Objective To investigate the effectiveness of Multimodal image fusion and 3D reconstruction techniques in the surgical treatment of posterior cranial fossa tumours surgery.Methods Retrospective analysis of medical records of 19 patients with posterior cranial fossa tumours who underwent surgical treatment between January 2022 and September 2023 in Department of Neurosurgery,the Affiliated People's Hospital of Jiangsu University.All patients underwent preoperative CT and MR imaging of the head,and these image data were input into an image fusion workstation for image fusion and 3D reconstruction.The surgeon then used these fused images for spatial assessment of the tumour and simulation of surgical access.Results The multimodal image fusion techniques could clearly show the anatomical relationship between the tumour of the posterior cranial fossa and the surrounding structures,and there were 15 cases of total resection of the tumour in 19 patients(78.9％),4 cases of subtotal resection,and no perioperative death patients.Postoperative complications included cerebral oedema in 2 cases,intracranial infection in 1 case,facial paralysis in 2 cases,and dysphagia in 1 case.According to the feedback from the surgeons,the multimodal image fusion techniques showed significant value in surgery in 16 cases and ancillary value in 3 cases.Conclusion Multimodal image fusion technology and 3D reconstruction techniques in can accurately and clearly show the spatial relationship between the tumour in the posterior cranial fossa and the surrounding important tissues,which helps the surgeon to more accurately design the surgical incision and choose a more reasonable surgical approach.It has a high auxiliary value for the successful completion of surgery.

Objective:The composition of thrombi obtained during mechanical thrombectomy in patients with acute ischemic stroke is analyzed to investigate its relation with stroke etiology and its influence in surgical parameters and clinical prognoses.Methods:The thrombi and clinical data of 41 patients with acute ischemic stroke directly treated by mechanical thrombectomy in our hospital from January 2019 to December 2019 were collected. Hematoxylin-eosin (HE) staining was used to quantitatively analyze the composition of thrombi, and the components of thrombi in patients with different causes of stroke (large artery atherosclerosis [LAA], cardiogenic embolism [CE], and unexplained type) were compared. These patients were divided into erythrocyte-rich group (erythrocyte content>fibrin content) and fibrin-rich group (erythrocyte content0.05). Conclusion:Thrombus composition has influence in surgical parameters, but no influence in clinical prognoses.

A 4-month-old premature infant with broncho-pulmonary dysplasia was hospitalized and received imipenem and cilastatin sodium combined with erythromycin for severe pneumonia. During hospitalization, erythromycin was stopped because of exacerbation of infection and replaced by vancomycin hydrochloride 60 mg dissolved in 5% glucose injection 15 ml by an IV infusion at a speed of 60 mg/h. About 10 minutes of vancomycin treatment, the infant developed cry and noisy and facial flushing. Then the infusion speed was slowed down, but the infant was still crying and his skin erythema increased, which gradually fused into pieces on his neck, chest and limbs. And his heart rate increased to 160 beats/min. Red man syndrome induced by vancomycin was considered. Vancomycin was stopped immediately and no antiallergic agents were given. About one hour later, the skin rash disappeared gradually and the heart rate decreased to 140 beats/min. The next day, the skin color returned to normal. Then teicoplanin combined with imipenem and cilastatin sodium were given according to the results of drug sensitivity test in sputum culture. The rash did not recur. Two weeks later, his pneumonia improved and he was discharged.

A 4-month-old premature infant with broncho-pulmonary dysplasia was hospitalized and received imipenem and cilastatin sodium combined with erythromycin for severe pneumonia. During hospitalization, erythromycin was stopped because of exacerbation of infection and replaced by vancomycin hydrochloride 60 mg dissolved in 5% glucose injection 15 ml by an IV infusion at a speed of 60 mg/h. About 10 minutes of vancomycin treatment, the infant developed cry and noisy and facial flushing. Then the infusion speed was slowed down, but the infant was still crying and his skin erythema increased, which gradually fused into pieces on his neck, chest and limbs. And his heart rate increased to 160 beats/min. Red man syndrome induced by vancomycin was considered. Vancomycin was stopped immediately and no antiallergic agents were given. About one hour later, the skin rash disappeared gradually and the heart rate decreased to 140 beats/min. The next day, the skin color returned to normal. Then teicoplanin combined with imipenem and cilastatin sodium were given according to the results of drug sensitivity test in sputum culture. The rash did not recur. Two weeks later, his pneumonia improved and he was discharged.