Diabetic gastroparesis （DGP） is a common diabetic neuropathy that affects the normal function of gastric motility and emptying. Clinically， it often manifests as abdominal distension， nausea and vomiting， early satiety， dyspepsia， etc. The pathogenesis of DGP is multifactorial， closely related to many factors， such as chronic hyperglycemia， neuropathy， autonomic nervous system disorders， inflammation， and oxidative stress. These factors can interact with each other， leading to delayed gastric emptying and the occurrence of related symptoms. Traditional Chinese medicine （TCM） has significant advantages in the prevention and treatment of DGP， including a long history， remarkable efficacy， individualized treatment， diverse therapeutic formulations， and improvement in the quality of life. Additionally， TCM is known for its low adverse reactions， good tolerance， and multi-targeted effects， making it an important approach in the management of DGP. Previous research has found that the main mechanisms of Chinese medicine in the prevention and treatment of DGP include the regulation of gastrointestinal hormones， inhibition of inflammatory responses， reduction of oxidative stress， enhancement of interstitial cells of Cajal activity， inhibition of pyroptosis， and modulation of related signaling pathways such as stem cell factor （SCF）/cellular growth factor receptor （c-Kit）， adenosine monophosphate-activated protein kinase （AMPK）， Ras homologous genome member A （RhoA）/Rho-associated coiled-coil forming kinase （ROCK）. This article primarily summarized the research progress on Chinese medicine in preventing and treating DGP through the inhibition of inflammatory responses， reduction of oxidative stress， enhancement of interstitial cells of Cajal activity， inhibition of pyroptosis， and regulation of related signaling pathways， aiming to provide a reference and basis for further research on the application value of Chinese medicine in the prevention and treatment of DGP.

The construction of"flagship"hospitals of the synergy of Chinese and Western medicine is promoting of quality development of public hospitals and for enhancing the status and effectiveness of integrated Chinese and Western medicines in the treatment of patients.By collecting data from 62"flagship"hospitals in China,it analyzed the current situation of the construction from the aspects of regional layout,practical experience,and practical problems,and proposed the key paths for the future high-quality development of the"flagship"hospitals of the synergy of Chinese and Western medicines in the light of the policy objectives:adhering to the leadership of Party building,constructing the evaluation index system of the"flagship"hospitals of Chinese and Western medicine collaboration,establishing a long-term safeguard mechanism through the collaboration of multiple main bodies,introducing lean management,and promoting the construction of digital intelligence.

The construction of"flagship"hospitals of the synergy of Chinese and Western medicine is promoting of quality development of public hospitals and for enhancing the status and effectiveness of integrated Chinese and Western medicines in the treatment of patients.By collecting data from 62"flagship"hospitals in China,it analyzed the current situation of the construction from the aspects of regional layout,practical experience,and practical problems,and proposed the key paths for the future high-quality development of the"flagship"hospitals of the synergy of Chinese and Western medicines in the light of the policy objectives:adhering to the leadership of Party building,constructing the evaluation index system of the"flagship"hospitals of Chinese and Western medicine collaboration,establishing a long-term safeguard mechanism through the collaboration of multiple main bodies,introducing lean management,and promoting the construction of digital intelligence.

The construction of"flagship"hospitals of the synergy of Chinese and Western medicine is promoting of quality development of public hospitals and for enhancing the status and effectiveness of integrated Chinese and Western medicines in the treatment of patients.By collecting data from 62"flagship"hospitals in China,it analyzed the current situation of the construction from the aspects of regional layout,practical experience,and practical problems,and proposed the key paths for the future high-quality development of the"flagship"hospitals of the synergy of Chinese and Western medicines in the light of the policy objectives:adhering to the leadership of Party building,constructing the evaluation index system of the"flagship"hospitals of Chinese and Western medicine collaboration,establishing a long-term safeguard mechanism through the collaboration of multiple main bodies,introducing lean management,and promoting the construction of digital intelligence.

The construction of"flagship"hospitals of the synergy of Chinese and Western medicine is promoting of quality development of public hospitals and for enhancing the status and effectiveness of integrated Chinese and Western medicines in the treatment of patients.By collecting data from 62"flagship"hospitals in China,it analyzed the current situation of the construction from the aspects of regional layout,practical experience,and practical problems,and proposed the key paths for the future high-quality development of the"flagship"hospitals of the synergy of Chinese and Western medicines in the light of the policy objectives:adhering to the leadership of Party building,constructing the evaluation index system of the"flagship"hospitals of Chinese and Western medicine collaboration,establishing a long-term safeguard mechanism through the collaboration of multiple main bodies,introducing lean management,and promoting the construction of digital intelligence.

The construction of"flagship"hospitals of the synergy of Chinese and Western medicine is promoting of quality development of public hospitals and for enhancing the status and effectiveness of integrated Chinese and Western medicines in the treatment of patients.By collecting data from 62"flagship"hospitals in China,it analyzed the current situation of the construction from the aspects of regional layout,practical experience,and practical problems,and proposed the key paths for the future high-quality development of the"flagship"hospitals of the synergy of Chinese and Western medicines in the light of the policy objectives:adhering to the leadership of Party building,constructing the evaluation index system of the"flagship"hospitals of Chinese and Western medicine collaboration,establishing a long-term safeguard mechanism through the collaboration of multiple main bodies,introducing lean management,and promoting the construction of digital intelligence.

The construction of"flagship"hospitals of the synergy of Chinese and Western medicine is promoting of quality development of public hospitals and for enhancing the status and effectiveness of integrated Chinese and Western medicines in the treatment of patients.By collecting data from 62"flagship"hospitals in China,it analyzed the current situation of the construction from the aspects of regional layout,practical experience,and practical problems,and proposed the key paths for the future high-quality development of the"flagship"hospitals of the synergy of Chinese and Western medicines in the light of the policy objectives:adhering to the leadership of Party building,constructing the evaluation index system of the"flagship"hospitals of Chinese and Western medicine collaboration,establishing a long-term safeguard mechanism through the collaboration of multiple main bodies,introducing lean management,and promoting the construction of digital intelligence.

The construction of"flagship"hospitals of the synergy of Chinese and Western medicine is promoting of quality development of public hospitals and for enhancing the status and effectiveness of integrated Chinese and Western medicines in the treatment of patients.By collecting data from 62"flagship"hospitals in China,it analyzed the current situation of the construction from the aspects of regional layout,practical experience,and practical problems,and proposed the key paths for the future high-quality development of the"flagship"hospitals of the synergy of Chinese and Western medicines in the light of the policy objectives:adhering to the leadership of Party building,constructing the evaluation index system of the"flagship"hospitals of Chinese and Western medicine collaboration,establishing a long-term safeguard mechanism through the collaboration of multiple main bodies,introducing lean management,and promoting the construction of digital intelligence.

The construction of"flagship"hospitals of the synergy of Chinese and Western medicine is promoting of quality development of public hospitals and for enhancing the status and effectiveness of integrated Chinese and Western medicines in the treatment of patients.By collecting data from 62"flagship"hospitals in China,it analyzed the current situation of the construction from the aspects of regional layout,practical experience,and practical problems,and proposed the key paths for the future high-quality development of the"flagship"hospitals of the synergy of Chinese and Western medicines in the light of the policy objectives:adhering to the leadership of Party building,constructing the evaluation index system of the"flagship"hospitals of Chinese and Western medicine collaboration,establishing a long-term safeguard mechanism through the collaboration of multiple main bodies,introducing lean management,and promoting the construction of digital intelligence.

Objective To explore the possible role of thrombospondin-1(THBS1)in the excessive fibrosis of vaginal wall induced by estrogen deficiency in rats,the morphological structure of collagen fibers and the expression of THBS1 in the vaginal wall were detected in the estrogen deficiency model of rats.Methods Twenty-four SD rats aged 3 months without delivery were randomly divided into sham operation group and experimental group,with 12 rats in each group.After 12 weeks of modeling,the rats were killed and the vaginal walls were taken for analysis.Masson staining was used to observe the morphological and structural changes of collagen fibers in vaginal wall of rats.Immunohistochemical staining and Western blotting were used to detect the expression level of THBS1 protein.Results After 12 weeks of modeling,the uterine atrophy of experimental group was obvious,the increase of body mass was significantly higher than that of sham operation group,and the level of estradiol was significantly lower than that of sham operation group(P<0.01).Compared with the sham operation group,the upper cortex of vaginal wall of experimental group was significantly atrophy,the smooth muscle bundles were thinner,the muscle gap was wider,the collagen fiber deposition in lamina propria and muscle layer was increased,and the arrangement and distribution were disordered and fragmented.THBS1 expression in vaginal wall of experimental group was significantly higher than that of sham operation group(P<0.05).Conclusion Estrogen deficiency may mediate excessive fibrosis of vaginal wall by upregulating THBS1 expression,thereby damaging the biomechanical properties of vaginal wall and leading to an increased susceptibility to pelvic organ prolapse development.