Objective To investigate the correlation between cognitive function and medication compliance in patients with type 2 diabetes mellitus(T2DM).Methods Patients with T2DM who were admitted to the Department of Endocrinology,Drum Tower Hospital,Nanjing University School of Medicine from July 2023 to December 2023 were selected.The clinical data and laboratory results of the patients were collected.The medication compliance of the patients was evaluated by Adherence to Refills and Medications Scales(ARMS).And the overall cognitive function and independent cognitive domain tests were performed.According to the diagnostic criteria of mild cognitive impairment(MCI),patients were divided into normal cognitive group and MCI group.Linear regression analysis was used to evaluate the correlation between cognitive function and medication compliance in T2DM patients.Multivariate logistic regression analysis was used to explore the relationship between cognitive dysfunction and poor medication compliance in T2DM patients.Results A total of 216 patients with T2DM were enrolled,including 113 patients with normal cognitive function and 103 patients with MCI.The ARMS score(16.4±4.1 vs.15.1±2.8)and the rate of poor medication compliance(54.4%vs.31.0%)in the MCI group were higher than those in the normal cognitive group(all P<0.05).After adjusting for gender,age,years of education and glycosylated hemoglobin,ARMS scores were significantly negatively correlated with immediate memory,attention and delayed memory scores(all P<0.05).Multivariate logistic regression analysis showed that patients with MCI had a higher risk of poor medication adherence[OR=2.645,95%CI=(1.414,4.946),P<0.001].Conclusions Poor cognitive function,especially memory and concentration,is associated with reduced medication compliance in patients with T2DM.Patients with memory and attention problems should be given appropriate medication advice to improve their compliance in clinical practice.

Adolescent idiopathic scoliosis(AIS)is a complex three-dimensional deformity involving coronal,sagittal,and axial planes,with a prevalence that should not be overlooked.With advancements in technology and in-depth research,an increasing number of hospitals and physicians are exploring standardized diagnostic and treatment approaches for AIS.Comprehensive and in-depth understanding is required for AIS,including its etiology,screening and diagnosis,classification,assessment and examination,treatment options,exploration of current focus,and evaluation of quality of life.Such understanding ensures that the diagnostic and treatment are scientific,standardized,and timely.Based on the principles of evidence-based medicine,a consensus on the diagnosis and treatment of AIS is reached after multiple discussions among spinal surgery experts,aiming to provide reference and guidance for clinical practice.

Objective We investigated the clinical features and the potential risk factors of malnutrition in patients with chronic heart failure(CHF),and constructed the risk prediction model of malnutrition.Methods A total of459 CHF patients admitted between January 2023 and July 2024 were classified into a normal nutrition group and a malnutrition group based on the geriatric Nutrition Risk Index(GNRI)score upon admission.The patient-related data were gathered,and single-variable and multi-variable logistic analyses were first carried out to identify the risk factors associated with the malnutrition risk.Subsequently,the stepwise regression approach was employed to define the inclusion criteria and construct a malnutrition nomogram model for CHF patients.The diagnostic efficacy and calibration of this model were appraised using the ROC curve and calibration curve,and its clinical utility was assessed via the clinical decision curve.A P value less than 0.05 signified statistically significant differences.Results Anxiety(OR=1.1902,95%CI:1.0217～1.3865),urea nitrogen(OR=1.4842,95%CI:1.1187～1.9691),low body weight(OR=0.8463,95%CI:0.7852～0.9121),and low albumin(OR=0.0467,95%CI:0.0172～0.1268)were risk factors for malnutrition.The optimal model inclusion factors were selected by stepwise regression,including:Body weight,7 items of Generalized Anxiety Disorder Scale(GAD-7),urea nitrogen,uric acid,albumin,total cholesterol,high density lipoprotein cholesterol(HDL-L),low density lipoprotein cholesterol(LDL-L),D-dimer.The area under the ROC curve(AUC)of the column chart model based on the above factors is 0.996(95%CI:0.971～0.978),with a sensitivity of 97.8%and a specificity of 97.1%.The C-index validated internally in the calibration curve was 0.824.The calibration chart and validation results demonstrate good consis-tency and applicability.Conclusion The column chart prediction model created in this study based on nine factors including body weight,GAD-7,urea nitrogen,uric acid,albumin,total cholesterol,HDL-L,LDL-L,and D-dimer had good calibration and prediction performance,and had good clinical practicality,which was helpful for clinicians to make diagnosis and treatment decisions for malnutrition in CHF patients.

Objective To investigate the correlation between cognitive function and medication compliance in patients with type 2 diabetes mellitus(T2DM).Methods Patients with T2DM who were admitted to the Department of Endocrinology,Drum Tower Hospital,Nanjing University School of Medicine from July 2023 to December 2023 were selected.The clinical data and laboratory results of the patients were collected.The medication compliance of the patients was evaluated by Adherence to Refills and Medications Scales(ARMS).And the overall cognitive function and independent cognitive domain tests were performed.According to the diagnostic criteria of mild cognitive impairment(MCI),patients were divided into normal cognitive group and MCI group.Linear regression analysis was used to evaluate the correlation between cognitive function and medication compliance in T2DM patients.Multivariate logistic regression analysis was used to explore the relationship between cognitive dysfunction and poor medication compliance in T2DM patients.Results A total of 216 patients with T2DM were enrolled,including 113 patients with normal cognitive function and 103 patients with MCI.The ARMS score(16.4±4.1 vs.15.1±2.8)and the rate of poor medication compliance(54.4%vs.31.0%)in the MCI group were higher than those in the normal cognitive group(all P<0.05).After adjusting for gender,age,years of education and glycosylated hemoglobin,ARMS scores were significantly negatively correlated with immediate memory,attention and delayed memory scores(all P<0.05).Multivariate logistic regression analysis showed that patients with MCI had a higher risk of poor medication adherence[OR=2.645,95%CI=(1.414,4.946),P<0.001].Conclusions Poor cognitive function,especially memory and concentration,is associated with reduced medication compliance in patients with T2DM.Patients with memory and attention problems should be given appropriate medication advice to improve their compliance in clinical practice.

Objective We investigated the clinical features and the potential risk factors of malnutrition in patients with chronic heart failure(CHF),and constructed the risk prediction model of malnutrition.Methods A total of459 CHF patients admitted between January 2023 and July 2024 were classified into a normal nutrition group and a malnutrition group based on the geriatric Nutrition Risk Index(GNRI)score upon admission.The patient-related data were gathered,and single-variable and multi-variable logistic analyses were first carried out to identify the risk factors associated with the malnutrition risk.Subsequently,the stepwise regression approach was employed to define the inclusion criteria and construct a malnutrition nomogram model for CHF patients.The diagnostic efficacy and calibration of this model were appraised using the ROC curve and calibration curve,and its clinical utility was assessed via the clinical decision curve.A P value less than 0.05 signified statistically significant differences.Results Anxiety(OR=1.1902,95%CI:1.0217～1.3865),urea nitrogen(OR=1.4842,95%CI:1.1187～1.9691),low body weight(OR=0.8463,95%CI:0.7852～0.9121),and low albumin(OR=0.0467,95%CI:0.0172～0.1268)were risk factors for malnutrition.The optimal model inclusion factors were selected by stepwise regression,including:Body weight,7 items of Generalized Anxiety Disorder Scale(GAD-7),urea nitrogen,uric acid,albumin,total cholesterol,high density lipoprotein cholesterol(HDL-L),low density lipoprotein cholesterol(LDL-L),D-dimer.The area under the ROC curve(AUC)of the column chart model based on the above factors is 0.996(95%CI:0.971～0.978),with a sensitivity of 97.8%and a specificity of 97.1%.The C-index validated internally in the calibration curve was 0.824.The calibration chart and validation results demonstrate good consis-tency and applicability.Conclusion The column chart prediction model created in this study based on nine factors including body weight,GAD-7,urea nitrogen,uric acid,albumin,total cholesterol,HDL-L,LDL-L,and D-dimer had good calibration and prediction performance,and had good clinical practicality,which was helpful for clinicians to make diagnosis and treatment decisions for malnutrition in CHF patients.

Diabetic gastroparesis （DGP） is a common diabetic neuropathy that affects the normal function of gastric motility and emptying. Clinically， it often manifests as abdominal distension， nausea and vomiting， early satiety， dyspepsia， etc. The pathogenesis of DGP is multifactorial， closely related to many factors， such as chronic hyperglycemia， neuropathy， autonomic nervous system disorders， inflammation， and oxidative stress. These factors can interact with each other， leading to delayed gastric emptying and the occurrence of related symptoms. Traditional Chinese medicine （TCM） has significant advantages in the prevention and treatment of DGP， including a long history， remarkable efficacy， individualized treatment， diverse therapeutic formulations， and improvement in the quality of life. Additionally， TCM is known for its low adverse reactions， good tolerance， and multi-targeted effects， making it an important approach in the management of DGP. Previous research has found that the main mechanisms of Chinese medicine in the prevention and treatment of DGP include the regulation of gastrointestinal hormones， inhibition of inflammatory responses， reduction of oxidative stress， enhancement of interstitial cells of Cajal activity， inhibition of pyroptosis， and modulation of related signaling pathways such as stem cell factor （SCF）/cellular growth factor receptor （c-Kit）， adenosine monophosphate-activated protein kinase （AMPK）， Ras homologous genome member A （RhoA）/Rho-associated coiled-coil forming kinase （ROCK）. This article primarily summarized the research progress on Chinese medicine in preventing and treating DGP through the inhibition of inflammatory responses， reduction of oxidative stress， enhancement of interstitial cells of Cajal activity， inhibition of pyroptosis， and regulation of related signaling pathways， aiming to provide a reference and basis for further research on the application value of Chinese medicine in the prevention and treatment of DGP.

The construction of"flagship"hospitals of the synergy of Chinese and Western medicine is promoting of quality development of public hospitals and for enhancing the status and effectiveness of integrated Chinese and Western medicines in the treatment of patients.By collecting data from 62"flagship"hospitals in China,it analyzed the current situation of the construction from the aspects of regional layout,practical experience,and practical problems,and proposed the key paths for the future high-quality development of the"flagship"hospitals of the synergy of Chinese and Western medicines in the light of the policy objectives:adhering to the leadership of Party building,constructing the evaluation index system of the"flagship"hospitals of Chinese and Western medicine collaboration,establishing a long-term safeguard mechanism through the collaboration of multiple main bodies,introducing lean management,and promoting the construction of digital intelligence.

The construction of"flagship"hospitals of the synergy of Chinese and Western medicine is promoting of quality development of public hospitals and for enhancing the status and effectiveness of integrated Chinese and Western medicines in the treatment of patients.By collecting data from 62"flagship"hospitals in China,it analyzed the current situation of the construction from the aspects of regional layout,practical experience,and practical problems,and proposed the key paths for the future high-quality development of the"flagship"hospitals of the synergy of Chinese and Western medicines in the light of the policy objectives:adhering to the leadership of Party building,constructing the evaluation index system of the"flagship"hospitals of Chinese and Western medicine collaboration,establishing a long-term safeguard mechanism through the collaboration of multiple main bodies,introducing lean management,and promoting the construction of digital intelligence.

The construction of"flagship"hospitals of the synergy of Chinese and Western medicine is promoting of quality development of public hospitals and for enhancing the status and effectiveness of integrated Chinese and Western medicines in the treatment of patients.By collecting data from 62"flagship"hospitals in China,it analyzed the current situation of the construction from the aspects of regional layout,practical experience,and practical problems,and proposed the key paths for the future high-quality development of the"flagship"hospitals of the synergy of Chinese and Western medicines in the light of the policy objectives:adhering to the leadership of Party building,constructing the evaluation index system of the"flagship"hospitals of Chinese and Western medicine collaboration,establishing a long-term safeguard mechanism through the collaboration of multiple main bodies,introducing lean management,and promoting the construction of digital intelligence.

The construction of"flagship"hospitals of the synergy of Chinese and Western medicine is promoting of quality development of public hospitals and for enhancing the status and effectiveness of integrated Chinese and Western medicines in the treatment of patients.By collecting data from 62"flagship"hospitals in China,it analyzed the current situation of the construction from the aspects of regional layout,practical experience,and practical problems,and proposed the key paths for the future high-quality development of the"flagship"hospitals of the synergy of Chinese and Western medicines in the light of the policy objectives:adhering to the leadership of Party building,constructing the evaluation index system of the"flagship"hospitals of Chinese and Western medicine collaboration,establishing a long-term safeguard mechanism through the collaboration of multiple main bodies,introducing lean management,and promoting the construction of digital intelligence.