Endovascular therapy (EVT) is the standard treatment for acute ischemic stroke (AIS) due to large vessel occlusion (LVO), which can effectively improve patient outcome by timely restoring cerebral blood flow perfusion. The benefits of EVT are time-dependent and significant when initiated within 6 hours of onset. The onset-to-puncture time (OPT) is divided into onset-to-door time (ODT) and door-to-puncture time (DPT). ODT is the time from symptom onset to arrival at the emergency department, reflecting the efficiency of prehospital emergency treatment; DPT is the time from emergency admission to completion of femoral artery puncture, reflecting the efficiency of in-hospital diagnosis and treatment. Despite various efforts were made in the early stage to enable 41.6% of patients with AIS who received EVT achieved a door-to-device time (DDT) of <120 min, OPT is still not ideal, and issues such as inaccurate prehospital assessments and delayed in-hospital diagnosis and treatment remain severe. This article elaborates on the impact and possible mechanisms of OPT on the outcome of patients with AIS undergoing EVT, and discusses the influencing factors and optimization strategies of OPT.

Objective To investigate the level of platelet parameter of uterine cervical cancer patients and its clinical significance. Methods Seventy-four cases with cervical cancer (the observation group) from Ningde Municipal Hospital, the Affiliated Hospital of Fujian Medical University from May 2014 to May 2016 were chosen as the research subjects. Seventy-four cases of healthy people were treated as the control group. According to the International Federation of Gynecology and Obstetrics (FIGO), the observation group was divided into 15 cases under stage ⅡB(the early stage group), 59 cases of ⅡBstage and above (the middle and advanced stage group). Platelet count (Plt) and mean volume of platelet were monitored and compared by using Japan automatic blood cell analyzer. Results Plt in the observation group was higher than that in the control group [(266 ±71) × 109/L vs. (215 ±42) × 109/L, respectively], and the difference was statistically significant (t = 5.322, P＜ 0.05). The average volume of platelet in the observation group was lower than that in the control group [(9.2±1.2) fl vs. (9.9±1.3) fl, respectively], and the difference was statistically significant (t =-3.931, P ＜ 0.05); There was no statistical difference in the Plt and mean volume of platelet between the early stage group and the middle and advanced stage group (both P＞0.05). Conclusions The determination of platelet parameter has a certain clinical significance for screening and early detection of uterine cervical cancer.