training, the satisfaction rate, the recognition degree of " 1+ 10+ 1" training mode, the degree of mastery and practical application of training knowledge and skills increased( P<0.05). There were statistically significant differences in the distribution of the primary reasons for participating in the training, factors hindering their participation in the training, and the causes for their failure to fully apply their learning to practice( P<0.01). The results showed that scope of practice, title, intention, and interest in psychiatry was related to the mastery of training knowledge and skills( P<0.05). Conclusions:The effect of training in 2018 is better than 2016, and the degree of mastery and practical application of training knowledge and skills should be increased.
7.A study on influencing factors and current status of drug compliance in patients with serious mental disorder in Henan
Zhengjun GUO ; Yujie WANG ; Changhong WANG ; Hailing WANG ; Ruiling ZHANG ; Fengju YAO
Chinese Journal of Psychiatry 2020;53(4):321-327
Objective:To understand the current status of drug compliance in patients with serious mental disorder in Henan,and to study its influencing factors.Methods:Using stratified random sampling method. The baseline data of patients were collected by self-designed questionnaires. Logistic regression analysis was conducted to determine associated factors. Independent sample t-test and chi-square test were performed to compare the baseline data of the two groups. Results:A total of 1 872 valid questionnaires were collected, and the rate of medication compliance in patients with serious mental disorder was 51.34%(961). Through multivariate logistic regression analysis, we found that 10 variables, such as relation ship, household income level, and year treatment cost were significantly associated with drug compliance. Conjugal( Wald χ2=10.491, P=0.001), and sibling relationship ( Wald χ2=10.472, P=0.001) were the risk factors for drug compliance, and it has an increased tendency. Regarding household income level, compared with the level of ‘good’, the level of ‘very good’, ‘better than good’ ( Wald χ2=4.373, P=0.037), and ‘moderate’ ( Wald χ2=4.189, P=0.041) were the protective factors for drug compliance, and it has a reducing tendency. In addition, patients′ age (45-59 years)( Wald χ2=7.060, P=0.008), living status (living together with caregivers)( Wald χ2=32.029, P<0.01), and residency (urban residents)( Wald χ2=21.908, P<0.01) were the protective factors for drug compliance. Conclusions:The current status of drug compliance in patients with serious mental disorder in Henan was rigorous, and its influence factors are complicated. The interaction between factors should be comprehensively considered before applying interventions.
8.An epidemiological survey of schizophrenia in Henan Province
Changhong WANG ; Luxian LYU ; Fengju YAO ; Ruiling ZHANG ; Weidong GUO ; Gang ZHOU ; Shuiyuan XIAO ; Lihui GUI ; Qingfeng TIAN ; Weiping ZHANG
Chinese Journal of Psychiatry 2020;53(1):23-28
Objective To investigate the morbidity rate,prevalence and influencing factors of schizophrenia among people aged 15 and above in Henan Province.Methods In 2015,a multi-stage stratified random sampling method was adopted,and the revised General Health Questionnaire (GHQ-12) was used as a preliminary screening tool to carry out mental disorder epidemiological investigation in 20 counties of Henan Province.The sampled people were divided into high,medium and low risk groups according to the GHQ-12 scores.The diagnosis of mental disorders was made by attending psychiatrist with DSM-Ⅳ-TR Axis Ⅰ diagnostic clinical interview pattern scale (SCID).The qualitative data were compared by chi-square test,and the influencing factors of schizophrenia were analyzed by Logistic regression analysis.Results A total of 23 846 people were surveyed,including 11 865 (49.76%) men and 11 981 (50.24%) women in which 124 ones were diagnosed with schizophrenia,with the adjusted lifetime prevalence rate of 5.56‰,and time point prevalence of 5.04‰.Of the 124 cases,83 lived in towns and 41 lived in cities,54 were male and 70 were female.The other basic message:level of education:illiterate 26,primary school 39,junior high school 47,high school or technical secondary school 9,junior or regular college 3;marital status:unmarried 31,first marriage 78,remarried 3,divorced 11,widowed 1.Univariate analysis showed statistically significant differences in the prevalence of schizophrenia at different levels of education (x2=33.903,P<0.01) and marital status (x2=137.143,P<0.01).Logistic regression analysis showed that urban and rural areas (Wald x2=37.296,P<0.01),gender (Wald x2=13.131,P<0.01),education level (Wald x2=48.338,P<0.01),marital status (Wald x2=54.495,P<0.01) and family history (Wald x2=107.340,P<0.01) were the influencing factors of schizophrenia.Conclusion The prevalence rate of schizophrenia in Henan Province is basically consistent with the research results at home and abroad,and the prevention and treatment of schizophrenia should be based on different regions,ages,genders,et al.
9.An epidemiological survey of schizophrenia in Henan Province
Changhong WANG ; Luxian LYU ; Fengju YAO ; Ruiling ZHANG ; Weidong GUO ; Gang ZHOU ; Shuiyuan XIAO ; Lihui GUI ; Qingfeng TIAN ; Weiping ZHANG
Chinese Journal of Psychiatry 2020;53(1):23-28
Objective To investigate the morbidity rate,prevalence and influencing factors of schizophrenia among people aged 15 and above in Henan Province.Methods In 2015,a multi-stage stratified random sampling method was adopted,and the revised General Health Questionnaire (GHQ-12) was used as a preliminary screening tool to carry out mental disorder epidemiological investigation in 20 counties of Henan Province.The sampled people were divided into high,medium and low risk groups according to the GHQ-12 scores.The diagnosis of mental disorders was made by attending psychiatrist with DSM-Ⅳ-TR Axis Ⅰ diagnostic clinical interview pattern scale (SCID).The qualitative data were compared by chi-square test,and the influencing factors of schizophrenia were analyzed by Logistic regression analysis.Results A total of 23 846 people were surveyed,including 11 865 (49.76%) men and 11 981 (50.24%) women in which 124 ones were diagnosed with schizophrenia,with the adjusted lifetime prevalence rate of 5.56‰,and time point prevalence of 5.04‰.Of the 124 cases,83 lived in towns and 41 lived in cities,54 were male and 70 were female.The other basic message:level of education:illiterate 26,primary school 39,junior high school 47,high school or technical secondary school 9,junior or regular college 3;marital status:unmarried 31,first marriage 78,remarried 3,divorced 11,widowed 1.Univariate analysis showed statistically significant differences in the prevalence of schizophrenia at different levels of education (x2=33.903,P<0.01) and marital status (x2=137.143,P<0.01).Logistic regression analysis showed that urban and rural areas (Wald x2=37.296,P<0.01),gender (Wald x2=13.131,P<0.01),education level (Wald x2=48.338,P<0.01),marital status (Wald x2=54.495,P<0.01) and family history (Wald x2=107.340,P<0.01) were the influencing factors of schizophrenia.Conclusion The prevalence rate of schizophrenia in Henan Province is basically consistent with the research results at home and abroad,and the prevention and treatment of schizophrenia should be based on different regions,ages,genders,et al.
10.A study on influencing factors and current status of drug compliance in patients with serious mental disorder in Henan
Zhengjun GUO ; Yujie WANG ; Changhong WANG ; Hailing WANG ; Ruiling ZHANG ; Fengju YAO
Chinese Journal of Psychiatry 2020;53(4):321-327
Objective:To understand the current status of drug compliance in patients with serious mental disorder in Henan,and to study its influencing factors.Methods:Using stratified random sampling method. The baseline data of patients were collected by self-designed questionnaires. Logistic regression analysis was conducted to determine associated factors. Independent sample t-test and chi-square test were performed to compare the baseline data of the two groups. Results:A total of 1 872 valid questionnaires were collected, and the rate of medication compliance in patients with serious mental disorder was 51.34%(961). Through multivariate logistic regression analysis, we found that 10 variables, such as relation ship, household income level, and year treatment cost were significantly associated with drug compliance. Conjugal( Wald χ2=10.491, P=0.001), and sibling relationship ( Wald χ2=10.472, P=0.001) were the risk factors for drug compliance, and it has an increased tendency. Regarding household income level, compared with the level of ‘good’, the level of ‘very good’, ‘better than good’ ( Wald χ2=4.373, P=0.037), and ‘moderate’ ( Wald χ2=4.189, P=0.041) were the protective factors for drug compliance, and it has a reducing tendency. In addition, patients′ age (45-59 years)( Wald χ2=7.060, P=0.008), living status (living together with caregivers)( Wald χ2=32.029, P<0.01), and residency (urban residents)( Wald χ2=21.908, P<0.01) were the protective factors for drug compliance. Conclusions:The current status of drug compliance in patients with serious mental disorder in Henan was rigorous, and its influence factors are complicated. The interaction between factors should be comprehensively considered before applying interventions.

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