Objective:To explore the newborn birth weight and its influencing factors of polycystic ovary syndrome (PCOS) patients during fresh embryo transfer cycle.Methods:In this retrospective cohort study, the clinical data of 5087 patients with singleton live births who underwent in vitro fertilization and embryo transfer (IVF-ET) in the Reproductive Medicine Center of the First Affiliated Hospital of Zhengzhou University from January 2014 to December 2019 were analyzed. The patients were categorized into PCOS group ( n=1095) and non-PCOS group (referred to as control group, n=3992) according to the cause of infertility. The general conditions and birth weight of the two groups were compared, and logistic regression analysis was performed to identify the factors affecting birth weight. Results:For embryo transfer on the 3rd day (day 3, D3), the clinical pregnancy rate [69.0% (1248/1808)] and the implantation rate [49.0% (1742/3555)] in PCOS group were higher than those in control group [59.1% (5661/9572) and 42.0% (7577/18 040), all P<0.001], while the live birth rate [37.0% (670/1810)] was lower than that in control group [49.0% (4697/9585), P<0.001]. For blastocyst transfer on the 5th day (day 5, D5), the implantation rate [63.1% (500/793)] and the live birth rate [54.0% (425/787)] in PCOS group were higher than those of control group [59.0% (1066/1806), P=0.042; 48.0% (876/1825), P=0.013]. The birth weight of the infants [(3 459.76±527.11) g] and the proportion of overweight infants [14.35% (61/425)] in PCOS group of D5 blastocyst transfer were higher than those in control group [(3 391.61±521.38) g, P=0.028; 8.22% (72/876), P<0.001] and PCOS group of D3 embryo transfer [(3 389.24±555.06) g, P=0.018; 9.25% (62/670), P=0.009], but the proportion of low weight infants [2.35% (10/425)] was lower than that in control group of the D5 blastocyst transfer [4.91% (43/876), P=0.029] and PCOS group of D3 embryo transfer [4.78% (32/670), P=0.042]. Logistic regression analysis showed that the level of female body mass index (BMI) affects the birth weight of D5 blastocyst transfer ( OR=1.12, 95% CI=0.052-0.175, P<0.001). Developmental timing of transferred embryos affects birth weight in PCOS patients ( OR=1.52, 95% CI=0.019-0.819, P=0.040). Conclusion:For PCOS patients, choosing D5 blastocyst transfer can obtain a higher rate of live birth and a lower proportion of low birth weight infants. It is recommended that blastocyst transfer be performed for PCOS patients in fresh cycle.

Objective:To explore the newborn birth weight and its influencing factors of polycystic ovary syndrome (PCOS) patients during fresh embryo transfer cycle.Methods:In this retrospective cohort study, the clinical data of 5087 patients with singleton live births who underwent in vitro fertilization and embryo transfer (IVF-ET) in the Reproductive Medicine Center of the First Affiliated Hospital of Zhengzhou University from January 2014 to December 2019 were analyzed. The patients were categorized into PCOS group ( n=1095) and non-PCOS group (referred to as control group, n=3992) according to the cause of infertility. The general conditions and birth weight of the two groups were compared, and logistic regression analysis was performed to identify the factors affecting birth weight. Results:For embryo transfer on the 3rd day (day 3, D3), the clinical pregnancy rate [69.0% (1248/1808)] and the implantation rate [49.0% (1742/3555)] in PCOS group were higher than those in control group [59.1% (5661/9572) and 42.0% (7577/18 040), all P<0.001], while the live birth rate [37.0% (670/1810)] was lower than that in control group [49.0% (4697/9585), P<0.001]. For blastocyst transfer on the 5th day (day 5, D5), the implantation rate [63.1% (500/793)] and the live birth rate [54.0% (425/787)] in PCOS group were higher than those of control group [59.0% (1066/1806), P=0.042; 48.0% (876/1825), P=0.013]. The birth weight of the infants [(3 459.76±527.11) g] and the proportion of overweight infants [14.35% (61/425)] in PCOS group of D5 blastocyst transfer were higher than those in control group [(3 391.61±521.38) g, P=0.028; 8.22% (72/876), P<0.001] and PCOS group of D3 embryo transfer [(3 389.24±555.06) g, P=0.018; 9.25% (62/670), P=0.009], but the proportion of low weight infants [2.35% (10/425)] was lower than that in control group of the D5 blastocyst transfer [4.91% (43/876), P=0.029] and PCOS group of D3 embryo transfer [4.78% (32/670), P=0.042]. Logistic regression analysis showed that the level of female body mass index (BMI) affects the birth weight of D5 blastocyst transfer ( OR=1.12, 95% CI=0.052-0.175, P<0.001). Developmental timing of transferred embryos affects birth weight in PCOS patients ( OR=1.52, 95% CI=0.019-0.819, P=0.040). Conclusion:For PCOS patients, choosing D5 blastocyst transfer can obtain a higher rate of live birth and a lower proportion of low birth weight infants. It is recommended that blastocyst transfer be performed for PCOS patients in fresh cycle.