Objectives:To observe the effect of teriparatide and elcatonin on the efficacy of endoscopic lum-bar interbody fusion(Endo-LIF)in patients with osteoporosis.Methods:A total of 60 patients diagnosed with lumbar spinal stenosis combined with osteoporosis undergone Endo-LIE via posterior transforaminal approach(Endo-P/TLIF)in Foshan Jianxiang Orthopedics Hospital between July 2021 and February 2023 were collect-ed.Among the patients,30 treated with vitamin D+calcium+elcatonin for 3 months after operation were included in the control group(6 males,24 females,aged 67.0±6.6 years;12 involved single segments,18 involved double segments);30 treated with teriparatide+elcatonin+vitamin 1)+calcium for 3 months after operation were included in the observation group(7 males,23 females,aged 66.0±5.9 years;10 involved single segments,20 involved double segments).There were no statistical differences in age,sex ratio,bone mineral density(BMD)before treatment and surgical segments between the two groups(P＞0.05).The visual analogue scale(VAS)score,Oswestry disability index(ODI),and systemic bone metabolism indexes[P 1NP,β-CTX,BGP,2,5(OH)VitD]were counted before and at 1 month and 3 months after treatment.The intervertebral body fusion at 3 months after treatment,and the T values of BMD before and at 6 months after treatment were also collected and evaluated.A t-test or chi-square test was applied to compare the differences between the two groups.Results:There were no statistical differences in VAS scores,ODIs,bone metabolism indexes,and T values of BMD between the two groups before treatment(P＞0.05).At 1 and 3 months after treatment,the VAS scores and ODIs were significantly reduced in both groups,with the decrease in the observation group more significantly than that in the control group at the same time point(P＜0.05).P1NP,β-CTX,BGP and 2,5(OH)VitD in the observation group were significantly higher at 1 and 3 months after treatment compared with before treatment(P＜0.05).BGP and 2,5(OH)VitD in the control group increased significantly at 3 months after treatment compared with before treatment(P＜0.05).P1NP,β-CTX and BGP were higher in the observation group than in the control group at 3 months after treatment(P＜0.05).There was no statistical difference in 2,5(OH)VitD at the same time point between the two groups(P＞0.05).The intervertebral fusion rate in the observation group was significantly higher than that of the control group at 3 months after treatment(96.66％vs 80.00％,P＜0.05).The T value of BMD in the observation group was significantly higher than in the control group at 6 months after treatment(-2.76±0.37 vs 3.06±0.42,P＜0.05).Conclusions:Teriparatide combined with elcatonin can improve the clinical symptoms,bone mineral density,and systemic bone metabolism index changes,and enhance early interbody fusion rate after Endo-P/TLIF in osteoporosis patients.

Objectives:To observe the effect of teriparatide and elcatonin on the efficacy of endoscopic lum-bar interbody fusion(Endo-LIF)in patients with osteoporosis.Methods:A total of 60 patients diagnosed with lumbar spinal stenosis combined with osteoporosis undergone Endo-LIE via posterior transforaminal approach(Endo-P/TLIF)in Foshan Jianxiang Orthopedics Hospital between July 2021 and February 2023 were collect-ed.Among the patients,30 treated with vitamin D+calcium+elcatonin for 3 months after operation were included in the control group(6 males,24 females,aged 67.0±6.6 years;12 involved single segments,18 involved double segments);30 treated with teriparatide+elcatonin+vitamin 1)+calcium for 3 months after operation were included in the observation group(7 males,23 females,aged 66.0±5.9 years;10 involved single segments,20 involved double segments).There were no statistical differences in age,sex ratio,bone mineral density(BMD)before treatment and surgical segments between the two groups(P＞0.05).The visual analogue scale(VAS)score,Oswestry disability index(ODI),and systemic bone metabolism indexes[P 1NP,β-CTX,BGP,2,5(OH)VitD]were counted before and at 1 month and 3 months after treatment.The intervertebral body fusion at 3 months after treatment,and the T values of BMD before and at 6 months after treatment were also collected and evaluated.A t-test or chi-square test was applied to compare the differences between the two groups.Results:There were no statistical differences in VAS scores,ODIs,bone metabolism indexes,and T values of BMD between the two groups before treatment(P＞0.05).At 1 and 3 months after treatment,the VAS scores and ODIs were significantly reduced in both groups,with the decrease in the observation group more significantly than that in the control group at the same time point(P＜0.05).P1NP,β-CTX,BGP and 2,5(OH)VitD in the observation group were significantly higher at 1 and 3 months after treatment compared with before treatment(P＜0.05).BGP and 2,5(OH)VitD in the control group increased significantly at 3 months after treatment compared with before treatment(P＜0.05).P1NP,β-CTX and BGP were higher in the observation group than in the control group at 3 months after treatment(P＜0.05).There was no statistical difference in 2,5(OH)VitD at the same time point between the two groups(P＞0.05).The intervertebral fusion rate in the observation group was significantly higher than that of the control group at 3 months after treatment(96.66％vs 80.00％,P＜0.05).The T value of BMD in the observation group was significantly higher than in the control group at 6 months after treatment(-2.76±0.37 vs 3.06±0.42,P＜0.05).Conclusions:Teriparatide combined with elcatonin can improve the clinical symptoms,bone mineral density,and systemic bone metabolism index changes,and enhance early interbody fusion rate after Endo-P/TLIF in osteoporosis patients.

Objective The plasma von Willebrand factor(vWF)level in patients with primary microvascular angina(PMVA)were measured to evaluate the vascular endothelial function of the patients.The change of vWF level in patients after the treatment with Shexiangbaoxin Pill were observeg.Methods Totally 69 patients who were definitely diagnosed as PMVA,They were randomly divided into conventional treatment group(33cases)and ShexiangBaoxin Pill group(36cases).The plasma vWF levels of the two groups were measured before and after treatment.Results The level of vWF before treatment in conventional treatment group was(50.93±32.98)μg/L.The level of vWF before treatment in ShexiangBaoxin Pill group was(27.45±25.02)μg/L.The level of vWF in conventional treatment group after treatment was(49.65±35.12)μg/L.The level of vWF after treatment in ShexiangBaoxin Pill group was(17.37±15.68)μg/L.The difference of vWF decrease in Baoxin Pill group after treatment(10.08±16.47)μg/L,was lower than that in conventional treatment group(1.28±12.37)μg/L,the difference is significant(P<0.05).Conclusion Shexiang Baoxin Pill has the function of protecting vascular endothelium,and PMVA patients can benefit from treatment.

Non-suicidal self-injury behavior and suicidal ideation are important risk factors for suicide attempts in patients with depression.At present,studies have found that there are obvious differences in electroencephalogram(EEG)characteristics between these two.Resting-state EEG analysis reveals that the absolute power of Gamma in specific electrode points is significantly increased in patients with depression accompanied by suicidal ideation.The Beta and Gamma activities of those with non-suicidal self-injury behavior changed.EEG microstate research shows that there are differences in microstates between those with non-suicidal self-injury behavior and those with suicidal ideation.Among them,short segments of microstate sequences have certain potential.In event-related potentials,these two show specific characteristics in components such as P3 wave and N2 wave.The amplitude of N2 wave in patients with depression accompanied by non-suicidal self-injury behavior is lower.Although there are few machine learning-related studies on EEG technology,it has shown certain application prospects.Therefore,this article will summarize the progress of EEG research related to the two,aiming to provide a basis for early prediction of suicide in depression.

BACKGROUND: Perioperative treatment has become an increasingly important aspect of the management of patients with non-small cell lung cancer (NSCLC). Small-scale clinical studies performed in recent years have shown improvements in the major pathological remission rate after neoadjuvant therapy, suggesting that it will soon become an important part of NSCLC treatment. Nevertheless, neoadjuvant immunotherapy may be accompanied by serious adverse reactions that lead to delay or cancelation of surgery, additional illness, and even death, and have therefore attracted much attention. The purpose of the clinical recommendations is to form a diagnosis and treatment plan suitable for the current domestic medical situation for the immune-related adverse event (irAE). METHODS: This recommendation is composed of experts in thoracic surgery, oncologists, thoracic medicine and irAE related departments (gastroenterology, respirology, cardiology, infectious medicine, hematology, endocrinology, rheumatology, neurology, dermatology, emergency section) to jointly complete the formulation. Experts make full reference to the irAE guidelines, large-scale clinical research data published by thoracic surgery, and the clinical experience of domestic doctors and publicly published cases, and repeated discussions in multiple disciplines to form this recommendation for perioperative irAE. RESULTS: This clinical recommendation covers the whole process of prevention, evaluation, examination, treatment and monitoring related to irAE, so as to guide the clinical work comprehensively and effectively. CONCLUSIONS Perioperative irAE management is an important part of immune perioperative treatment of lung cancer. With the continuous development of immune perioperative treatment, more research is needed in the future to optimize the diagnosis and treatment of perioperative irAE.

Objective:This article summarized the characteristics of inpatients with the COVID-19 by psychiatric contact consultation in Wuhan.Method:This was a retrospective study. A total of 105 patients consulted by the Guangdong psychological medical team from March 1, 2020 to March 7, 2020 were selected. Data were collected by 20 psychiatrists responsible for the contact consultation, including age, gender, the main reasons for the contact consultation and the psychiatric treatment plan. The consultant doctor decided whether to enter the isolation ward according to the patient′s condition introduced by the attending physician, and whom were followed up within a week. Descriptive statistical analysis was used to analyze the data.Results:There were 105 patients from 5 designated hospitals, aged （58.3±18.9） years, 62.9% (66/105) were females, and 102 (97.1%) were consulted face-to-face in the isolated ward. Main reasons for consultation were anxiety (65, 61.9%), depression (27, 25.7%), insomnia (6, 5.7%), agitation (6, 5.7%), and illusion (1, 1%). Seventy-seven of those patients (73.3%) received individualized psychotherapy, 1(1.0%) was prescribed with psychiatric medication, and 27 (25.7%) were treated with both measures. Follow-up showed that psychological symptoms relieved in 102 cases (97.1%).Conclusion:Psychosocial symptoms such as anxiety and depression are common in infected patients, and thereby psychiatric contact and consultation is in great demand in the treatment of COVID-19. Early intervention of mental health professionals in the diagnosis and treatment of patients plays a positive role in the recovery of them.

Objective:This article summarized the characteristics of inpatients with the COVID-19 by psychiatric contact consultation in Wuhan.Method:This was a retrospective study. A total of 105 patients consulted by the Guangdong psychological medical team from March 1, 2020 to March 7, 2020 were selected. Data were collected by 20 psychiatrists responsible for the contact consultation, including age, gender, the main reasons for the contact consultation and the psychiatric treatment plan. The consultant doctor decided whether to enter the isolation ward according to the patient′s condition introduced by the attending physician, and whom were followed up within a week. Descriptive statistical analysis was used to analyze the data.Results:There were 105 patients from 5 designated hospitals, aged （58.3±18.9） years, 62.9% (66/105) were females, and 102 (97.1%) were consulted face-to-face in the isolated ward. Main reasons for consultation were anxiety (65, 61.9%), depression (27, 25.7%), insomnia (6, 5.7%), agitation (6, 5.7%), and illusion (1, 1%). Seventy-seven of those patients (73.3%) received individualized psychotherapy, 1(1.0%) was prescribed with psychiatric medication, and 27 (25.7%) were treated with both measures. Follow-up showed that psychological symptoms relieved in 102 cases (97.1%).Conclusion:Psychosocial symptoms such as anxiety and depression are common in infected patients, and thereby psychiatric contact and consultation is in great demand in the treatment of COVID-19. Early intervention of mental health professionals in the diagnosis and treatment of patients plays a positive role in the recovery of them.

Objective To investigate the changes of major causes of death in patient with dermatomyositis/polymyositis (DM/PM) and the factors affecting the mortality of DM/PM in the past 28 years.Methods Death cases with DM/PM from 1985 to 2013 were retrospectively analyzed.x2 test and Fisher exact test was used for count data analysis;independent samples t-test measurement was used for data analysis;P＜0.05 was consi-dered statistically significant.Results Out of 1 443 patients with DM/PM, 74 died, in whom 48 were female and 26 were male.The mortality rate was 4.7％ among female and 6.3％ among male cases and the total in-hospital mortality of DM/PM was 5.1％.The two most common causes of death in patients with DM/PM were infection and respiratory involvement, accounting for 62.2％ (46/74) and 14.9％ (11/74) respectively.Death occurred most commonly in the first year after disease onset, accounting for 79.7％(59/74).The leading causes of death in the first year were infection and respiratory involvement.The mortality of DM/PM patients was peaked 12.3％(18/146) from 1996 to 2000;infection was the most frequent cause of death.Conclusion Infection and respiratory involvement are the main causes of death in DM/PM.Death occurrs most commonly in the first year after disease onset.

Objective To understand the pathogenic distribution and drug resistance in the patients with blood infections in our hospital to provide reference for the empirical medication of blood infections .Methods The cases of blood infections in our hospital during the period 2012-2014 were performed the retrospective investigation .The BD Bactec blood culture system was adopted to conduct the blood culture .The bacterial strain identification and susceptibility test was conducted by using the Microscan Walkaway 40 and the data were analyzed by adopting the WHONET5 .6 software .Results The top four of department distribution in blood infections were the digestive system department ,lung diseases department ,orthopedic department and surgery department ,account‐ing for 25 .20% ,19 .60% ,14 .70% and 10 .50% respectively .The pathogens were mainly Gram negative bacteria ,and the top three were Escherichia coli ,Klebsiella pneumoniae and non fermenting bacteria ,accounting for 44 .10% ,13 .30% and 7 .69% respective‐ly .The top three of Gram positive bacteria were coagulase negative staphylococci ,Staphylococcus aureus and Enterococcus ,account‐ing for 12 .58% ,9 .09% and 7 .69% respectively .The positive rates of ESBL in Escherichia coli and Klebsiella pneumoniae were 45 .5% and 60 .8% respectively .The detection rate of methicillin resistant coagulase negative staphylococci (MRCNS) was 55 .5% , which of methicillin-resistant staphylococcus aureus (MRSA) was 58 .0% .Conclusion The cases of blood infections in our hospi‐tal come from different wards areas ,and the digestive system department is in the majority mostly .The pathogenic bacteria are dom‐inated by Gram negative bacteria ,and the treatment should rationally use the antibacterial drugs according to the bacteria drug re‐sistance situation .

Objective To investigate antibiotic resistance of Pseudomonas aeruginosa isolated from the patients'specimens in the hospital ,the carrying rate of integronⅠ and insertion sequences common area(ISCR)and provide reference for clinical treatment . Methods 106 isolates of Pseudomonas aeruginosa were collected and their bacterial antibiotic resistance and clinical distribution were analyzed by using WHONET5 .6 software .PCR and electrophoresis were used to screen integronⅠ and ISCR carried by the target strains .Results Clinical isolates of Pseudomonas aeruginosa mainly collected from department of pulmonary disease which accounted for 48 .11% ,and sputum specimens were the major source of the 106 isolates ,which accounted for 73 .58% .The sensitiv‐ities of Pseudomonas aeruginosa to tobramycin ,amikacin ,gentamicin were about 85% ,while to imipenem only 65 .09% .The carry‐ing rate of integronⅠ and ISCR in Pseudomonas aeruginosa was 84 .91% and 76 .42% ,respectively .Conclusion Pseudomonas aeruginosa distribution of hospital departments mainly concentrate in pulmonary department and the major type of specimen is spu‐tum .The sensitivity of Pseudomonas aeruginosa to aminoglycoside antibiotic is relatively good .IntegronⅠand ISCR in Pseudomonas aeruginosa could be associated with antibiotic resistance .