TCM monomer and its compound preparation have significant effect in the treatment of breast cancer, with unique advantages of multi molecule, multi targeting, less adverse reactions, etc. TCM components such as Carthamus tinctorius polysaccharides, peimine, andrographolide, and Bupleurum saponin D can inhibit the malignant progression of breast cancer by modulating signaling pathways including PI3K/Akt, MAPK, Wnt, and JAK/STAT.