Objective To investigate the clinical significance of beta-receptor blocker intervention on ECG changes in climac-teric women.Methods Sixty-two subjects of climacteric women without organic diseases but with ECG changes were chosen and ran-domly divided into 2 groups:the control group(n=32)and the treatment group(n=30).The subjects of the control group were not giv-en any treatment, while the subjects of the treatment group were given treatment of beta-receptor blocker intervention for 3 weeks.ECG changes ( heart rate, rhythm and ST-T changes) were detected both before and after treatment, and then, comparisons were made be-tween the groups and within the groups.Results ( 1 ) After 3 weeks of beta-receptor blocker intervention, significant ECG changes could be noted in heart rate, rhythm and ST-T changes ( except ST cable) in the subjects of the treatment group, with statistical signifi-cance, when comparisons were made between the 2 groups (P<0.05).(2)In treatment group, though changes were seen in the paired atrial premature beat ( APB) , ST cable and T wave inversion, there no statistic significance, when comparisons were made between pre and post treatment (P>0.05).There were significant changes in the remaining parameters, with statistical significance (P<0.05). Conclusion Beta-receptor blocker had its clinical value, when it was used in climacteric women with ECG changes.