The acquired immunodeficiency syndrome patients with compromised immunity are prone to hemophagocytic syndrome secondary to opportunistic infections.This paper reports a rare case of hemophagocytic syndrome secondary to human parvovirus B19 infection in an acquired immunodeficiency syndrome patient,and analyzes the clinical characteristics,aiming to improve the diagnosis and treatment of the disease and prevent missed diagnosis and misdiagnosis.
Humans ; Lymphohistiocytosis, Hemophagocytic/drug therapy* ; Erythema Infectiosum/complications* ; Acquired Immunodeficiency Syndrome/complications* ; Parvoviridae Infections/diagnosis* ; Parvovirus B19, Human

Humans ; Erythema Infectiosum ; Lymphadenopathy

Human parvovirus B19 (B19 virus) is one of the two parvoviruses that cause human diseases. As an important pathogen to humans, it causes infectious erythema in children, acute aplastic anemia, fetal edema and death. In this review, we focus on the recent advances in the molecular virology of B19V, such as viral genotypes, viral receptor, genomic features and viral replication, viral transcription and post-transcription regulation, viral nonstructural and structural protein features and functions, viral diagnosis and antiviral agents, to provide reference for further study of B19 pathogenesis mechanisms, treatment and diagnostic strategies.
Antiviral Agents ; DNA, Viral ; genetics ; Erythema Infectiosum ; diagnosis ; virology ; Genotype ; Humans ; Parvovirus B19, Human ; genetics ; Virology ; trends ; Virus Replication

No abstract available.
Erythema Infectiosum*

Hereditary spherocytosis (HS) is a genetic disorder characterized by the production and destruction of spherocytes due to a deficiency of red cell membrane cytoskeletal proteins, resulting in the clinical presentation of chronic hemolytic anemia. This disease can be accompanied by an aplastic crisis due to parvovirus B19 infection. Parvovirus B19 infection causes diseases such as erythema infectiosum and arthritis, and can also trigger various autoimmune diseases, including autoimmune hemolytic anemia (AIHA). Here, we report a rare case of AIHA developing 3 months after an aplastic crisis due to parvovirus B19 infection in an 11-year-old boy with HS and provide the relevant literature review.
Anemia, Hemolytic ; Anemia, Hemolytic, Autoimmune ; Arthritis ; Autoimmune Diseases ; Cell Membrane ; Child ; Cytoskeletal Proteins ; Erythema Infectiosum ; Humans ; Parvovirus ; Spherocytes ; Spherocytosis, Hereditary

Hereditary spherocytosis (HS) is a genetic disorder characterized by the production and destruction of spherocytes due to a deficiency of red cell membrane cytoskeletal proteins, resulting in the clinical presentation of chronic hemolytic anemia. This disease can be accompanied by an aplastic crisis due to parvovirus B19 infection. Parvovirus B19 infection causes diseases such as erythema infectiosum and arthritis, and can also trigger various autoimmune diseases, including autoimmune hemolytic anemia (AIHA). Here, we report a rare case of AIHA developing 3 months after an aplastic crisis due to parvovirus B19 infection in an 11-year-old boy with HS and provide the relevant literature review.
Anemia, Hemolytic ; Anemia, Hemolytic, Autoimmune ; Arthritis ; Autoimmune Diseases ; Cell Membrane ; Child ; Cytoskeletal Proteins ; Erythema Infectiosum ; Humans ; Parvovirus ; Spherocytes ; Spherocytosis, Hereditary

OBJECTIVETo study the relationship between human parvovirus B19 infection and childhood idiopathic thrombocytopenic purpura (ITP) by the principle of evidence based medicine.

METHODSPapers related to the relationship between human parvovirus B19 infection and childhood ITP published between 1994 and 2008 were retrieved electronically from the Chinese Journals Full-text Database and the Wanfang Data. These relevant papers on case-control trials were statistically studied by meta analysis.

RESULTSEight papers that met the inclusion criteria were included for this meta analysis. Five hundred and sixteen cases of childhood ITP and 246 healthy controls were enrolled. The meta analysis showed that the incidence of human parvovirus B19 infection in the ITP group was significantly higher than that in the control group (OR=13.71, 95% CI=7.07-26.59, Z=7.75, p<0.01).

CONCLUSIONSHuman parvovirus B19 infection is closely associated with childhood ITP.

Child ; Erythema Infectiosum ; complications ; Female ; Humans ; Male ; Purpura, Thrombocytopenic, Idiopathic ; etiology

OBJECTIVETo characterize the risks and histopathological features of parvovirus B19 infection of infants in perinatal period.

METHODSRoutine pathological examination was performed on 1 neonate, 2 dead fetuses and 2 placentas using either autopsy or biopsy materials.

RESULTSThe diagnostic intranuclear inclusions were found in erythroblasts in the bone marrow, liver, spleen and lungs in one case, in the spleen and liver in one case, in the spleen in one case, and in the placentas in two cases.

CONCLUSIONSSevere hemolytic anemia or fetal hydrop or hemophagocytosis caused by the infection of parvovirus B19 can lead to death of infected neonates and fetus. Pathological confirmation of parvovirus B19 infection relies on the identification of erythroblasts containing the diagnostic intranuclear inclusions.

Anemia ; pathology ; virology ; Autopsy ; Biopsy ; Erythema Infectiosum ; blood ; pathology ; virology ; Erythroblasts ; ultrastructure ; Female ; Fetal Death ; Fetus ; Humans ; Hydrops Fetalis ; pathology ; virology ; Inclusion Bodies ; ultrastructure ; Infant, Newborn ; Lymphohistiocytosis, Hemophagocytic ; pathology ; virology ; Parvovirus B19, Human ; isolation & purification ; Placenta ; pathology ; virology ; Pregnancy ; Stillbirth

Parvovirus B19 has been recently identified as the cause of various diseases such as erythema infectiosum, transient aplastic crisis in patients with chronic hemolytic anemias, hydrops fetalis, bone marrow suppression in immunocompromised hosts, and lastly acute and chronic arthropathy mimicking rheumatoid arthritis (RA) and occasionally, systemic lupus erythematosus (SLE). We describe a female patient who presented with fever, chills, polyarthralgia, serologic and PCR evidence of presence of Parvovirus B19, and expression of antinuclear antibody, anti- Ro/SSA and anti-La/SSB. There has been no clinical findings suggestive or diagnostic of any diffuse connective tissue diseases in this patient. Although there has been reports of Parvovirus B19 infection mimicking RA and SLE with manifestations of various autoimmune antibodies including rheumatoid factor, antinuclear antibody, anti-dsDNA, antilymphocyte antibody, and antiphospholipid antibody, there has not been any report of anti-Ro/SSA and anti-La/SSB expression in the setting of parvoviral arthropathy and this is the first case report.
Anemia, Hemolytic ; Antibodies ; Antibodies, Antinuclear* ; Antibodies, Antiphospholipid ; Antilymphocyte Serum ; Arthralgia ; Arthritis, Rheumatoid ; Bone Marrow ; Chills ; Connective Tissue Diseases ; Erythema Infectiosum ; Female ; Fever ; Humans ; Hydrops Fetalis ; Immunocompromised Host ; Lupus Erythematosus, Systemic ; Parvovirus* ; Polymerase Chain Reaction ; Rheumatoid Factor

Human parvovirus(HPV) B19 infection causes erythema infectiosum in children, sometimes red cell aplastic crisis with hemolytic anemia and chronic bone marrow failure in immunocompromised hosts. HPV B19 is directly cytotoxic for erythroid progenitor cells and inhibits erythropoiesis. Infrequently, HPV B19 inhibits hematopoiesis of three cell lineages and causes transient pancytopenia in patients with hemolytic disorders. We report three patients with hereditary spherocytosis who developed transient aplastic crisis. A HPV B19 infection was confirmed by IgM anti-B19 parvovirus titers and characteristic findings of bone marrow examination as the causative agent associated with severe pancytopenia. Three patients recovered spontaneously after a short period of supportive care with red cell transfusions and intravenous immunoglobulin.
Anemia, Hemolytic ; Bone Marrow ; Bone Marrow Examination ; Cell Lineage ; Child ; Erythema Infectiosum ; Erythroid Precursor Cells ; Erythropoiesis ; Hematopoiesis ; Humans ; Immunocompromised Host ; Immunoglobulin M ; Immunoglobulins ; Pancytopenia ; Parvovirus*