Objective To explore the effects of detecting of γ-glutamyltransferase( γ-GT)and leucine aminopeptidase(LAP)in urine on early diagnosis of kidney injury induced by zoledronic acid. Methods The patients with malignant tumor bone metastasis and received zoledronic acid from February 2012 to July 2014 in the General Hospital of Shenyang Military Command were enrolled into this study. The patient received IV infusion of zoledronic acid 4 mg,once for 25 to 35 days,finished within 30 minutes. The therapy was applied 3 times continuously. The patients' urine and venous blood samples were taken before and after each medication's morning. The levels of γ-GT,LAP in urine and serum creatinine were detected and compared. Results A total of 100 patients comprised 48 males and 52 females with a mean age of (60 ± 11)years(25-82 years)were enrolled into the study. The levels of γ-GT,LAP in urine and serum creatinine before and after receiving zoledronic acid in the first time were(8 ± 5),(7 ± 5)U/ L;(332 ± 110),(375 ± 113)nmol·s-1 ·L-1;(52 ± 12),(54 ± 12)μmol/ L,respectively. The levels of γ-GT, LAP in urine and serum creatinine before and after receiving zoledronic acid the second time were(10 ± 4), (12 ± 5)U/ L;(407 ± 104),(377 ± 126)nmol·s-1 ·L-1;(51 ± 13),(53 ± 13)μmol/ L,respectively. The levels of γ-GT,LAP in urine and serum creatinine before and after receiving zoledronic acid the third time were(16 ± 8),(19 ± 9)U/ L;(549 ± 159),(662 ± 199)nmol·s-1 ·L-1;(52 ± 15),(53 ± 14)μmol/ L,respectively. The differences of levels of γ-GT,LAP in urine before and after 3 times of medication were statistically significant( all P < 0. 05). But the differences of levels of serum creatinine were not statistically significant(all P > 0. 05). The differences of levels of γ-GT,LAP in urine after 3 times of
medication were statistically significant(all P < 0. 05). But the The differences of levels of serum creatinine were not statistically significant(all P > 0. 05). Conclusions The change in levels of γ-GT and LAP in urine was earlier than that of serum creatinine in patient with kidney injury induced by zoledronic acid. γ-GT and LAP in urine can be the early diagnostic marker of kidney injury induced by zoledronic acid.

Objective To explore the effects of detecting of γ-glutamyltransferase( γ-GT)and leucine aminopeptidase(LAP)in urine on early diagnosis of kidney injury induced by zoledronic acid. Methods The patients with malignant tumor bone metastasis and received zoledronic acid from February 2012 to July 2014 in the General Hospital of Shenyang Military Command were enrolled into this study. The patient received IV infusion of zoledronic acid 4 mg,once for 25 to 35 days,finished within 30 minutes. The therapy was applied 3 times continuously. The patients' urine and venous blood samples were taken before and after each medication's morning. The levels of γ-GT,LAP in urine and serum creatinine were detected and compared. Results A total of 100 patients comprised 48 males and 52 females with a mean age of (60 ± 11)years(25-82 years)were enrolled into the study. The levels of γ-GT,LAP in urine and serum creatinine before and after receiving zoledronic acid in the first time were(8 ± 5),(7 ± 5)U/ L;(332 ± 110),(375 ± 113)nmol·s-1 ·L-1;(52 ± 12),(54 ± 12)μmol/ L,respectively. The levels of γ-GT, LAP in urine and serum creatinine before and after receiving zoledronic acid the second time were(10 ± 4), (12 ± 5)U/ L;(407 ± 104),(377 ± 126)nmol·s-1 ·L-1;(51 ± 13),(53 ± 13)μmol/ L,respectively. The levels of γ-GT,LAP in urine and serum creatinine before and after receiving zoledronic acid the third time were(16 ± 8),(19 ± 9)U/ L;(549 ± 159),(662 ± 199)nmol·s-1 ·L-1;(52 ± 15),(53 ± 14)μmol/ L,respectively. The differences of levels of γ-GT,LAP in urine before and after 3 times of medication were statistically significant( all P < 0. 05). But the differences of levels of serum creatinine were not statistically significant(all P > 0. 05). The differences of levels of γ-GT,LAP in urine after 3 times of
medication were statistically significant(all P < 0. 05). But the The differences of levels of serum creatinine were not statistically significant(all P > 0. 05). Conclusions The change in levels of γ-GT and LAP in urine was earlier than that of serum creatinine in patient with kidney injury induced by zoledronic acid. γ-GT and LAP in urine can be the early diagnostic marker of kidney injury induced by zoledronic acid.