Spinal cord infarction (SCI) is a rare but devastating complication of venoarterial extracorporeal membrane oxygenation (VA-ECMO). We report the case of a 62-year-old man who developed paraplegia with sensory deficits following VA-ECMO for septic shock. Magnetic resonance imaging demonstrated posterior spinal artery (PSA) infarction at the T11–T12 level. Electrodiagnostic studies revealed atypical findings, including absent sensory nerve action potentials and compound muscle action potentials, along with denervation of the lumbar paraspinal muscles. These abnormalities are not fully explained by PSA infarction alone and suggest the coexistence of central and peripheral mechanisms. This case illustrates a rare presentation of posterior SCI following VA-ECMO with atypical neurophysiological features and highlights the importance of multimodal evaluation for accurate diagnosis and rehabilitation planning.

Perineural (Nabors type II) cysts are typically located at the dorsal root ganglion (DRG) and are rarely reported in the cervical spine. When present, they are usually solitary and confined to the DRG level. We report a rare case of cervical perineural cysts occurring both at the DRG and proximal to the DRG within the same nerve root sleeve. A 53-year-old woman presented with intermittent left arm pain and numbness involving the left thumb, index finger, and thenar region, suggestive of C6 radiculopathy. Magnetic resonance imaging revealed a central-to-left C5-C6 disc herniation that mildly indented the ventral epidural space without significant compression of the C6 nerve root, as well as a central C6–C7 disc herniation that did not narrow the neural foramen or contact the C7 nerve root. Notably, a perineural cyst proximal to the DRG directly compressed the left C6 dorsal nerve root. Electrodiagnostic studies were normal. This case demonstrates that perineural cysts can occur proximal to the DRG and may contribute to radicular symptoms. Recognition of atypical cyst locations may improve diagnostic accuracy.

Purpose: The purpose of the study was to validate the Korean version of Patient-Reported Outcomes Measurement Information System 29 Profile v2.1 (K-PROMIS-29 V2.1) among cancer survivors. Materials and Methods: Participants were recruited from outpatient clinics of the Comprehensive Cancer Center at the Samsung Medical Center in Seoul, South Korea, from September to October 2018. Participants completed a survey questionnaire that included the K-PROMIS-29 V2.1 and the European Organisation for Research and Treatment of Cancer Quality of Life Core Questionnaire (EORTC QLQ-C30). Principal component analysis and confirmatory factor analysis (CFA) and Pearson’s correlations were used to evaluate the reliability and validity of the K-PROMIS-29 V2.1. Results: The mean age of the study participants was 54.4 years, the mean time since diagnosis was 1.2 (±2.4) years, and 349 (87.3%) completed the entire questionnaire. The Cronbach’s alpha coefficients of the seven domains in the K-PROMIS-29 V2.1 ranged from 0.81 to 0.96, indicating satisfactory internal consistency. In the CFA, the goodness-of-fit indices for the K-PROMIS-29 V2.1 were high (comparative fit index, 0.91 and standardized root-mean-squared residual, 0.06). High to moderate correlations were found between comparable subscales of the K-PROMIS-29 V2.1 and subscales of the EORTC QLQ-C30 (r=0.52-0.73). Conclusion The K-PROMIS-29 V2.1 is a reliable and valid measure for assessing the health-related quality of life domains in a cancer population, thus supporting their use in studies and oncology trials.

This study examines how acquired capability for suicide, negative urgency, and social support effectuate a suicide attempt. Sixty-three adults having visited an emergency room due to a suicide attempt were studied. The results can be summarized as follows. First, there were no significant sex differences in acquired capability for suicide, negative urgency, and social support. Second, the correlation among suicidal ideation, acquired capability for suicide, negative urgency, social support, and suicide attempts was examined. Results showed that suicide attempts were significantly and positively correlated with suicide ideation, acquired capability for suicide, and negative urgency. However, social support and suicide attempts did not significantly correlate. Third, results of hierarchical regression analysis indicated that acquired capability for suicide and negative urgency significantly predicted suicide attempts even when suicide ideation was controlled, but social support did not significantly explain attempts. In other words, study results imply that suicide attempts increase when acquired capability for suicide and negative urgency are high. Study results offer empirical data for understanding the intrinsic characteristics of individuals attempting suicide.

The current existing literature offers little guidance on how to decide which method to use to analyze one-channel microarray measurements when dealing with large, grouped samples. Most previous methods have focused on two-channel data;therefore they can not be easily applied to one-channel microarray data. Thus, a more reliable method is required to determine an appropriate combination of individual basic processing steps for a given dataset in order to improve the validity of onechannel expression data analysis. We address key issues in evaluating the effectiveness of basic statistical processing steps of microarray data that can affect the final outcome of gene expression analysis without focusingon the intrinsic data underlying biological interpretation.
Analysis of Variance ; Dataset ; Gene Expression ; Statistics as Topic

BACKGROUND: The immunologial alterations of tertian malaria are poorly understood. We investigated the hematological and immunological findings to know immunological mechanism of tertian malaria. METHODS: Forty patients with tertian malaria, hospitalized in the three affiliated hospitals of Catholic University Medical College, were enrolled in this study. The hematologic examination was performed by Coulter STKS. Atypical lymphocytes, eosinophils and plasmodium burden were counted manually. The immunoglobulin and complement concentrations were measured by nephelometry( Behring nephelometer analyzer, Germany) and automated chemiluminescence system(ACS 180, USA). The peripheral blood lymphocyte subsets were analyzed by flow cytometry using anti- CD3, CD4, CD8, CD19, CD25 and CD56 monoclonal antibodies(Becton Dickinson, San Jose, USA) and negative control. RESULTS: Anemia, lymphopenia, thrombocytopenia and eosinopenia were observed, and the eosinophil count was correlated to platelet count. The numbers of CD3+, CD8+, CD19+, CD56+, CD3-/CD56+ and CD8+/CD56+ lymphocytes were lower in tertian malaria than in control group(P<0.05). At 8th week after treatment, the percentage of CD8+ lymphocytes became significantly higher than before. The percentage of CD19+ lymphocytes was correlated to the number of eosinophils and thrombocytes(r=0.641, 0.417, P=0.000, 0.006). The serum concentrations of IgM and IgE were higher in tertian malaria than in control group. At 1st week after treatment, the IgE concentration became significantly lower than acute stage(P=0.014). The C3 and C4 concentrations were higher in tertian malaria than in control group. The C4 concentration became the same to the control group at the first week after treatment and was correlated to hemoglobin concentration. CONCLUSIONS: The eosinopenia with high IgE concentration could be a valuable marker of tertian malaria and IgE and C4 concentrations could be useful for serial monitoring after treatment.
Anemia ; Complement System Proteins ; Eosinophils ; Flow Cytometry ; Humans ; Immunoglobulin E ; Immunoglobulin M ; Immunoglobulins ; Korea* ; Luminescence ; Lymphocyte Subsets ; Lymphocytes ; Lymphopenia ; Malaria* ; Plasmodium ; Plasmodium vivax ; Platelet Count ; Thrombocytopenia