Objective:Predictive modelling of risk of cancer-related cognitive impairment (CRCI) in lung cancer patients from the perspective of precision health in nursing science.Methods:Prospectively collected lung cancers treated in the Department of Respiratory Medicine of Affiliated Nanjing Brain Hospital, Nanjing Medical University from October 2023 to April 2024 as study subjects by a convenience samphing method. Lasso regression was used to screen the characteristic variables and construct the prediction model, and the predictive ability was evaluated by the AUC of the subjects′operating characteristics; Bootstrap resampling (1 000 times) internal validation of the model; the Hosmer-Lemeshow goodness-of-fit test was performed and the calibration curve was plotted to evaluate the calibration of the model; the clinical validity of the model was evaluated by decision cure analysis (DCA).Results:A total of 142 patients with lung cancer were included, 94 males and 38 females. The incidence of CRCI in lung cancer patients was 69.7%(99/142). Lasso regression showed that age(≥65), education, tumor stage, serum albumin, and PLR were independent risk factors for CRCI (coefficients of 0.372 048 72, - 0.361 265 78, 0.068 728 00, - 0.039 940 32, 0.001 639 92 respectively). The model AUC was 0.874 (95% CI: 0.815-0.933), with a sensitivity of 0.768, and a specificity of 0.860; the H-L goodness-of-fit test showed good agreement ( χ2 = 4.51, P>0.05), and Bootstrap re-sampling internal validation showed an AUC of 0.826. Calibration curves showed good agreement and accuracy between the model predicted probabilities and the actual observed probabilities. DCA showed that the model had clinical benefit when the threshold probability was approximately>25%. Conclusions:The CRCI column-line diagram risk model constructed in this study has good predictive efficacy and can effectively predict the occurrence of CRCI in lung cancer patients.

Objective:Predictive modelling of risk of cancer-related cognitive impairment (CRCI) in lung cancer patients from the perspective of precision health in nursing science.Methods:Prospectively collected lung cancers treated in the Department of Respiratory Medicine of Affiliated Nanjing Brain Hospital, Nanjing Medical University from October 2023 to April 2024 as study subjects by a convenience samphing method. Lasso regression was used to screen the characteristic variables and construct the prediction model, and the predictive ability was evaluated by the AUC of the subjects′operating characteristics; Bootstrap resampling (1 000 times) internal validation of the model; the Hosmer-Lemeshow goodness-of-fit test was performed and the calibration curve was plotted to evaluate the calibration of the model; the clinical validity of the model was evaluated by decision cure analysis (DCA).Results:A total of 142 patients with lung cancer were included, 94 males and 38 females. The incidence of CRCI in lung cancer patients was 69.7%(99/142). Lasso regression showed that age(≥65), education, tumor stage, serum albumin, and PLR were independent risk factors for CRCI (coefficients of 0.372 048 72, - 0.361 265 78, 0.068 728 00, - 0.039 940 32, 0.001 639 92 respectively). The model AUC was 0.874 (95% CI: 0.815-0.933), with a sensitivity of 0.768, and a specificity of 0.860; the H-L goodness-of-fit test showed good agreement ( χ2 = 4.51, P>0.05), and Bootstrap re-sampling internal validation showed an AUC of 0.826. Calibration curves showed good agreement and accuracy between the model predicted probabilities and the actual observed probabilities. DCA showed that the model had clinical benefit when the threshold probability was approximately>25%. Conclusions:The CRCI column-line diagram risk model constructed in this study has good predictive efficacy and can effectively predict the occurrence of CRCI in lung cancer patients.

Objective To explore EEG characteristics and the therapeutic effect in children with electrical status epilepticus during slow sleep(ESES).Methods The eligible ESES cases in our center from 2014 to 2020 were included.The age at diagnosis of ESES,the duration of ESES,spike wave index(SWI)during wakefulness and the distribution of spike wave during the period of ESES,age at seizure onset,the clinical syndromes and the outcomes after treatment were analyzed.The ESES cases were divided into 4 groups according to the distribution of spike wave:focal ESES,unilateral ESES,bilateral asymmetric ESES,multiple foci ESES.The SWI during the awake stage were divided into 3 groups based on the different rates:≤20%,21%～49%,≥50%.The therapeutic outcomes were classified into three groups:satisfactory response,seizure control and ineffective.Results 50 cases were included,with 32 males and 18 females.The average onset age of ESES was 6 years and 7 months,and the average duration of ESES was 28 months.A significant correlation between the distribution of ESES and the thera-peutic effects was found,bilateral asymmetric ESES had a good therapeutic effects,while multiple foci ESES showed a poor therapeutic effects.The duration of ESES was significantly correlated with therapeutic effects,and the efficacy was worse when the duration was longer than 1 year.A significant relationship between the SWI during wakefulness of ESES and the therapeutic effects was detected,the patient with SWI≤20%during wakefulness had a good therapeutic effect.There was a negative correlation between the onset age of ESES and the duration of ESES and SWI index during wakefulness.There was a positive correlation between the duration of ESES and SWI index during wakefulness.Conclusion Our results suggest that onset age,distribution,duration and SWI during wake-fulness of ESES were correlated with therapeutic outcomes,The patient with SWI≤20%during wakefulness had a good therapeutic effect and have unfavorable outcomes with ESES last more than 1 year.The earlier onset of ESES,the longer duration of ESES and higher SWI during wakefulness will be showed..

Ankylosing spondylitis(AS)is a typical spinal arthritis characterised by inflammatory back pain,which seriously affects the health and quality of life of patients.The clinical efficacy of Chinese medicine in the treatment of ankylosing spondylitis is clear,but the mechanism is not clear,and the existing animal models cannot be well applied to the evaluation of Chinese medicine in the treatment of ankylosing spondylitis.Therefore,this paper summarizes the existing animal models based on Chinese and Western medicine clinical diagnosis,disease characteristics,etiology and Chinese medicine evidence,and finds that among the existing animal models,the proteoglycan-induced arthritis mouse model has a higher Chinese and Western medicine clinical fit than the other models,but lacks the corresponding Chinese medicine evidence model evaluation.The other animal models had a higher Western clinical match,but lacked the characteristics of the Traditional Chinee Medicine(TCM)syndrome.As ankylosing spondylitis is a chronic inflammatory autoimmune disease with complex pathogenic factors,the existing animal models cannot better simulate the clinical symptoms.Therefore,the establishment of animal models of ankylosing spondylitis with the characteristics of Chinese and Western clinical evidence is a future research priority for AS TCM.

Inflammatory bowel disease (IBD) is a group of digestive tract diseases characterized by chronic intestinal inflammation, including ulcerative colitis and Crohn′s disease. The over-sustained immune response driven by imbalance of intestinal microbiota plays a key role in the initiation and progression of IBD. Studies have identified that intestinal microbiome possesses more than a hundred trillion types, including bacteria and fungi, which collectively participates in energy metabolism, intestinal barrier function and immune balance. There exists a stable relationship between fungi and bacteria in the intestine, involving cooperation, antagonism, and mutualism. Fungus-bacterium homeostasis plays an important role in maintaining intestinal homeostasis. Based on intestinal fungus changes in IBD patients, this article reviews the research progress in intestinal immunomodulation and therapeutic strategies derived from fungus-bacterial homeostasis.

Objective To conduct a scoping review of studies on the use of virtual reality(VR)in cancer-related cognitive impairment(CRCI),and to generalize and summarize the current state of the art of VR use in CRCI.Methods The computerized retrieval of PubMed,Embase,Web of Science,the Cochrane Library,WanFang Data,CNKI and VIP databases was carried out.Studies were collected from the database establishment to July 2023.3 researchers independently screened the literature,extracted data,and evaluated the risk of bias in the included studies.Results A total of 9 studies were included.VR was used for CRCI assessment and intervention.The assessment included visual and auditory memory,executive function and verbal fluency.The intervention content involved common cognitive impairment dimensions of CRCI,including memory,executive ability,attention,information processing speed and language fluency.The intervention frequency ranged from 3 to 5 times/week,15 to 60 min/time,and the duration was 2 to 8 weeks.The intervention frequency and intensity were dynamically adjusted based on the patient performance,game type and complexity.VR has shown good validity and benefits in CRCI assessments and interventions,while improving patients'sleep quality and ability to perform daily living,with higher patient acceptance and no VR related adverse events being reported,but its role in improving mental health remains controversial.Conclusion VR shows good validity and benefits in CRCI assessment and intervention,and has good safety and high acceptance.In the future,it is still necessary to conduct large-sample,randomized controlled studies,attach importance to the role of patient needs in the formulation of VR cognitive intervention programs,and increase CRCI-related objective indicators to further verify the effect of VR intervention on CRCI.At the same time,longitudinal evaluation and follow-up programs may be considered to determine progressive changes in CRCI from VR interventions.

Inflammatory bowel disease (IBD) is a group of digestive tract diseases characterized by chronic intestinal inflammation, including ulcerative colitis and Crohn′s disease. The over-sustained immune response driven by imbalance of intestinal microbiota plays a key role in the initiation and progression of IBD. Studies have identified that intestinal microbiome possesses more than a hundred trillion types, including bacteria and fungi, which collectively participates in energy metabolism, intestinal barrier function and immune balance. There exists a stable relationship between fungi and bacteria in the intestine, involving cooperation, antagonism, and mutualism. Fungus-bacterium homeostasis plays an important role in maintaining intestinal homeostasis. Based on intestinal fungus changes in IBD patients, this article reviews the research progress in intestinal immunomodulation and therapeutic strategies derived from fungus-bacterial homeostasis.

Objective To observe the effect of group biofeedback in patients with residual schiz-ophrenia(RS).Methods A total of 127 patients with RS were selected as study objects,and ran-domly divided into control group(n=63)and observation group(n=64).The control group re-ceived routine nursing,and the observation group received group biofeedback based on the control group.The Positive and Negative Symptom Scale(PANSS),Personal and Social Performance Scale(PSP)and Self-awareness Inventory(SAI)Questionnaire(treatment compliance)scores were com-pared between the two groups.Results After 12 weeks of intervention,the score of the positive symptoms,the score of negative symptoms and the total score of PANSS in the observation group were significantly lower than those in the control group(P＜0.05).The number of patients with PSP scores greater than 70 to 100 and greater than 30 to 70 in the observation group was significantly more than those in the control group,and the number of patients with PSP score of 0 to 30 was significantly less than that in the control group(P＜0.05).The SAI score of the observation group after interven-tion was significantly higher than that before intervention and control group,and the number of com-pleted biofeedback therapy in the observation group was significantly more than that in the control group(P＜0.05).Conclusion Group biofeedback can promote symptom relief and improve treat-ment compliance in patients with RS.

Objective To observe the effect of group biofeedback in patients with residual schiz-ophrenia(RS).Methods A total of 127 patients with RS were selected as study objects,and ran-domly divided into control group(n=63)and observation group(n=64).The control group re-ceived routine nursing,and the observation group received group biofeedback based on the control group.The Positive and Negative Symptom Scale(PANSS),Personal and Social Performance Scale(PSP)and Self-awareness Inventory(SAI)Questionnaire(treatment compliance)scores were com-pared between the two groups.Results After 12 weeks of intervention,the score of the positive symptoms,the score of negative symptoms and the total score of PANSS in the observation group were significantly lower than those in the control group(P＜0.05).The number of patients with PSP scores greater than 70 to 100 and greater than 30 to 70 in the observation group was significantly more than those in the control group,and the number of patients with PSP score of 0 to 30 was significantly less than that in the control group(P＜0.05).The SAI score of the observation group after interven-tion was significantly higher than that before intervention and control group,and the number of com-pleted biofeedback therapy in the observation group was significantly more than that in the control group(P＜0.05).Conclusion Group biofeedback can promote symptom relief and improve treat-ment compliance in patients with RS.

Patients with Crohn's disease (CD) are often complicated with malnutrition and enteral nutrition is the preferred option for nutritional support. Enteral nutrition is the first-line therapy to induce remission of CD in children, but its application in adults has not been well established. In recent years, studies have found that enteral nutrition can not only improve the nutritional status in adult CD patients, but also induce and maintain CD remission through various mechanisms. Given its favorable nutritional efficacy and safety, enteral nutrition has been considered as the basic treatment for adult CD patients and often used in combination with other treatment approaches. However, any combination therapy should be assessed in terms of benefit and risk. This review aims to describe the efficacy and safety of enteral nutrition combined with other treatment approaches in adult CD patients and enumerate common applicable clinical settings, so as to better inform clinical treatment.