VALIDATION AND RELIABILITY OF A GUIDED QUESTIONNAIRE (GQ) FOR TYPE 1 DIABETES MELLITUS (T1DM) CHILDREN AND PARENTS ON PERIODONTAL DISEASE (PD) The prevalence of PD is notably high in individuals with T1DM. Despite this, there is a limited availability of research on the utilization of questionnaires to evaluate self-perceived PD, patient knowledge, and their perception of PD in T1DM patients. Therefore, our objective was to establish validity and reliability of a bilingual (English-Malay) version of the guided questionnaire (GQ) to be used among pediatric T1DM patients attending Universiti Teknologi MARA (UiTM) Sungai Buloh campus and the Universiti Malaya (UM). This questionnaire focused on self-reported periodontal disease (PD), assessing their knowledge, and understanding of the bidirectional relationship between PD and T1DM. The dual-language GQ was adapted from the Self-Reported Questionnaire Malay Modified (SRQMM) to suit the targeted participants. Content validation was carried out among five field experts, and face validation was done among pediatric patients in Dental Faculty UiTM. Reliability testing was administered in T1DM patients attending UiTM and UM. The structure and words of the component in GQ were modified to ensure that it was appropriate for the participants. The item-level Content Validity Index (I-CVI) turned out to be valid with an average of 0.98. The subjective measurement of face validation showed satisfactory results after the second revision. Reliability concerning Cronbach’s alpha (α) values was computed relying on all 21 items, which were acceptable at about 0.777, 0.644, 0.780 in the self-perceived PD assessment domain, knowledge domain and perception domain, respectively. Hence, the adapted dual language paediatrics version of the GQ is a reliable and valid tool for assessing self-perceived PD, knowledge, and perception in T1DM patients on PD and it can be effectively utilized by non-dental healthcare personnel.

ORAL HEALTH DISPARITIES AMONG CHILDREN WITH AUTISM SPECTRUM DISORDER AND TYPICALLY DEVELOPING PEERS: A CASE-CONTROL STUDY AT UNIVERSITI TEKNOLOGI MARA Children diagnosed with autism spectrum disorder (ASD) may not manifest distinct oral characteristics related to ASD, yet the disorder itself could impact their oral health. This case-control study aimed to assess and compare oral hygiene, dental caries, and periodontal status between children with and without ASD. Twenty-eight children with ASD and thirty without ASD (aged 3 to 16 years) attending the paediatric dentistry clinic at UiTM, Sungai Buloh campus, underwent clinical oral examinations. Parameters included Modified Gingival Index (MGI), simplified Basic Periodontal Examination (sBPE), Oral Hygiene-Simplified Index (OHI-S), DMFT, and dmft scores. Chi-square and independent t test were used to compare the two groups. p values < 0.05 were considered statistically significant. Children with ASD showed a higher prevalence of poor oral hygiene (3.6%) compared to those without ASD (0.0%). MGI indicated a higher percentage of moderate inflammation in children with ASD (3.6%). sBPE revealed higher rates of bleeding on probing (67.9%) and calculus deposits (28.6%) in children with ASD compared to those without ASD (60.0% and 20.0%, respectively). Children with ASD showed a higher mean (SD) DMFT of 1.57 (3.9) compared to those without ASD, 0.83 (1.67), and children without ASD had a higher mean (SD) dmft of 5.87 (5.78) in contrast to children with ASD, 4.5 (5.45). These differences did not reach statistical significance. Despite the numerical variations, it was not statistically confirmed that children with ASD are at a significantly higher risk of dental caries and periodontal diseases. Early detection of risk factors for these conditions in children with ASD is crucial for preventive interventions.

ABSTRACT Various grafting materials are utilised to facilitate regeneration. There is currently a paradigm shift towards applying poly lactic-co-glycolic acid (PLGA), which is regarded as an excellent scaffold for tissue engineering. Concentrated growth factor (CGF) has also been reported to promote wound healing. Nevertheless, the role of PLGA microspheres as a substitute for bone graft material with CGF in bone regeneration remains unclear. This study was designed to evaluate the effect of CGF with PLGA on bone formation and the expression of alkaline phosphatase (ALP) following socket preservation. PLGA microspheres were prepared using double solvent evaporation method and observed under scanning electron microscopy (SEM). A 6 mL of rabbit’s blood was collected from the marginal ear vein and centrifuged to obtain CGF. Blood was also collected for ALP assessment from 24 New Zealand White (NZW) male rabbits subjected to the first upper left premolar extraction. Sockets were filled with CGF, PLGA, CGF+PLGA or left empty and observed with microscopic computed tomography (micro-CT) at four weeks and eight weeks. The SEM image revealed a spherical shape with interconnected pores on the surface of the PLGA particles. Repeated measures ANOVA were used to evaluate the effect of time and treatment (p < 0.05) with significant differences in bone width, height, volume, volume fraction and expression of ALP was observed with CGF+PLGA. Both CGF and PLGA have the potential as the alternative grafting materials and this study could serve as an ideal benchmark for future investigations on the role of CGF+PLGA in bone regeneration enhancement.
Bone Regeneration ; Platelet-Derived Growth Factor ; Polylactic Acid-Polyglycolic Acid Copolymer

ABSTRACT Implant periapical lesion (IPL) is also known as retrograde peri-implantitis and as the name suggests, it involves inflammation surrounding the apical part of the dental implants. Previously, many studies have reported the event of IPL that further delays osseointegration, and some reported failure of implant placement due to this disease. In this article, we described two cases of early dental implant failure that was associated with active IPL and correlated the clinical and radiographical findings with the histopathological findings.
Dental Restoration Failure ; Dental Implants--adverse effects ; Periapical Tissue

The vast range of treatment protocols available for non-surgical management of chronic periodontitis can affect the consistency of clinical decision-making for dentists. This is further compounded by the different case definitions for periodontitis used in various clinical studies. The aim of this paper is to describe the steps taken leading to an expert consensus of periodontitis case definition followed by the development of a clinical pathway for managing chronic periodontitis. To assist reaching a consensus on a standard case definition of periodontitis for clinical research, a roundtable discussion was held involving 13 dental specialists and researchers from universities and the Ministry of Health. Participants discussed clinical experiences in identifying periodontitis and related issues based on scientific evidence. A further expert panel discussion consisting of 8 periodontists was conducted at another session to review current management practices and evidence-based practices available from the literature and generated a clinical pathway for non-surgical management of periodontitis. The case definition derived from the roundtable discussion recognises differentiation of selected clinical parameters and their thresholds as well as the extent and severity of the periodontitis. As for the newly developed clinical pathway, experts collectively defined the appropriate goals to satisfy the multidimensional needs of the patients which are translated into detailed elements of care, including the sequence of events of patients at each dental visit over time. The agreed case definition will facilitate selection and recruitment of cases for clinical studies while the clinical pathway can be used to reduce variations between clinicians.

The vast range of treatment protocols available for non-surgical management of chronic periodontitis can affect the consistency of clinical decision-making for dentists. This is further compounded by the different case definitions for periodontitis used in various clinical studies. The aim of this paper is to describe the steps taken leading to an expert consensus of periodontitis case definition followed by the development of a clinical pathway for managing chronic periodontitis. To assist reaching a consensus on a standard case definition of periodontitis for clinical research, a roundtable discussion was held involving 13 dental specialists and researchers from universities and the Ministry of Health. Participants discussed clinical experiences in identifying periodontitis and related issues based on scientific evidence. A further expert panel discussion consisting of 8 periodontists was conducted at another session to review current management practices and evidence-based practices available from the literature and generated a clinical pathway for non-surgical management of periodontitis. The case definition derived from the roundtable discussion recognises differentiation of selected clinical parameters and their thresholds as well as the extent and severity of the periodontitis. As for the newly developed clinical pathway, experts collectively defined the appropriate goals to satisfy the multidimensional needs of the patients which are translated into detailed elements of care, including the sequence of events of patients at each dental visit over time. The agreed case definition will facilitate selection and recruitment of cases for clinical studies while the clinical pathway can be used to reduce variations between clinicians.
Case definitions ; clinical pathway ; periodontitis