Objective To investigate the influence of Liraglutide on carotid intima-media thickness(CIMT)and serum Sirtuin protein 6(SIRT6)in patients with type 2 diabetes mellitus(T2DM)complicated with carotid atherosclerosis(CAS).Methods A total of 120 hospitalized patients with T2DM complicated with CAS were enrolled in this study from the Department of Endocrinology of Affiliated Renhe Hospital of China Three Gorges University and Yiling Hospital of Yichang City from July 2022 to January 2024.All the patients were randomly divided into Liraglutide(Lir,n=59)group and control(Con,n=61)group.Lir group was treated with Liraglutide combined with current hypoglycemic regimen.Con group was adjusted based on the original hypoglycemic scheme.The expression of serum SIRT6 and CIMT were compared between the two groups before and after treatment.Results After 24 weeks treatment,the fasting plasma glucose(FPG),2-hour postprandial blood glucose(2 hPG),glycatde hemoglobin A1c(HbA1c)and high sensitivity C-reactive protein(hs-CRP)levels were all decreased in both groups(P<0.05 or P<0.01).BMI,TC,TG,LDL-C,plasminogen activator inhibitor-1(PAI-1)and CIMT were significantly lower(P<0.05),while SIRT6 and superoxide dismutase(SOD)was significantly higher in the Lir group after treatment(P<0.05).Pearson or Spearman correlation analysis showed that CIMT was positively correlated with BMI,FPG,2 hPG,HbA1c,TC,TG,LDL-C,hs-CRP,PAI-1,DM duration(r=0.322,0.218,0.202,0.610,0.363,0.238,0.343,0.558,0.183,0.371,P<0.05 or P<0.01),and negatively correlated with SIRT6,SOD and HDL-C(r=-0.525,-0.432,-0.207,P<0.05 or P<0.01).SIRT6 was negatively correlated with BMI,HbA1c,TC,LDL-C,hs-CRP and PAI-1(r=-0.320,-0.550,-0.408,-0.422,-0.769,-0.224,P<0.05 or P<0.01),and positively correlated with SOD(r=0.550,P<0.01).Multiple stepwise regression showed that hs-CRP and SOD were independent influencing factors for SIRT6.HbA1c and SIRT6 were influencing factors for CIMT of T2DM patients.Conclusions Liraglutide could improve glucose and lipid metabolism,increase serum SIRT6 and decrease CIMT.

Objective To investigate the influence of Liraglutide on carotid intima-media thickness(CIMT)and serum Sirtuin protein 6(SIRT6)in patients with type 2 diabetes mellitus(T2DM)complicated with carotid atherosclerosis(CAS).Methods A total of 120 hospitalized patients with T2DM complicated with CAS were enrolled in this study from the Department of Endocrinology of Affiliated Renhe Hospital of China Three Gorges University and Yiling Hospital of Yichang City from July 2022 to January 2024.All the patients were randomly divided into Liraglutide(Lir,n=59)group and control(Con,n=61)group.Lir group was treated with Liraglutide combined with current hypoglycemic regimen.Con group was adjusted based on the original hypoglycemic scheme.The expression of serum SIRT6 and CIMT were compared between the two groups before and after treatment.Results After 24 weeks treatment,the fasting plasma glucose(FPG),2-hour postprandial blood glucose(2 hPG),glycatde hemoglobin A1c(HbA1c)and high sensitivity C-reactive protein(hs-CRP)levels were all decreased in both groups(P<0.05 or P<0.01).BMI,TC,TG,LDL-C,plasminogen activator inhibitor-1(PAI-1)and CIMT were significantly lower(P<0.05),while SIRT6 and superoxide dismutase(SOD)was significantly higher in the Lir group after treatment(P<0.05).Pearson or Spearman correlation analysis showed that CIMT was positively correlated with BMI,FPG,2 hPG,HbA1c,TC,TG,LDL-C,hs-CRP,PAI-1,DM duration(r=0.322,0.218,0.202,0.610,0.363,0.238,0.343,0.558,0.183,0.371,P<0.05 or P<0.01),and negatively correlated with SIRT6,SOD and HDL-C(r=-0.525,-0.432,-0.207,P<0.05 or P<0.01).SIRT6 was negatively correlated with BMI,HbA1c,TC,LDL-C,hs-CRP and PAI-1(r=-0.320,-0.550,-0.408,-0.422,-0.769,-0.224,P<0.05 or P<0.01),and positively correlated with SOD(r=0.550,P<0.01).Multiple stepwise regression showed that hs-CRP and SOD were independent influencing factors for SIRT6.HbA1c and SIRT6 were influencing factors for CIMT of T2DM patients.Conclusions Liraglutide could improve glucose and lipid metabolism,increase serum SIRT6 and decrease CIMT.

Background and purpose: Breast cancer is a group of heterogeneous diseases which has racial disparities. Our study was to elucidate the clinicopathologic features of breast carcinoma in Shanghai Han and Xinjiang Uygur women and to analyze the racial differences. Methods: In this study, 125 cases of breast invasive ductal carcinoma of Shanghai Han women and 85 cases of Xinjiang Uygur women were collected. The clinical stage was analyzed. Histological grading was observed. Immunohistochemical staining of ER, PR, HER-2, CK5/6, CK14, EGFR, Ki-67 was performed. Molecular subtypes were studied. Results:The average age of onset of breast cancer in Xinjiang Uygur women was younger than in Shanghai Han women (P<0.05), and Xinjiang Uygur women were more likely to be diagnosed at less than 35 years old (P<0.01). The proportion of stageⅠwas higher in Shanghai Han women (20.0%vs 8.2%), while the proportion of stageⅢwas higher in Xinjiang Uygur women (50.6%vs 27.2%) (P<0.01). The proportion of grade 2 was higher in Shanghai Han women (67.2% vs 43.5%), while the proportion of grade 3 was higher in Xinjiang Uygur women (47.1%vs 31.2%) (P<0.01). The proportion of luminal A subtype was higher in Shanghai Han women (36.8%vs 18.3%), while the proportion of basal-like subtype was higher in Xinjiang Uygur women (29.6%vs 12.0%) (P<0.01). The molecular subtype was associated with race and histological grade (P<0.05).Conclusion:There are racial differences in clinicopathologic features of breast carcinoma between Shanghai Han and Xinjiang Uygur women.