Objective To explore the feasibility and safety of using indocyanine green combined with autologous blood and methylene blue for localization of small lung nodules during thoracoscopic wedge resection. Methods Patients who underwent CT-guided percutaneous lung puncture injection of localization agents to locate lung nodules at the First Affiliated Hospital of Fujian Medical University from November 2023 to January 2024 were selected. Under thoracoscopy, lung nodules were located by white light mode, fluorescence mode, or near-infrared mode and wedge resection was performed. The feasibility of using indocyanine green combined with autologous blood and methylene blue for localization of small lung nodules was preliminarily verified by evaluating whether the localization agent concentrated around the nodules, and the safety of this method was verified by analyzing the incidence of adverse reactions during patient puncture and surgery. Results A total of 30 patients with lung nodules were included, including 10 males and 20 females, with an average age of (55.5±11.2) years. In 26 patients, the amount of localization agent used was moderate, the localization agent concentrated around the nodules, and successful precise localization of small lung nodules was achieved. In 4 patients, due to excessive use of localization agent, the marker was diffuse with pleural staining. The overall localization success rate was 86.7%, and when the injection volume of localization agent was 0.2-0.5 mL, the localization success rate was 100.0%. All patients successfully completed thoracoscopic wedge resection and found nodule lesions, with negative margins and a distance from the margin to the lesion that met the requirements. There were no complications. Conclusion Thoracoscopic surgery using indocyanine green combined with autologous blood and methylene blue for localization of small lung nodules is safe and feasible.

Objective To investigate the prognosis and satisfaction of the R2 intervention procedure and develop related predictive models. Methods The clinical data of 64 patients with primary craniofacial hyperhidrosis who underwent R2 intervention surgery at the First Affiliated Hospital of Fujian Medical University from November 2018 to October 2022 were retrospectively analyzed. By statistically analyzing the risk factors for compensatory hyperhidrosis (CH) and satisfaction, and conducting feature screening, a relevant prediction model was established. Results Finally, 51 patients were collected, including 43 (84.3%) males and 8 (15.7%) females, with an average age of (30.27±7.22) years. Overall postoperative satisfaction was high, with only 5.9% of patients expressing regret about the surgery. However, 92.2% of patients experienced CH. The onset of postoperative CH was most prominent within the first 3 months postoperatively, with the incidence rate stabilizing thereafter. Preoperative heart rate and R2 sympathetic nerve clipping were identified as independent risk factors for severe CH. The preoperative body mass index, the degree of sweating in the chest and abdomen, are significantly correlated with postoperative satisfaction. Conclusion The R2 intervention surgery effectively alleviates the symptoms of primary craniofacial hyperhidrosis, and patient satisfaction is high.

This study aimed to characterize and identify the non-volatile components in aqueous and ethanolic extracts of the stems and leaves of Rhododendron tomentosum by using sensitive and efficient ultra-performance liquid chromatography-quadrupole-time of flight mass spectrometry(UHPLC-Q-TOF-MS) combined with a self-built information database. By comparing with reference compounds, analyzing fragment ion information, searching relevant literature, and using a self-built information database, 118 compounds were identified from the aqueous and ethanolic extracts of R. tomentosum, including 35 flavonoid glycosides, 15 phenolic glycosides, 12 flavonoids, 7 phenolic acids, 7 phenylethanol glycosides, 6 tannins, 6 phospholipids, 5 coumarins, 5 monoterpene glycosides, 6 triterpenes, 3 fatty acids, and 11 other types of compounds. Among them, 102 compounds were reported in R. tomentosum for the first time, and 36 compounds were identified by comparing them with reference compounds. The chemical components in the ethanolic and aqueous extracts of R. tomentosum leaves and stems showed slight differences, with 84 common chemical components accounting for 71.2% of the total 118 compounds. This study systematically characterized and identified the non-volatile chemical components in the ethanolic and aqueous extracts of R. tomentosum for the first time. The findings provide a reference for active ingredient research, quality control, and product development of R. tomentosum.
Rhododendron/chemistry* ; Chromatography, High Pressure Liquid/methods* ; Drugs, Chinese Herbal/chemistry* ; Mass Spectrometry/methods* ; Plant Leaves/chemistry*

Objective A typical case survey and elemental analysis of the implementation of Antimicrobial Steward-ship(AMS)in a medical institution in Shanghai,summarize the excellent experience of AMS in practice,and pro-vide a reference for the further promotion and implementation of AMS in the future.Methods Through purposive sam-pling,7 typical hospitals in Shanghai were selected as sampling hospitals,and key informed persons of AMS were invited to conduct semi-structured interviews.Based on the core elements of AMS theory,it conducted subject analysis to summarize the implementation and excellent practical experience of AMS in hospitals.Results The sample hospitals are excellent in the AMS elements of leadership and accountability,but need to be further strengthened in training,tracking and reporting.On the basis of routine bundle of interventions,some hospitals actively explored and expanded AMS actions according to their own disciplinary advantages.Combined with a series of internal and ex-ternal control measures,AMS strategy with the characteristics of hospitals has been formed,and the related indica-tors of antibiotics in hospitals have been improved.Conclusion In the follow-up process of AMS,hospitals can draw on excellent experience,carry out the appropriate AMS strategy on the basis of consolidating their own governance structure and routine interventions.Besides,relevant departments should increase investment in AMS information systems and human resources in hospitals to ensure the implementation of AMS.

Animals ; Macaca mulatta ; Optic Disk ; Glaucoma ; Craniocerebral Trauma ; Intraocular Pressure ; Low Tension Glaucoma

Occupational exposure to ionizing radiation represents a critical factor contributing to health risks in workplaces. Previous experimental and clinical studies have demonstrated that ionizing radiation affects human health. Therefore, scientific assessment of health risk caused by ionizing radiation and effective protection against ionizing radiation are of great importance to formulate the preventive interventions against occupational exposure to ionizing radiation. This review summarizes the advances in the research on health effects, health risk assessment methods, and protective interventions of ionizing radiation. We call for research on the health effects of low-dose radiation, individual difference, and optimization of preventive strategies. In addition, improved mechanisms of health monitoring, periodical healthy examinations, and monitoring of radiation doses should be implemented. Moreover, strict compliance to operating procedures and occupational preventive interventions are recommended. These measures aim to minimize the potential harmlessness of occupational exposure to ionizing radiation, thereby safeguarding the health and safety of individuals exposed to ionizing radiation.

Compensatory hyperhidrosis (CH) is a severe side effect that occurs after endoscopic thoracic sympathotomy (ETS) for the treatment of palmar hyperhidrosis. CH significantly interferes with daily activities such as work, study, and social interactions, leading to a substantial decrease in the quality of life for patients. Preventing and treating CH are currently important and challenging issues in minimally invasive surgery for palmar hyperhidrosis. In this report, we presented a 29-year-old male patient who experienced severe CH for 8 years following ETS. The patient underwent staged unilateral endoscopic expanded sympathotomy (ES) at our hospital on December 11, 2023 and January 3, 2024, targeting the R4-R10 levels. After a 3-month follow-up, the patient experienced significant improvement in clinical symptoms and quality of life, with no recurrence of palmar hyperhidrosis or other complications. The treatment outcome was satisfactory.

Objective A typical case survey and elemental analysis of the implementation of Antimicrobial Steward-ship(AMS)in a medical institution in Shanghai,summarize the excellent experience of AMS in practice,and pro-vide a reference for the further promotion and implementation of AMS in the future.Methods Through purposive sam-pling,7 typical hospitals in Shanghai were selected as sampling hospitals,and key informed persons of AMS were invited to conduct semi-structured interviews.Based on the core elements of AMS theory,it conducted subject analysis to summarize the implementation and excellent practical experience of AMS in hospitals.Results The sample hospitals are excellent in the AMS elements of leadership and accountability,but need to be further strengthened in training,tracking and reporting.On the basis of routine bundle of interventions,some hospitals actively explored and expanded AMS actions according to their own disciplinary advantages.Combined with a series of internal and ex-ternal control measures,AMS strategy with the characteristics of hospitals has been formed,and the related indica-tors of antibiotics in hospitals have been improved.Conclusion In the follow-up process of AMS,hospitals can draw on excellent experience,carry out the appropriate AMS strategy on the basis of consolidating their own governance structure and routine interventions.Besides,relevant departments should increase investment in AMS information systems and human resources in hospitals to ensure the implementation of AMS.

Objective A typical case survey and elemental analysis of the implementation of Antimicrobial Steward-ship(AMS)in a medical institution in Shanghai,summarize the excellent experience of AMS in practice,and pro-vide a reference for the further promotion and implementation of AMS in the future.Methods Through purposive sam-pling,7 typical hospitals in Shanghai were selected as sampling hospitals,and key informed persons of AMS were invited to conduct semi-structured interviews.Based on the core elements of AMS theory,it conducted subject analysis to summarize the implementation and excellent practical experience of AMS in hospitals.Results The sample hospitals are excellent in the AMS elements of leadership and accountability,but need to be further strengthened in training,tracking and reporting.On the basis of routine bundle of interventions,some hospitals actively explored and expanded AMS actions according to their own disciplinary advantages.Combined with a series of internal and ex-ternal control measures,AMS strategy with the characteristics of hospitals has been formed,and the related indica-tors of antibiotics in hospitals have been improved.Conclusion In the follow-up process of AMS,hospitals can draw on excellent experience,carry out the appropriate AMS strategy on the basis of consolidating their own governance structure and routine interventions.Besides,relevant departments should increase investment in AMS information systems and human resources in hospitals to ensure the implementation of AMS.

Objective A typical case survey and elemental analysis of the implementation of Antimicrobial Steward-ship(AMS)in a medical institution in Shanghai,summarize the excellent experience of AMS in practice,and pro-vide a reference for the further promotion and implementation of AMS in the future.Methods Through purposive sam-pling,7 typical hospitals in Shanghai were selected as sampling hospitals,and key informed persons of AMS were invited to conduct semi-structured interviews.Based on the core elements of AMS theory,it conducted subject analysis to summarize the implementation and excellent practical experience of AMS in hospitals.Results The sample hospitals are excellent in the AMS elements of leadership and accountability,but need to be further strengthened in training,tracking and reporting.On the basis of routine bundle of interventions,some hospitals actively explored and expanded AMS actions according to their own disciplinary advantages.Combined with a series of internal and ex-ternal control measures,AMS strategy with the characteristics of hospitals has been formed,and the related indica-tors of antibiotics in hospitals have been improved.Conclusion In the follow-up process of AMS,hospitals can draw on excellent experience,carry out the appropriate AMS strategy on the basis of consolidating their own governance structure and routine interventions.Besides,relevant departments should increase investment in AMS information systems and human resources in hospitals to ensure the implementation of AMS.