Objective: Endoscopic techniques are rapidly evolving, with surgery becoming much safer and less invasive. One of these procedures is lumbar interbody fusion (LIF). Although the principle of the operation is consistent among surgeons, the technique varies greatly. This study aimed to assess the clinical outcomes of Full Endoscopic Transforaminal Lumbar Interbody Fusion (e-TLIF) and report the results. Methods: In this retrospective study, data were collected from a hospital database. All patients who underwent e-TLIF from January 2022 to June 2024 were included. Results were analyzed on the basis of the visual analogue scale (VAS) for pain outcomes and the Oswestry Disability Index (ODI) for functional disability at 3 and 6 months. Results: In total, 53 patients were identified during the study period. All patients underwent full-endoscopic LIF through a posterior approach. The average hospital stay was 24 hours. The mean follow-up period was 20.9 (range, 6–36) months. Significant improvement in VAS and ODI was observed at 6 months. All patients had satisfactory outcomes. Conclusion Full-endoscopic transforaminal lumbar interbody fusion is a safe and effective procedure.