This study aimed to investigate the moderating effect of digital device use on the relationship between social exclusion and depression among older adults. Methods: A secondary data analysis was conducted using the 2020 National Survey of Older Koreans. Data from 5,656 young-old adults (aged 65~74 years) and 4,274 old-old adults (aged≥75 years) were analyzed. Descriptive statistics, chi-square tests, and hierarchical logistic regression analyses were employed. Results: Social exclusion was positively associated with depression in both age groups. Digital device use significantly moderated this relationship in the old-old group (β=-.06, p=.001), attenuating the effect of social exclusion on depression. Conclusion: These findings indicate that digital device use may serve as an effective means of alleviating and preventing depression among older adults. The results support the development of policies aimed at enhancing digital literacy for this population.

Purpose: This study aimed to assess stroke knowledge, fear of recurrence, family support, and health-promoting behavior in patients with transient ischemic attacks (TIA) and examine these factors have an effect on health-promoting behavior. Methods: A descriptive survey design was used and included 151 patients diagnosed with a TIA. Participants were recruited from a neurology outpatient clinic at a university hospital in metropolitan city B. Data were collected between February 7 and March 29, 2024, using structured questionnaires and analyzed with the IBM SPSS/WIN 27.0 program. Results: The average scores for the main variables were as follows: stroke knowledge (13.60±3.15), fear of recurrence (24.34±5.57), family support (44.40±6.02), and health-promoting behavior (65.81±6.77). Family support (β=.33, p<.001), fear of recurrence (β=.28, p<.001), and age (β=.19, p=.027) were significant predictors of health-promoting behavior, with family support showing the greatest influence. Together, these factors explained 33.0% of the variance in health-promoting behavior (F=11.72, p<.001). Conclusion These findings highlight the importance of considering the characteristics of age, addressing fear of recurrence and enhancing family support to encourage health-promoting behaviors in patients with TIA. Strengthening these areas may contribute to effective stroke prevention strategies.

Purpose: This study aimed to assess stroke knowledge, fear of recurrence, family support, and health-promoting behavior in patients with transient ischemic attacks (TIA) and examine these factors have an effect on health-promoting behavior. Methods: A descriptive survey design was used and included 151 patients diagnosed with a TIA. Participants were recruited from a neurology outpatient clinic at a university hospital in metropolitan city B. Data were collected between February 7 and March 29, 2024, using structured questionnaires and analyzed with the IBM SPSS/WIN 27.0 program. Results: The average scores for the main variables were as follows: stroke knowledge (13.60±3.15), fear of recurrence (24.34±5.57), family support (44.40±6.02), and health-promoting behavior (65.81±6.77). Family support (β=.33, p<.001), fear of recurrence (β=.28, p<.001), and age (β=.19, p=.027) were significant predictors of health-promoting behavior, with family support showing the greatest influence. Together, these factors explained 33.0% of the variance in health-promoting behavior (F=11.72, p<.001). Conclusion These findings highlight the importance of considering the characteristics of age, addressing fear of recurrence and enhancing family support to encourage health-promoting behaviors in patients with TIA. Strengthening these areas may contribute to effective stroke prevention strategies.

Purpose: This study aimed to assess stroke knowledge, fear of recurrence, family support, and health-promoting behavior in patients with transient ischemic attacks (TIA) and examine these factors have an effect on health-promoting behavior. Methods: A descriptive survey design was used and included 151 patients diagnosed with a TIA. Participants were recruited from a neurology outpatient clinic at a university hospital in metropolitan city B. Data were collected between February 7 and March 29, 2024, using structured questionnaires and analyzed with the IBM SPSS/WIN 27.0 program. Results: The average scores for the main variables were as follows: stroke knowledge (13.60±3.15), fear of recurrence (24.34±5.57), family support (44.40±6.02), and health-promoting behavior (65.81±6.77). Family support (β=.33, p<.001), fear of recurrence (β=.28, p<.001), and age (β=.19, p=.027) were significant predictors of health-promoting behavior, with family support showing the greatest influence. Together, these factors explained 33.0% of the variance in health-promoting behavior (F=11.72, p<.001). Conclusion These findings highlight the importance of considering the characteristics of age, addressing fear of recurrence and enhancing family support to encourage health-promoting behaviors in patients with TIA. Strengthening these areas may contribute to effective stroke prevention strategies.

Background: Turner syndrome (TS) is a common chromosomal abnormality, which is caused by loss of all or part of one X chromosome. Hormone replacement therapy in TS is important in terms of puberty, growth and prevention of osteoporosis however, such a study has never been conducted in Korea. Therefore, the purpose of our study was to determine relationship between the starting age, duration of estrogen replacement therapy (ERT) in TS and develop a hormone replacement protocol suitable for the situation in Korea. Methods: This is retrospective study analyzed the medical records in TS patients treated at the Severance hospital, Yonsei University College of Medicine, Seoul, Korea from 1997 to 2019. Total of 188 subjects who had received a bone density test at least once were included in the study. Korean National Health and Nutrition Examination Survey (KNHANES) was used for achieving bone mineral density (BMD) of normal control group. Student’s t-test, MannWhitney U test, ANOVA and correlation analysis were performed using SPSS 18.0. Results: Each BMD measurement was significantly lower in women with TS than in healthy Korean women. Early start and longer duration of ERT is associated with higher lumbar spine BMD but not femur neck BMD. Femur neck BMD, but not lumbar spine BMD was significantly higher in women with mosaicism than 45XO group. Conclusion Early onset and appropriate duration of hormone replacement therapy is important for increasing bone mineral density in patients with Turner syndrome. Also, ERT affects differently to TS patients according to mosaicism.

Purpose: This study aimed to assess stroke knowledge, fear of recurrence, family support, and health-promoting behavior in patients with transient ischemic attacks (TIA) and examine these factors have an effect on health-promoting behavior. Methods: A descriptive survey design was used and included 151 patients diagnosed with a TIA. Participants were recruited from a neurology outpatient clinic at a university hospital in metropolitan city B. Data were collected between February 7 and March 29, 2024, using structured questionnaires and analyzed with the IBM SPSS/WIN 27.0 program. Results: The average scores for the main variables were as follows: stroke knowledge (13.60±3.15), fear of recurrence (24.34±5.57), family support (44.40±6.02), and health-promoting behavior (65.81±6.77). Family support (β=.33, p<.001), fear of recurrence (β=.28, p<.001), and age (β=.19, p=.027) were significant predictors of health-promoting behavior, with family support showing the greatest influence. Together, these factors explained 33.0% of the variance in health-promoting behavior (F=11.72, p<.001). Conclusion These findings highlight the importance of considering the characteristics of age, addressing fear of recurrence and enhancing family support to encourage health-promoting behaviors in patients with TIA. Strengthening these areas may contribute to effective stroke prevention strategies.

Combination therapy with checkpoint inhibitors blocks inhibitory immune cell signaling and improves clinical responses to anticancer treatments. However, continued development of innovative and controllable delivery systems for immune-stimulating agents is necessary to optimize clinical responses. Herein, we engineered Salmonella to deliver recombinant granulocyte macrophage colony stimulating factor (GM-CSF) in a controllable manner for combination treatment with a programmed death-ligand 1 (PD-L1) inhibitor. The engineered Salmonella enabled delivery of recombinant GM-CSF into mouse tumors, activating recruitment of immune cells, such as M1-polarized macrophages, dendritic cells, and CD8⁺ T cells. Combination treatment with the PD-L1 inhibitor and engineered Salmonella increased the survival rate of tumor-bearing mice by 25%. New tumor growth was strongly suppressed, and visible tumors disappeared at 120 days post-infection (dpi) in mice rechallenged with additional tumor implantation at 100 dpi. The number of memory T cells increased >2-fold in tumor-rechallenged mice. Our findings demonstrate superiority of the engineered Salmonella as a cancer therapeutic agent with precise targeting ability, immune-boosting activity, and ease of combination with other therapeutics.

Objectives: This study used the Korean National Health and Nutrition Examination Survey (KNHANES) to determine the association between fractures and low muscle mass. Methods: This cross-sectional study used the 2010–2011 KNHANES data. Low muscle mass was defined as (appendicular skeletal muscle mass [kg]/Height2 [m2 ]) < 5.45 kg/m2 , which is < 2 SD below the sex-specific mean of a young reference group. Patients with T-scores between –1.0 and –2.5 indicated osteopenia, whereas those with T-scores lower than –2.5 indicated osteoporosis. Results: Out of 1,306 women enrolled in the study, 330 were diagnosed with low muscle mass according to the abovementioned diagnostic criterion. The prevalence of fractures at various sites was significantly higher in postmenopausal women with low muscle mass than in those without low muscle mass (relative risk [RR], 1.64; odds ratio [OR], 1.62; 95% confidence interval [CI], 1.06–2.48; P = 0.027). Furthermore, the prevalence of fractures was increased by the presence of osteopenia or osteoporosis in addition to low muscle mass (RR, 1.59; OR, 1.60; 95% CI, 1.02–2.49; P = 0.039) and by osteoporosis only (RR, 2.12; OR, 2.29; 95% CI, 1.11–4.70; P = 0.025). Conclusions Fracture was more prevalent in postmenopausal women with low muscle mass than in those without low muscle mass.This finding is consistent in a subgroup analysis that included women who had osteoporosis or osteopenia. Moreover, the risk of fractures increased as low muscle mass worsened.

Objective: We aimed to determine whether ovarian-preserving surgery for adnexal torsion helps preserve ovarian function without increasing the risk of postoperative complications. Methods: We retrospectively evaluated 71 women who were surgically diagnosed with adnexal torsion between January 2015 and December 2019 at Severance Hospital, Yonsei University College of Medicine (ovarian preservation group, 56; oophorectomy, 15). Serum anti-Müllerian hormone (AMH) levels measured within 6 months before surgery were compared to levels measured 6-24 months after surgery. Surgical findings and postoperative complications were compared between the groups. Results: There was a borderline significant difference in the decrease in serum AMH levels between the oophorectomy group and ovarian preservation group before and after surgery. There were no significant differences between the groups in terms of fever, infection, or duration of admission. Discoloration of the twisted ovary was found in 27.3% and 33.3% of the patients in the ovarian preservation and oophorectomy groups, respectively. There was no difference in the decrease in serum AMH levels between patients with and those without discoloration. Conclusion Ovarian-preserving surgery may not increase postoperative complications in patients with adnexal torsion, even if a twisted mass is suspected to be necrotic. Moreover, the ovarian reserve may not be affected by torsion if the ovary is preserved. Conservative ovarian surgery can be safely performed to preserve the reproductive potential of women with adnexal torsion and cystic masses.