Iron and iron metabolism are involved in regulating the physiological functions of the female reproductive system. Essential iron plays a positive role in female development and reproductive function, while iron overload can induce abnormal metabolic processes in the body. Ferroptosis is a cellular iron-dependent disorder of lipid oxide metabolism, accompanied by oxidative imbalance and accumulation of lipid reactive oxygen species. Studies have shown that ferroptosis occurred in the pathology of endometriosis, polycystic ovary syndrome and trophoblast dysfunction diseases. Besides, the pathways and related genes of ferroptosis are involved in early embryonic development, placental oxidative stress, and regulation of oocyte function, suggesting the possibility of key molecules of iron metabolism and ferroptosis as potential therapeutic targets. The regulation mechanism for ferroptosis in female reproduction-related diseases is unclear now.This review discussed and summarized the recent research progress of iron overload and ferroptosis in female reproductive system and related diseases, in order to provide reference for clinical treatment of related diseases.

Iron and iron metabolism are involved in regulating the physiological functions of the female reproductive system. Essential iron plays a positive role in female development and reproductive function, while iron overload can induce abnormal metabolic processes in the body. Ferroptosis is a cellular iron-dependent disorder of lipid oxide metabolism, accompanied by oxidative imbalance and accumulation of lipid reactive oxygen species. Studies have shown that ferroptosis occurred in the pathology of endometriosis, polycystic ovary syndrome and trophoblast dysfunction diseases. Besides, the pathways and related genes of ferroptosis are involved in early embryonic development, placental oxidative stress, and regulation of oocyte function, suggesting the possibility of key molecules of iron metabolism and ferroptosis as potential therapeutic targets. The regulation mechanism for ferroptosis in female reproduction-related diseases is unclear now.This review discussed and summarized the recent research progress of iron overload and ferroptosis in female reproductive system and related diseases, in order to provide reference for clinical treatment of related diseases.

Cervicitis is a common infectious disease of female reproductive system. As a portal to the uterus and pelvic cavity, cervical tube has a certain protective effect. When the inflammation spreads upward, it can not only affect the normal pregnancy and cause many adverse pregnancy outcomes, such as infertility, abortion, premature birth, premature rupture of membranes and reproductive failure, but also can cause neonatal infection, even neonatal death. The clinical treatment of cervicitis can improve pregnancy, mainly about physical therapy and drug therapy, but the prognosis and potential impact of various intervention methods on female cervical infection are not the same. Therefore, it is particularly critical to adopt active and appropriate treatment. This paper discusses the effects of cervicitis and different treatment methods on pregnancy outcome and assisted reproduction technology as to provide reference for the treatment of related diseases in clinic.

Cervicitis is a common infectious disease of female reproductive system. As a portal to the uterus and pelvic cavity, cervical tube has a certain protective effect. When the inflammation spreads upward, it can not only affect the normal pregnancy and cause many adverse pregnancy outcomes, such as infertility, abortion, premature birth, premature rupture of membranes and reproductive failure, but also can cause neonatal infection, even neonatal death. The clinical treatment of cervicitis can improve pregnancy, mainly about physical therapy and drug therapy, but the prognosis and potential impact of various intervention methods on female cervical infection are not the same. Therefore, it is particularly critical to adopt active and appropriate treatment. This paper discusses the effects of cervicitis and different treatment methods on pregnancy outcome and assisted reproduction technology as to provide reference for the treatment of related diseases in clinic.