Hearing loss is the most prevalent disabling disease. Cochlear implantation（CI） serves as the primary intervention for severe to profound hearing loss. This consensus systematically explores the value of genetic diagnosis in the pre-operative assessment and efficacy prognosis for CI. Drawing upon domestic and international research and clinical experience, it proposes an evidence-based medicine three-tiered prognostic classification system（Favorable, Marginal, Poor）. The consensus focuses on common hereditary non-syndromic hearing loss（such as that caused by mutations in genes like GJB2, SLC26A4, OTOF, LOXHD1） and syndromic hereditary hearing loss（such as Jervell & Lange-Nielsen syndrome and Waardenburg syndrome）, which are closely associated with congenital hearing loss, analyzing the impact of their pathological mechanisms on CI outcomes. The consensus provides recommendations based on multiple round of expert discussion and voting. It emphasizes that genetic diagnosis can optimize patient selection, predict prognosis, guide post-operative rehabilitation, offer stratified management strategies for patients with different genotypes, and advance the application of precision medicine in the field of CI.
Humans ; Cochlear Implantation ; Prognosis ; Hearing Loss/surgery* ; Consensus ; Connexin 26 ; Mutation ; Sulfate Transporters ; Connexins/genetics*

OBJECTIVES: This study aims to analyze the biomechanics of three kinds of rigid internal fixation methods for condylar head fractures. METHODS: A three dimensional finite element model of the normal mandible was constructed. It was then used to prepare condylar head fracture finite element model and three kinds of rigid internal fixation finite element model (unilateral tension screw, bilateral tension screw, tension screw+titanium plate). The mechanical characteristics and changes of the mandible condyle under the same mechanical conditions were compared among the three different rigid internal fixation methods. RESULTS: The maximum equivalent stress and displacement of the non-free end of condyle under the rigid internal fixation method of unilateral tension screw were 71.03 MPa and 4.72 mm, respectively. The maximum equivalent stress and displacement of the free end of condyle were 78.45 MPa and 4.50 mm, respectively. The maximum stress of fracture suture was 3.27 MPa. The maximum equivalent stress and displacement of the non-free end of condyle under the rigid internal fixation method of bilateral tension screw were 70.52 MPa and 4.00 mm, respectively. The maximum equivalent stress and displacement of the free end of condyle were 72.49 MPa and 3.85 mm, respectively. The maximum stress of fracture suture was 2.33 MPa. The maximum equivalent stress and maximum displacement of the non-free end of condyle under the rigid internal fixation method of tension screw+titanium plate were 67.26 MPa and 2.66 mm, respectively. The maximum equivalent stress and maximum displacement of the free end of condyle were 69.66 MPa and 2.50 mm, respectively. The maximum stress of fracture suture was 2.18 MPa. CONCLUSIONS The tension screw+titanium plate rigid internal fixation method is the most conducive to biomechanical distribution for condylar head fractures.
Fracture Fixation, Internal/instrumentation* ; Mandibular Condyle/surgery* ; Biomechanical Phenomena ; Bone Screws ; Finite Element Analysis ; Humans ; Mandibular Fractures/surgery* ; Bone Plates ; Titanium ; Stress, Mechanical

Rosacea is a common chronic inflammatory skin disease whose exact pathogenesis has not been fully elucidated. Metabolomics has been widely used in the field of life science to provide strong evidence for exploring the pathogenesis and biomarkers of diseases. In recent years, researchers have applied metabolomics to rosacea-related fields using sebum, tear, saliva, and serum samples. This review summarizes research progress on current metabolomics methods and the application of metabolomics in rosacea.

Objective: To analyze the incidence of adenoid hypertrophy and risk factors for secretory otitis media among primary and middle school students aged 7-16 years in Suzhou,and to provide a reference for its clinical disagnosis,treatment and prognosis. Methods: The primary and secondary school students aged from 7 to 16 in Suzhou from January 2015 to December 2019 were selected by using cluster stratified sampling, adenoid hypertrophy cases were screened and diagnosed by MR, the epidemiology of adenoid hypertrophy and related risk factors of complicated secretory otitis media were analyzed among participants. Results: Among 327 cases of adenoid hypertrophy were screened, with a prevalence rate of 10.95%. From 2015 to 2019, the prevalence rate of adenoid hypertrophy among primary and middle school students increased by year. The prevalence rate in 2019 was 10.95% higher than 9.20% in 2015 and 9.95% in 2016. The prevalence rate of adenoid hypertrophy in boys was 12.29%, which was higher than 9.48% in girls( χ 2=6.04, P <0.05). The prevalence rate of adenoid hypertrophy between 7-10 years old was 15.08% and higher than 6.36 %( χ 2=57.93, P <0.05) for primary and middle school students aged 11-16. Among the 327 primary and middle school students with adenoid hypertrophy,a total of 20 had secretory otitis media, and the combined rate was 6.12%. The age of the combined secretory otitis media group was younger than that of the non combined group, the severity of adenoid hypertrophy was higher than that of the non combined group, and serum IL-4, TNF-α, IgA, IgG, and IgM were higher than those of the non combined group ( P <0.05). Adenoid hypertrophy complicated with secretory otitis media was associated with age, severity, IL-4, IgG, and IgM ( P <0.05). Conclusion The prevalence of adenoid hypertrophy among primary and secondary school students aged 7-16 years in Suzhou is relatively high, which is related to gender, age, time of onset and season. Secretory otitis media in adenoids hypertrophy children and adolescents should attract sufficient attention from the whole society.

Objective: To explore the therapeutic feasibility of uterus transplantation for uterine infertility. Methods: Retrospective analysis was performed for the diagnosis, treatment and pregnancy course of the first domestic case of uterus transplantation and the relevant literature reviewed. The recipient was a 22-year-old woman with a congenital absence of uterus and vagina. Previously she underwent vaginal reconstruction and the donor was her mother. The specific procedures included donor/recipient screening, ethical argumentation, assisted reproductive technology of obtaining frozen embryos, Vinci robot-assisted uterine procurement, orthotopic replacement & fixation of retrieved uterus, revascularization; immunoregulation & monitoring of transplanted uterine recipient, assisted reproductive technology after transplantation and gestational management. Results: The durations of donor and recipient surgeries were 360 and 530 min respectively. No complications of recipient or donor occurred during the perioperative period. First menstruation occurred at 40 days post-transplantation and regularly thereafter. Pregnancy occurred after embryo transfer at 31 months post-transplantation. No rejection episodes occurred after transplantation or during gestation. Caesarean delivery occurred near gestational week 34. The boy weighed 2000 grams at birth and the mother remained well. Conclusions In conjunctions with literature review, uterine infertility may be treated by modified uterus transplantation. And a new path is paved for healthy pregnancy of women with uterine infertility.

Objective To explore the distribution of pathogens, bacterial drug resistance, clinical features and prognosis of bacterial meningitis (BM) in children.MethodsThe clinical data of children diagnosed with BM during January 2011 to July 2015 were retrospectively analyzed. Children were divided into good outcome group and poor outcome group by the outcome at discharge. The distribution of pathogens, bacterial drug resistance, clinical features, and prognosis were analyzed among different groups.ResultsThere were included 95 children diagnosed with BM,. among whom 69 (72.6%) children had Gram-positive bacterial infections with predominantStreptococcus pneumonia (43 cases, 45.3%) and 26 (27.4%) children had Gram-negative bacterial infections with predominantEscherichia coli (13 cases, 13.7%). More than 50%Streptococcus pneumonia andEscherichia coli were resisted to penicillin. The neurological complications in children with BM included subdural effusions, hydrocephalus, cerebral parenchyma injury, and hearing and visual impairment, et.al. Multivariate logistic regression analysis showed that consciousness, coma, and low level of glucose in cerebrospinal lfuid were the independent risk factors for adverse outcome at discharge.ConclusionStreptococcus pneumonia andEscherichia coli were the predominant pathogens in children with BM with high resistance rate to penicillin. BM children may have varying degrees of neurological sequelae. The unconsciousness and low level of glucose in cerebrospinal lfuid were associated with unfavorable outcomes at discharge.

OBJECTIVE: To investigate the improvement of severe-to-profound hearing-impaired adults received REZ-I cochlear implant and to give an analysis to some Chinese dialect speakers. METHOD: With standard assessment table and standard testing program, 48 post-lingual hearing-impaired adults were divided into Mandarin language group (41 cases) and dialect group (7 cases). All of them were tested and scored for their hearing and speech perception abilities after 90 days rehabilitation. Sound field audio-metrics were performed at the same time. Clinical effectiveness of each subject in the two groups were assessed according to criteria, and efficacy index were statistically analyzed. RESULT: The total effective rates were 100% in both groups after 90 days hearing and speech perception rehabilitation. The clinical effectiveness were equal and there was no statistic significant differences between the groups. CONCLUSION REZ-I cochlear implantation has similar effect for Chinese dialect spoken adults compared to mandarin spoken adults with post-lingual severe-to-profound hearing loss via appropriate postoperative rehabilitation.
Adolescent ; Adult ; Asian Continental Ancestry Group ; Cochlear Implants ; Deafness ; therapy ; Female ; Humans ; Language ; Male ; Middle Aged ; Speech Perception ; Treatment Outcome ; Young Adult