Objective To explore the advantages and disadvantages of da Vinci robotic-assisted thoracoscopic resection of pediatric posterior mediastinal tumors compared to traditional thoracoscopic surgery.Methods A total of 79 pediatric patients who underwent posterior mediastinal tumor resection at Union Hospital,Tongji Medical College,Huazhong University of Sci-ence and Technology,between January 2018 and October 2021 were included.Among them,47 patients underwent da Vinci ro-botic-assisted thoracoscopic surgery(Group A),and 32 patients underwent traditional thoracoscopic surgery(Group B).The pa-tients'age,gender,weight,tumor type,size,surgical time,intraoperative and postoperative complications,and other factors were compared and analyzed.Results There were 44 male and 35 female patients,with an average age of 4.5 years[(4.7±2.4)vs.(4.4±1.8),P=0.19]and an average weight of 21.7 kg[(23.6±7.5)vs.(20.9±6.1),P=0.10].Tumor sizes were(5.2±3.1)cm vs.(4.5±2.3)cm(P=0.07).All surgeries were completed safely with no intraoperative deaths.Pathological re-sults showed 25 cases of ganglioneuroma,19 cases of ganglioneuroblastoma,16 cases of neuroblastoma,10 cases of lymphangio-ma,8 cases of foregut cyst,and 1 case of lipoblastoma.One patient required conversion to thoracotomy due to intraoperative bleeding.The average anesthesia time[(127±25)vs.(124±30)min,P=0.42]and the operative time[(84±17)vs.(102±27)min,P=0.02)were significantly different.Estimated intraoperative blood loss[(14.6±4.4)vs.(15.4±5.3)mL,P=0.38]and the chest drainage time[(3.7±2.5)vs.(4.1±3.0)days,P=0.09]varied between groups.The average lengths of hospital stay were different[(7.2±1.9)vs.(7.4±2.3)days,P=0.40].Postoperative complications included 1 case of chylo-thorax,3 cases of pneumothorax,and 1 case of Horner's syndrome in Group A.There were 1 case of hemothorax,4 cases of pneumothorax,and 1 case of Horner's syndrome in Group B.Patients with ganglioneuroblastoma and neuroblastoma received postoperative chemotherapy.Follow-up for 2 to 5 years showed that all children recovered well,with no recurrence.Conclusion Both da Vinci robotic-assisted surgery and traditional thoracoscopic surgery are safe and feasible for pediatric mediastinal tumor surgery.The optimized instruments of the da Vinci robotic surgical system offer advantages in surgeries involving larger tumors or complex anatomical structures.

With the rapid development of generative artificial intelligence(GAI)technologies,their widespread application in academic research and writing is continuously expanding the boundaries of sci-entific inquiry.However,this trend has also raised a series of ethical and regulatory challenges,inclu-ding issues related to authorship,content authenticity,citation accuracy,and accountability.In light of the growing involvement of AI in generating academic content,establishing an open,controllable,and trustworthy ethical governance framework has become a key task for safeguarding research integrity and maintaining trust within the academic community.This expert consensus outlines ethical requirements across key stages of AI-assisted academic writing-including topic selection,data management,citation practices,and authorship attribution.It aims to clarify the boundaries and ethical obligations surrounding AI use in academic writing,ensuring that technological tools enhance efficiency without compromising in-tegrity.The goal is to provide guidance and institutional support for building a responsible and sustainable research ecosystem.

With the rapid development of generative artificial intelligence(GAI)technologies,their widespread application in academic research and writing is continuously expanding the boundaries of sci-entific inquiry.However,this trend has also raised a series of ethical and regulatory challenges,inclu-ding issues related to authorship,content authenticity,citation accuracy,and accountability.In light of the growing involvement of AI in generating academic content,establishing an open,controllable,and trustworthy ethical governance framework has become a key task for safeguarding research integrity and maintaining trust within the academic community.This expert consensus outlines ethical requirements across key stages of AI-assisted academic writing-including topic selection,data management,citation practices,and authorship attribution.It aims to clarify the boundaries and ethical obligations surrounding AI use in academic writing,ensuring that technological tools enhance efficiency without compromising in-tegrity.The goal is to provide guidance and institutional support for building a responsible and sustainable research ecosystem.

Objective To analyze the risk factors for increased drainage volume after open transforaminal lumbar interbody fusion(TLIF),and to establish a predictive model and then validate it.Methods The clinical data of 680 patients who underwent open TLIF at the General Hospital of Northern Theater Command from January 2016 to December 2019 were collected and the patients were randomly divided into the training group(n=476)and the validation group(n=204).Taking the predictive factors screened out by LASSO regression analysis as independent variables,a multivariate Logistic regression predictive model was constructed.The model was internally validated through the receiver operating characteristic(ROC)curve,Hosmer-Lemeshow goodness-of-fit test,and calibration curve,and its clinical utility was assessed via decision curve analysis(DCA).Results LASSO regression analysis screened out four predictive variables:age,number of surgical segments,operative duration,and intraoperative blood loss.The multivariate Logistic regression predictive model demonstrated that age≥60 years,number of surgical segments≥4,operative duration≥2 hours,and intraoperative blood loss≥200 mL were independent influencing factors for the increased postoperative drainage volume in patients undergoing TLIF(P<0.05).ROC curve analysis revealed an area under the curve(AUC)of 0.816(95%CI:0.798 to 0.867)in the training group and 0.783(95%CI:0.685 to 0.823)in the validation group,indicating that the predictive model had good discriminatory ability.Additionally,the Hosmer-Lemeshow goodness-of-fit test and calibration curve indicated that the predictive model had a good degree of fit,and the predicted probability was basically consistent with the actual probability,demonstrating a good calibration.The DCA results confirmed that this predictive model could be applied in clinical practice.Conclusion The risk factors for increased drainage volume after open TLIF include age,number of surgical segments,operative duration,and intraoperative blood loss.The predictive model established based on these factors demonstrates good performance,and it can be applied in clinical guidance for the selection of drainage tube removal time after TLIF.

Objective To explore the advantages and disadvantages of da Vinci robotic-assisted thoracoscopic resection of pediatric posterior mediastinal tumors compared to traditional thoracoscopic surgery.Methods A total of 79 pediatric patients who underwent posterior mediastinal tumor resection at Union Hospital,Tongji Medical College,Huazhong University of Sci-ence and Technology,between January 2018 and October 2021 were included.Among them,47 patients underwent da Vinci ro-botic-assisted thoracoscopic surgery(Group A),and 32 patients underwent traditional thoracoscopic surgery(Group B).The pa-tients'age,gender,weight,tumor type,size,surgical time,intraoperative and postoperative complications,and other factors were compared and analyzed.Results There were 44 male and 35 female patients,with an average age of 4.5 years[(4.7±2.4)vs.(4.4±1.8),P=0.19]and an average weight of 21.7 kg[(23.6±7.5)vs.(20.9±6.1),P=0.10].Tumor sizes were(5.2±3.1)cm vs.(4.5±2.3)cm(P=0.07).All surgeries were completed safely with no intraoperative deaths.Pathological re-sults showed 25 cases of ganglioneuroma,19 cases of ganglioneuroblastoma,16 cases of neuroblastoma,10 cases of lymphangio-ma,8 cases of foregut cyst,and 1 case of lipoblastoma.One patient required conversion to thoracotomy due to intraoperative bleeding.The average anesthesia time[(127±25)vs.(124±30)min,P=0.42]and the operative time[(84±17)vs.(102±27)min,P=0.02)were significantly different.Estimated intraoperative blood loss[(14.6±4.4)vs.(15.4±5.3)mL,P=0.38]and the chest drainage time[(3.7±2.5)vs.(4.1±3.0)days,P=0.09]varied between groups.The average lengths of hospital stay were different[(7.2±1.9)vs.(7.4±2.3)days,P=0.40].Postoperative complications included 1 case of chylo-thorax,3 cases of pneumothorax,and 1 case of Horner's syndrome in Group A.There were 1 case of hemothorax,4 cases of pneumothorax,and 1 case of Horner's syndrome in Group B.Patients with ganglioneuroblastoma and neuroblastoma received postoperative chemotherapy.Follow-up for 2 to 5 years showed that all children recovered well,with no recurrence.Conclusion Both da Vinci robotic-assisted surgery and traditional thoracoscopic surgery are safe and feasible for pediatric mediastinal tumor surgery.The optimized instruments of the da Vinci robotic surgical system offer advantages in surgeries involving larger tumors or complex anatomical structures.

Objective To analyze the risk factors for increased drainage volume after open transforaminal lumbar interbody fusion(TLIF),and to establish a predictive model and then validate it.Methods The clinical data of 680 patients who underwent open TLIF at the General Hospital of Northern Theater Command from January 2016 to December 2019 were collected and the patients were randomly divided into the training group(n=476)and the validation group(n=204).Taking the predictive factors screened out by LASSO regression analysis as independent variables,a multivariate Logistic regression predictive model was constructed.The model was internally validated through the receiver operating characteristic(ROC)curve,Hosmer-Lemeshow goodness-of-fit test,and calibration curve,and its clinical utility was assessed via decision curve analysis(DCA).Results LASSO regression analysis screened out four predictive variables:age,number of surgical segments,operative duration,and intraoperative blood loss.The multivariate Logistic regression predictive model demonstrated that age≥60 years,number of surgical segments≥4,operative duration≥2 hours,and intraoperative blood loss≥200 mL were independent influencing factors for the increased postoperative drainage volume in patients undergoing TLIF(P<0.05).ROC curve analysis revealed an area under the curve(AUC)of 0.816(95%CI:0.798 to 0.867)in the training group and 0.783(95%CI:0.685 to 0.823)in the validation group,indicating that the predictive model had good discriminatory ability.Additionally,the Hosmer-Lemeshow goodness-of-fit test and calibration curve indicated that the predictive model had a good degree of fit,and the predicted probability was basically consistent with the actual probability,demonstrating a good calibration.The DCA results confirmed that this predictive model could be applied in clinical practice.Conclusion The risk factors for increased drainage volume after open TLIF include age,number of surgical segments,operative duration,and intraoperative blood loss.The predictive model established based on these factors demonstrates good performance,and it can be applied in clinical guidance for the selection of drainage tube removal time after TLIF.

The working principle and development of flexible semiconductor devices based on organic field effect transistor(OFET)technology were introduced.The current research status of OFET-based wearable flexible monitoring devices were reviewed,including biomechanical monitoring devices,tattoo biomonitoring devices and cellular detection devices and etc.The deficiencies of OFET-based wearable flexible monitoring devices were analyzed,and it's pointed out that miniaturization,personalization and diversification were the directions for the development of the future OFET-based wearable flexible moni-toring devices.[Chinese Medical Equipment Journal,2024,45(1):93-100]

Objective To assess the clinical short-term outcomes of implanting D-shant atrial shunt device(aSD)in a single center for patients with heart failure with reduced ejection fraction(HFrEF).Methods From January 2022 to January 2023,a retrospective analysis was conducted on 12 patients with HFrEF who underwent percutaneous implantation of a D-shant aSD.We assessed cardiac chamber size and ventricular function using echocardiography,right heart catheterization measurements and patient clinical indicators were collected,follow up data of 12 months postoperative and pre-implantation D-shant were compared.The primary endpoint of the study was the cumulative occurrence of adverse cardiac,neurologic,or renal events during the follow-up period.Secondary endpoints were improvements in functional status included cardiac function,quality of life,and exercise capacity.Results All 12 patients underwent successful percutaneous inter-atrial shunting procedures using the D-shant.Postoperative immediately fluoroscopy and echocardiography confirmed accurate localization and patency of the atrial shunt devices in all cases.Postoperative hemodynamic assessment revealed a significant decrease in pulmonary capillary wedge pressure[(29.8±3.4)mmHg vs.(17.8±0.8)mmHg,P＜0.001].During 12 months follow-up,the cumulative adverse event rate was 8.3％(one patient received a heart transplant),a significant reduction in left atrial diameter from(65.8±6.5)mm to(48.0±4.5)mm(P＜0.001)was observed.Furthermore,there was notable improvement in clinical cardiac function indices quality of life,and exercise capacity of the patients.Conclusions This single-center retrospective study found that the use of a D-shant aSD to perform percutaneous interatrial shunting in patients with HFrEF is safe and effective.Short-term follow-up demonstrated sustained patency of the shunt and that the intervention was associated with improved functional status.

Objective:To investigate the molecular mechanism and distribution characteristics of RhD negative phenotypes in Han population of blood donors in Wuhu city.Methods:A total of 210 RhD-samples from August 2021 to August 2022 were screened by serological test and collected from Wuhu Central Blood Station for the voluntary blood donor population.Exons 1 and 10 of the RHD gene were amplificated by PCR to determine whether the samples had the RHD gene.Exons 1-10 of the RHD gene were amplificated by PCR and zygosity analysis were performed in 82 samples containing D gene,and Sanger sequencing was performed on 55 samples containing all RHD exons to determine the genotype.Results:Among 210 RhD-specimens,128 cases(60.38％)had RHD gene deletion.27 cases had partial exons of RHD,including 2 cases with RHD*DVI.3/RHD*01N.01,24 cases with RHD*01N.04/RHD*01N.01,and 1 case with RHD-CE(2-10)/RHD*01N.01.55 cases had retained all of 10 exons,including 4 cases with RHD*01/RHD*01N.01,6 cases with RHD*15/RHD*01N.01,1 case with RHD*01W.72/RHD*01N.01,1 case with RHD*15/RHD*01EL.01,39 cases with RHD*01EL.01/RHD*01N.01,and the remaining 4 cases were determined to have no RHD gene deletion by zygosity analysis and sequencing showed the presence of 1227G＞A mutation loci.Conclusion:There is polymorphism in the molecular mechanism of RhD-D gene in Wuhu blood donor population,among which RHD*01EL.01 and RHD*15 are the main variants in this region.The results of this study provide a theoretical basis for RhD blood group identification and clinical blood transfusion in this region.

Renal fibrosis is a common pathological manifestation of all chronic kidney diseases.Ferroptosis is closely related to the pathogenesis of renal fibrosis and can influence the onset of renal fibrosis,and it is the most critical step in the development of renal fibrosis.The paper describes the relationship between ferroptosis and renal fibrosis,discusses the research progress of ferroptosis on renal fibrosis,and further summarizes,analyzes,and describes the effective and highly targeted natural active ingredients of traditional Chinese medicines against ferroptosis,and concludes that the reversal of renal fibrosis is achieved through the regulation of the key targets of ferroptosis,with a view to providing a broad new direction for its prospects in the field of renal fibrotic disease prevention and treatment;and to provide a scientific guide for clinical treatment and basis for clinical treatment.